Functions, mechanisms and regulation of Pumilio/Puf family RNA binding proteins: a comprehensive review

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

(2019) Davide D’Amico et al.   MOLECULAR CELL

RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

(2019) Michael W Webster et al.   eLife

Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b

(2019) Kaibo Lin et al.   Cell Reports

Functional and molecular characterization of the conserved Arabidopsis PUMILIO protein, APUM9

(2019) Tünde Nyikó et al.   PLANT MOLECULAR BIOLOGY

Myocyte enhancer factor-2 and p300 interact to regulate the expression of homeostatic regulator Pumilio in Drosophila

(2019) Wei-Hsiang Lin et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The target specificity of the RNA binding protein Pumilio is determined by distinct co-factors

(2019) Sumira Malik et al.   BIOSCIENCE REPORTS

Identification of Arabidopsis CCR4-NOT complexes with Pumilio RNA binding proteins, APUM5 and APUM2

(2019) Toshihiro Arae et al.   PLANT AND CELL PHYSIOLOGY

PUMILIO hyperactivity drives premature aging of Norad-deficient mice

(2019) Florian Kopp et al.   eLife

PUM1 promotes ovarian cancer proliferation, migration and invasion

(2018) Xue Guan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Salt hypersensitive mutant 9, a nucleolar APUM23 protein, is essential for salt sensitivity in association with the ABA signaling pathway in Arabidopsis

(2018) Kai-Chau Huang et al.   BMC PLANT BIOLOGY

A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures

(2018) Vincenzo A. Gennarino et al.   CELL

Novel insights into global translational regulation through Pumilio family RNA-binding protein Puf3p revealed by ribosomal profiling

(2018) Zhe Wang et al.   CURRENT GENETICS

SAM68 is required for regulation of Pumilio by the NORAD long noncoding RNA

(2018) Ailone Tichon et al.   GENES & DEVELOPMENT

Puf3 participates in ribosomal biogenesis in malaria parasites

(2018) Xiaoying Liang et al.   JOURNAL OF CELL SCIENCE

An RNAi-mediated screen identifies novel targets for next-generation antiepileptic drugs based on increased expression of the homeostatic regulator pumilio

(2018) Wei-Hsiang Lin et al.   JOURNAL OF NEUROGENETICS

Pumilio directs deadenylation-associated translational repression of the cyclin-dependent kinase 1 activator RGC-32

(2018) Michèle Brocard et al.   NUCLEIC ACIDS RESEARCH

PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues

(2018) Marcin Sajek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Essential requirement of mammalian PUMILIO family in embryonic development

(2018) Kaibo Lin et al.   MOLECULAR BIOLOGY OF THE CELL

Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins

(2017) Meng Zhang et al.   GENES & DEVELOPMENT

Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins

(2017) Jennifer A Bohn et al.   NUCLEIC ACIDS RESEARCH

Reduced Expression ofAPUM24, Encoding a Novel rRNA Processing Factor, Induces Sugar-Dependent Nucleolar Stress and Altered Sugar Responses inArabidopsis thaliana

(2017) Shugo Maekawa et al.   PLANT CELL

An Arabidopsis divergent pumilio protein, APUM24, is essential for embryogenesis and required for faithful pre-rRNA processing

(2017) Thiruvenkadam Shanmugam et al.   PLANT JOURNAL

PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2

(2017) Yonghong Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudouridine and N 6 -methyladenosine modifications weaken PUF protein/RNA interactions

(2017) Pavanapuresan P. Vaidyanathan et al.   RNA

Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis

(2017) Manuel Hotz et al.   Nature Communications

Identification and characterization of roles for Puf1 and Puf2 proteins in the yeast response to high calcium

(2017) Ofir Haramati et al.   Scientific Reports

Alternative Polyadenylation in Triple-Negative Breast Tumors Allows NRAS and c-JUN to Bypass PUMILIO Posttranscriptional Regulation

(2016) Wayne O. Miles et al.   CANCER RESEARCH

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

(2016) Sungyul Lee et al.   CELL

CLAVATA-WUSCHEL signaling in the shoot meristem

(2016) Marc Somssich et al.   DEVELOPMENT

Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation

(2016) Arnaldo Carreira-Rosario et al.   DEVELOPMENTAL CELL

Seizure control through genetic and pharmacological manipulation of Pumilio inDrosophila: a key component of neuronal homeostasis

(2016) Wei-Hsiang Lin et al.   Disease Models & Mechanisms

Nop9 is a PUF-like protein that prevents premature cleavage to correctly process pre-18S rRNA

(2016) Jun Zhang et al.   Nature Communications

Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

(2016) Chase A Weidmann et al.   eLife

Pumilio1 Haploinsufficiency Leads to SCA1-like Neurodegeneration by Increasing Wild-Type Ataxin1 Levels

(2015) Vincenzo A. Gennarino et al.   CELL

A Nucleolar PUF RNA-binding Protein with Specificity for a Unique RNA Sequence

(2015) Chi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose-Regulated Phosphorylation of the PUF Protein Puf3 Regulates the Translational Fate of Its Bound mRNAs and Association with RNA Granules

(2015) Chien-Der Lee et al.   Cell Reports

Cytoplasmic Polyadenylation Element Binding Proteins in Development, Health, and Disease

(2014) Maria Ivshina et al.   Annual Review of Cell and Developmental Biology

APUM5, encoding a Pumilio RNA binding protein, negatively regulates abiotic stress responsive gene expression

(2014) Sung Huh et al.   BMC PLANT BIOLOGY

Characterization of TgPuf1, a member of the Puf family RNA-binding proteins from Toxoplasma gondii

(2014) Min Liu et al.   Parasites & Vectors

REDUCED DORMANCY5Encodes a Protein Phosphatase 2C That Is Required for Seed Dormancy inArabidopsis

(2014) Yong Xiang et al.   PLANT CELL

A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization

(2014) Chen Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation

(2014) Toshifumi Inada et al.   Frontiers in Genetics

Pumilio-2 Regulates Translation of Nav1.6 to Mediate Homeostasis of Membrane Excitability

(2013) H. E. Driscoll et al.   JOURNAL OF NEUROSCIENCE

The CCR4 Deadenylase Acts with Nanos and Pumilio in the Fine-Tuning of Mei-P26 Expression to Promote Germline Stem Cell Self-Renewal

(2013) Willy Joly et al.   Stem Cell Reports

Pumilio facilitates miRNA regulation of the E2F3 oncogene

(2012) W. O. Miles et al.   GENES & DEVELOPMENT

Identification of a Conserved Interface between PUF and CPEB Proteins

(2012) Zachary T. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arabidopsis Pumilio protein APUM5 suppresses Cucumber mosaic virus infection via direct binding of viral RNAs

(2012) S. U. Huh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for the Poly(A)-binding Protein Pab1p in PUF Protein-mediated Repression

(2011) Jacqueline J. Chritton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drosophila Pumilio Protein Contains Multiple Autonomous Repression Domains That Regulate mRNAs Independently of Nanos and Brain Tumor

(2011) C. A. Weidmann et al.   MOLECULAR AND CELLULAR BIOLOGY

Pumilio-2 Function in the Mouse Nervous System

(2011) Henrike Siemen et al.   PLoS One

PUMILIO-2 Is Involved in the Positive Regulation of Cellular Proliferation in Human Adipose-Derived Stem Cells

(2011) Patrícia Shigunov et al.   STEM CELLS AND DEVELOPMENT

Pumilio RNA Recognition: The Consequence of Promiscuity

(2011) Sean P. Ryder   STRUCTURE

Alternate Modes of Cognate RNA Recognition by Human PUMILIO Proteins

(2011) Gang Lu et al.   STRUCTURE

The Puf family of RNA-binding proteins in plants: phylogeny, structural modeling, activity and subcellular localization

(2010) Patrick PC Tam et al.   BMC PLANT BIOLOGY

The trypanosome Pumilio-domain protein PUF7 associates with a nuclear cyclophilin and is involved in ribosomal RNA maturation

(2010) Dorothea Droll et al.   FEBS LETTERS

Identification of novel markers for stem-cell niche of Arabidopsis shoot apex

(2010) Pooja Aggarwal et al.   GENE EXPRESSION PATTERNS

The Puf-family RNA-binding protein PfPuf2 regulates sexual development and sex differentiation in the malaria parasite Plasmodium falciparum

(2010) J. Miao et al.   JOURNAL OF CELL SCIENCE

A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

(2010) Martijn Kedde et al.   NATURE CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammalian Pumilio 2 regulates dendrite morphogenesis and synaptic function

(2010) J. P. Vessey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of Puf proteins in mRNA degradation and translation

(2010) Melanie A. Miller et al.   Wiley Interdisciplinary Reviews-RNA

Mef2-mediated transcription of the miR379–410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels

(2009) Roberto Fiore et al.   EMBO JOURNAL

Molecular characterization of Arabidopsis thaliana PUF proteins - binding specificity and target candidates

(2009) Carlos W. Francischini et al.   FEBS Journal

The Translational Repressors Nanos and Pumilio Have Divergent Effects on Presynaptic Terminal Growth and Postsynaptic Glutamate Receptor Subunit Composition

(2009) K. P. Menon et al.   JOURNAL OF NEUROSCIENCE

A 3′UTR Pumilio-Binding Element Directs Translational Activation in Olfactory Sensory Neurons

(2009) Julia A. Kaye et al.   NEURON

A Novel puf-A Gene Predicted from Evolutionary Analysis Is Involved in the Development of Eyes and Primordial Germ-Cells

(2009) Ming-Wei Kuo et al.   PLoS One

Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition

(2009) Q. Cao et al.   RNA

Trypanosoma brucei PUF9 Regulates mRNAs for Proteins Involved in Replicative Processes over the Cell Cycle

(2009) Stuart K. Archer et al.   PLoS Pathogens

RNA-binding proteins and post-transcriptional gene regulation

(2008) Tina Glisovic et al.   FEBS LETTERS

Pumilio Binds para mRNA and Requires Nanos and Brat to Regulate Sodium Current in Drosophila Motoneurons

(2008) N. I. Muraro et al.   JOURNAL OF NEUROSCIENCE

Multifunctional deadenylase complexes diversify mRNA control

(2008) Aaron C. Goldstrohm et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structures of Human Pumilio with Noncognate RNAs Reveal Molecular Mechanisms for Binding Promiscuity

(2008) Yogesh K. Gupta et al.   STRUCTURE

Identification of Synaptic Targets of Drosophila Pumilio

(2008) Gengxin Chen et al.   PLoS Computational Biology