Article
Food Science & Technology
Conor J. Gallagher, Ronald R. Bowsher, Amanda Clancy, Jeffrey S. Dover, Shannon Humphrey, Yan Liu, Gregg Prawdzik
Summary: This study evaluated the immunogenicity of DAXI in three phase 3 glabellar line studies and found low rates of antibody formation with no impact on DAXI efficacy.
Article
Surgery
Vince Bertucci, Jeremy B. Green, John P. Fezza, Jessica Brown, Conor J. Gallagher
Summary: Precise injection technique is crucial for achieving optimal eyebrow position and treatment efficacy when using DaxibotulinumtoxinA for Injection. The location, depth, and method of injection can impact the outcomes of eyebrow position. Precise injection targeting the specific muscle groups can result in better outcomes and longer duration of efficacy.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Surgery
Ankoor A. Talwar, Jared M. Shulkin, Michaela Hitchner, Phoebe B. McAuliffe, Abhishek A. Desai, Robyn B. Broach, Ivona Percec
Summary: This study aimed to identify predictors of facial injectable use after cosmetic facial surgery. The results showed an increased use of facial injectables, especially neurotoxins and facial fillers, among patients postoperatively.
AESTHETIC SURGERY JOURNAL
(2022)
Review
Food Science & Technology
Supriyo Choudhury, Mark R. Baker, Suparna Chatterjee, Hrishikesh Kumar
Summary: Botulinum toxin has evolved from a treatment for strabismus to the first-line treatment for focal dystonia, with at least six FDA-approved formulations available for diverse indications. These formulations have varying toxo-pharmacological properties and should not be used interchangeably. Synthetic and non-clostridial sources of BoNT are also nearing clinical use, and studies on mutations in natural toxins have led to modifications in the toxo-pharmacokinetic properties of BoNTs.
Article
Dermatology
Richard Glogau, Theda C. Kontis, Yan Liu, Conor J. Gallagher
Summary: Repeated treatment with DAXI showed progressive improvement in static glabellar lines, with an increase in the proportion of subjects without static glabellar lines observed after each treatment cycle.
DERMATOLOGIC SURGERY
(2021)
Article
Surgery
Nowell Solish, Michael A. C. Kane, Brian S. Biesman, Jessica Brown, Conor J. Gallagher
Summary: This study evaluates the impact of DAXI injection on eyebrow position and frontalis activity, showing that glabellar injection of DAXI can reduce frontalis activity and maintain or improve eyebrow position and shape.
AESTHETIC SURGERY JOURNAL
(2022)
Review
Food Science & Technology
Joely Kaufman-Janette, Sue Ellen Cox, Steven Dayan, John Joseph
Summary: High-dose BoNT-A treatments are feasible and may extend the duration of response without increasing safety concerns. By increasing the dosage, the formation of glabellar lines was inhibited, while maintaining patient satisfaction and a natural appearance.
Article
Dermatology
Sabrina G. Fabi, Joel L. Cohen, Lawrence J. Green, Sunil Dhawan, Theda C. Kontis, Leslie Baumann, Todd M. Gross, Conor J. Gallagher, Jessica Brown, Roman G. Rubio
Summary: The study demonstrates that DAXI shows highly consistent efficacy in repeat treatments, with a favorable safety profile and long duration of response.
DERMATOLOGIC SURGERY
(2021)
Article
Surgery
Maurizio Cavallini, Roberto Dell Avanzato, Salvatore Piero Fundaro, Fernando Urdiales-Galvez, Marco Papagni, Gloria Trocchi, Mauro Raichi, Michela Zazzaron
Summary: This study investigated the differences in distances between injection points of botulinum toxin in patients who persistently frown or rest. The results showed minimal differences between the two groups, especially in patients under 40 years old. Therefore, it is advisable for patients over 40 to persistently frown during injections.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Clinical Neurology
Jara Schulze, Christopher Sinke, Insa Neumann, M. Axel Wollmer, Tillmann H. C. Kruger
Summary: Meta-analyses indicate that glabellar botulinum toxin (BTX) injections can provide sustained relief from depressive symptoms. This is likely due to the disruption of facial feedback loops, which influence the experience of negative emotions. In this study, seed-based resting-state functional connectivity (rsFC) analysis was used to explore the effects of BTX and acupuncture on the motor system and emotion processing in individuals with borderline personality disorder (BPD). The results showed that BTX treatment led to abnormal rsFC in the anterior cingulate cortex (ACC) and the motor face region, suggesting specific effects of BTX on motor behavior.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Dermatology
Pedram Noormohammadpour, Amirhooshang Ehsani, Hamidreza Mahmoudi, Zahra Razavi, Kamran Balighi, Pedram Molhem Azar, Alireza Firooz, Asma Jabbari
Summary: This study evaluated the efficacy of botulinum toxin injection, either alone or in combination with Profhilo gel for neck rejuvenation. The results showed that the combination treatment group had significantly better hydration and skin thickness compared to the control group, and also achieved better global aesthetic improvement scores.
DERMATOLOGIC THERAPY
(2022)
Review
Food Science & Technology
Helene Moron, Corine Gagnard-Landra, David Guiraud, Arnaud Dupeyron
Summary: Botulinum toxin-A affects neuromuscular junctions and single-fiber electromyography is helpful for diagnosing NMJ impairments. The jitter parameter may have some value in predicting the clinical efficacy of BoNT-A.
Article
Biology
Yifu Han, Chun Chien, Pragya Goel, Kaikai He, Cristian Pinales, Christopher Buser, Dion Dickman
Summary: In this study, the researchers used the Drosophila larval neuromuscular junction as a model system to separate neurotransmission between tonic and phasic neurons using botulinum neurotoxin BoNT-C. They also identified heterosynaptic plasticity rules in this circuit.
Review
Otorhinolaryngology
Natalie Anne Watson, Zohaib Siddiqui, Benjamin John Miller, Yakubu Karagama, Nicholas Gibbins
Summary: This article provides an overview of the extensive use of botulinum toxin in various conditions affecting the head and neck, including dystonia, multiple system atrophy, migraines, and others. The article aims to help ENT surgeons understand the range of applications for botulinum toxin in this area.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Dermatology
Jeremy B. Green, Kavita Mariwalla, Kyle Coleman, Glynis Ablon, Susan H. Weinkle, Conor J. Gallagher, Domenico Vitarella, Roman G. Rubio
Summary: The study evaluated the safety of DaxibotulinumtoxinA for Injection (DAXI) for moderate or severe glabellar lines in a large group of subjects. Results showed that treatment-related adverse events occurred in 17.8% of subjects, with eyelid ptosis in 0.9% of treatments, all of which were generally mild and resolved. The safety profile of DAXI in this study confirmed the findings from the pivotal Phase 3 trials, providing reassurance in its overall safety profile.
DERMATOLOGIC SURGERY
(2021)