Review
Chemistry, Medicinal
Fiaz Alam, Kinza Mohammadin, Zainab Shafique, Sayyeda Tayyeba Amjad, Mohammad Hassham Hassan bin Asad
Summary: Plants from the Rutaceae family are known for their significant contributions to both food and medicine, particularly through the production of flavonoids. A systematic review conducted up to 2018 revealed a wide range of flavonoids with various bioactivities, such as anticancer, antibacterial, antiviral, analgesic, and antioxidant properties. The isolation and study of these flavonoids from Rutaceae plants could have important implications for future nutraceutical, therapeutic, and pharmaceutical developments.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Isaraporn Polbuppha, Virayu Suthiphasilp, Tharakorn Maneerat, Rawiwan Charoensup, Thunwadee Limtharakul, Sarot Cheenpracha, Stephen G. Pyne, Surat Laphookhieo
Summary: Phytochemical investigation of Maclura cochinchinensis fruit and leaf extracts led to the isolation of new compounds, some of which exhibited promising antibacterial activities against Gram-positive bacteria.
Article
Plant Sciences
Shulin Tian, Yuyan Yang, Tao Wu, Chuan Luo, Xin Li, Xijuan Zhao, Wanpeng Xi, Xiaogang Liu, Ming Zeng
Summary: This study identified two kumquat FNSII genes, with FcFNSII-2 directly synthesizing apigenin and acacetin from naringenin and isosakuranetin, respectively. Overexpression of FcFNSII-2 enhanced the transcription of structural genes and the accumulation of O-glycosyl flavones in kumquat peels.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Plant Sciences
Zhixin Zhang, Lin Yang, Jiaming Hou, Shaokai Tian, Ying Liu
Summary: Licorice flavonoids demonstrate anticancer activities by inhibiting cancer cells through regulating cell cycle and multiple signaling pathways. They have pleiotropic effects on cell growth, survival, and signaling, showing great therapeutic potential in cancer treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Oncology
Manaal Siddiqui, Basma Abdellatif, Kevin Zhai, Alena Liskova, Peter Kubatka, Dietrich Busselberg
Summary: Flavonoids show promising potential in treating CIPN by reducing oxidative stress, inflammation, and neuronal damage. Further research is needed to evaluate the efficacy and side effects of flavonoids in human models before clinical benefits can be realized.
Review
Food Science & Technology
Muhammad Imran, Farhan Saeed, Syed Amir Gilani, Mohammad Ali Shariati, Ali Imran, Muhammad Afzaal, Muhammad Atif, Tabussam Tufail, Faqir M. Anjum
Summary: Fisetin, a dietary agent found in fruits and vegetables, has shown promising anticancer activity by inhibiting cancer cell stages, preventing progression in cell cycle and growth, and inducing apoptosis. Fisetin also modulates the expressions of various proteins in cancer cell lines and suppresses several signaling pathways involved in cancer development.
FOOD SCIENCE & NUTRITION
(2021)
Review
Chemistry, Medicinal
Badar Ul Islam, Mohd Suhail, Mohammed Kaleem Khan, Torki A. Zughaibi, Raed F. Alserihi, Syed Kashif Zaidi, Shams Tabrez
Summary: Polyphenols are diverse chemical compounds found in a wide range of plants with various biological properties. Despite their broad potential activities, clinical use of polyphenols is minimal. Recent concern has been raised regarding the toxicity associated with polyphenols, highlighting the need for further high-quality studies to establish clinical efficacy and toxicology concerns.
PHYTOTHERAPY RESEARCH
(2021)
Review
Biology
Bronwyn Lok, Dinesh Babu, Yasser Tabana, Saad Sabbar Dahham, Mowaffaq Adam Ahmed Adam, Khaled Barakat, Doblin Sandai
Summary: The guava tree has long been used in traditional medicine to treat various ailments. Recent studies have shown that it exhibits anticancer activity, making it a potential alternative or adjuvant treatment for human cancers. In vitro and in vivo studies have demonstrated that extracts from the guava plant selectively suppress the growth of human cancer cells without harming normal cells. The availability of the plant also makes it a viable option for cancer treatment in developing countries.
Article
Biochemistry & Molecular Biology
Hamdoon A. Mohammed, Mohammed F. Abd El-Wahab, Usama Shaheen, Abd El-Salam Mohammed, Ashraf N. Abdalla, Ehab A. Ragab
Summary: This study successfully isolated multiple compounds from Rhamnus disperma roots, with compound 1 showing the highest cytotoxic activity against cancer cell lines and a significant selectivity towards cancer cells compared to normal cells.
Review
Biochemistry & Molecular Biology
Jolita Stabrauskiene, Dalia M. Kopustinskiene, Robertas Lazauskas, Jurga Bernatoniene
Summary: Naringin and naringenin, the main bioactive polyphenols in citrus fruits, have antioxidant and anticancer properties. They can suppress cancer development, modulate cellular signaling pathways, and have the potential to improve the condition of cancer patients.
Review
Biochemistry & Molecular Biology
Panagiota D. Pantiora, Alexandros I. Balaouras, Ioanna K. Mina, Christoforos I. Freris, Athanasios C. Pappas, Georgios P. Danezis, Evangelos Zoidis, Constantinos A. Georgiou
Summary: Pomegranate, known for its medicinal properties, contains phenolic acids, tannins, and flavonoids. The potential health benefits of pomegranate juice and by-products have attracted scientific interest, particularly in their role as potential protective agents against diseases like cancer. This review provides an update on current research on pomegranate's potential against different human diseases, with a focus on cancer. Additionally, it discusses the potential applications of pomegranate as a natural additive to improve the quality of animal products.
Article
Polymer Science
Sylwia Ronka, Aleksandra Kowalczyk, Dagmara Baczynska, Anna K. K. Zolnierczyk
Summary: This research focuses on the preparation of polymeric nanocarriers containing flavonoid-naringenin, xanthohumol, or isoxanthohumol based on Pluronics using the thin-film formation method. The study evaluates the size and stability of the formed micelles using Dynamic light scattering (DLS) analysis and demonstrates that the proposed systems effectively distribute the drug into tumor tissues, making them ideal candidates for passive targeting of cancer cells. The in vitro cytotoxicity of the flavonoids in the Pluronic formulations is investigated, and mixed polymeric micelles are designed as successful drug delivery systems.
Review
Nutrition & Dietetics
Shu Chyi Wong, Muhamad Noor Alfarizal Kamarudin, Rakesh Naidu
Summary: High-grade adult-type diffuse gliomas are the most common and deadliest malignant adult tumors of the central nervous system. Introducing dietary flavonoids to the current high-grade adult-type diffuse glioma treatment strategies is crucial to overcome the challenge of intra-tumor heterogeneity. Flavonoids have the potential to target multiple molecules associated with high-grade adult-type diffuse glioma cell proliferation, apoptosis, oxidative stress, and other key processes.
Review
Chemistry, Medicinal
Mukta Gupta, Javed Ahmad, Javed Ahamad, Snehashis Kundu, Archit Goel, Awanish Mishra
Summary: Flavonoids are natural polyphenolic compounds widely present in various food products and beverages. They have shown significant anticancer potential against different types of cancers through various mechanisms. However, their clinical translation is limited due to poor biopharmaceutical attributes. Nanoparticulate systems can be used to improve their biopharmaceutical performance and therapeutic efficacy. Further research is needed to prove their translational values.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Inorganic & Nuclear
Qing-Min Wei, Zu-Zhuang Wei, Jia-Jing Zeng, Lin Yang, Qi-Pin Qin, Ming-Xiong Tan, Hong Liang
Summary: Mitochondria-targeted novel Pt(II) complexes showed higher cytotoxicity to cisplatin-resistant cancer cells, with FB1-Pt being the most efficacious and less toxic to normal cells. This indicates their potential to overcome drug resistance in traditional cisplatin-based antitumor drugs.
Article
Chemistry, Medicinal
Shilpi Singh, Pratik Narain Srivastava, Abha Meena, Suaib Luqman
Summary: This study identified the flavonoid narirutin as a potential antagonist of miRNAs through molecular docking simulation, which disrupts the synthesis and processing of miRNA and shows potential for cancer prevention and treatment.
PHYTOTHERAPY RESEARCH
(2022)
Article
Immunology
Ravindra Jagannath Waghole, Ashwini Vivek Misar, Neha Shashikant Kulkarni, Feroz Khan, Dattatraya Gopal Naik, Sachin Hanmant Jadhav
Summary: The present study further explored the anti-inflammatory activity and antioxidative effects of T. sulcatum and found that it significantly reduced inflammation-induced oxidative damage and the expression of pro-inflammatory cytokines. This suggests that T. sulcatum may be a potential alternative anti-inflammatory medication.
INFLAMMOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Tanu Kaushal, Sana Khan, Kaneez Fatima, Suaib Luqman, Feroz Khan, Arvind Singh Negi
Summary: In this study, eleven quinoxaline derivatives were synthesized and a 2D-quantitative structural activity relationship model was developed to evaluate their anticancer activity against TNBC cells. The most potent compound, 8a, showed the best activity against TNBC cells and was found to bind within the active site of the protein target.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
K. M. Uma Kumari, Narayan Prasad Yadav, Suaib Luqman
Summary: This review focuses on the occurrence and etiology of dandruff, as well as the potential application of plant essential oils/extracts and novel treatment strategies. Current findings suggest that topical antifungals are the first line of treatment, but they have specific side effects. Alternative therapies, such as tea tree oil, thyme, and Aloe vera, have shown anti-dandruff activity by disrupting microbial growth.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mebarka Ouassaf, Ossama Daoui, Sarfaraz Alam, Souad Elkhattabi, Salah Belaidi, Samir Chtita
Summary: In this study, a computer-aided methodology combining molecular docking and pharmacophore screening was used to identify potent inhibitors against FLT3. Structure-based pharmacophore characteristics resistant to FLT3 inhibitors were identified, and two hits with potential inhibitory activity were found.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Cell Biology
Mayank Maheshwari, Nisha Yadav, Mohammad Hasanain, Praveen Pandey, Rohit Sahai, Kuldeep Choyal, Akhilesh Singh, Mushtaq A. Nengroo, Krishan K. Saini, Deepak Kumar, Kalyan Mitra, Dipak Datta, Jayanta Sarkar
Summary: The article discusses the dual function of p21 in cancer, with both inhibitory and oncogenic effects. Specifically, p21 negatively regulates basal autophagy and has oncogenic activity during early tumor development, while its inhibition promotes survival and growth of established tumors.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Aram Ko, Mohammad Hasanain, Young Taek Oh, Fulvio D'Angelo, Danika Sommer, Brulinda Frangaj, Suzanne Tran, Franck Bielle, Bianca Pollo, Rosina Paterra, Karima Mokhtari, Rajesh Kumar Soni, Matthieu Peyre, Marica Eoli, Laura Papi, Michel Kalamarides, Marc Sanson, Antonio Iavarone, Anna Lasorella
Summary: LZTR1 is a substrate-specific adaptor of a CUL3-dependent ubiquitin ligase frequently mutated in cancer. The study identified EGFR and AXL as LZTR1 substrates targeted for degradation, and found that LZTR1 mutations result in the accumulation and deregulated signaling of EGFR and AXL. The study also revealed vulnerabilities of LZTR1-mutant tumors to inhibition of EGFR and AXL, providing precision targeting for patients with LZTR1-mutant cancer.
Article
Oncology
Simona Migliozzi, Young Taek Oh, Mohammad Hasanain, Luciano Garofano, Fulvio D'Angelo, Ryan D. Najac, Alberto Picca, Franck Bielle, Anna Luisa Di Stefano, Julie Lerond, Jann N. Sarkaria, Michele Ceccarelli, Marc Sanson, Anna Lasorella, Antonio Iavarone
Summary: Proteogenomic characterization of human tumors has identified master kinases that play key roles in functional subtypes of glioblastoma. These master kinases have potential as subtype-specific therapeutic targets and can be used to inform patient selection in clinical trials. The researchers have also developed a classification tool that evaluates therapeutic response and subtype association in glioblastoma.
Article
Chemistry, Medicinal
Kripa Shankar Nainawat, Sarita Singh, Karishma Agarwal, Hina Iqbal, Poonam Rani, Divya Bhatt, Sana Khan, Debabrata Chanda, Dnyaneshwar Umrao Bawankule, Sudeep Tandon, Feroz Khan, Anil Kumar Gupta, Atul Gupta
Summary: In this study, the structural requirements for vasorelaxing activity of braylin were investigated by synthesizing different derivatives. It was found that 6-alkoxy and 6-hydroxy-alkyl amine derivatives had an impact on vasorelaxation, with 6-alkoxy derivatives being more active. Structural refinements of braylin showed that the deletion of the methoxy group or homologation beyond the ethoxy group had a deleterious effect on vasorelaxation activity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Sarita Singh, Surendra Chandra Verma, Vinay Kumar, Kriti Sharma, Diksha Singh, Sana Khan, Neelam Gupta, Romila Singh, Feroz Khan, Debabrata Chanda, Durga Prasad Mishra, Divya Singh, Partha Roy, Atul Gupta
Summary: This study presents a series of amide derivatives based on 3-aryl-3H-benzopyran that exhibit osteogenic and anticancer activities. Compound 24b showed significant osteogenic activity and effectively inhibited the growth of osteosarcoma and breast cancer cells. Mechanistic studies revealed that 24b induced apoptosis and inhibited cancer cell migration.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Satyamvada Maurya, Amita Jain, Md Tabish Rehman, Ali Hakamy, Farkad Bantun, Mohamed F. AlAjmi, Vineeta Singh, Aafreen Zehra, Feroz Khan, Shafiul Haque, Bhartendu Nath Mishra
Summary: This study aimed to identify potential new drug targets/candidates for multi-drug-resistant Mycobacterium tuberculosis (Mtb) through computational techniques. The protein structure of ribonuclease VapC2 of Mtb H37Rv was analyzed, and docking studies were performed with 22 anti-TB drugs. Rifampicin showed the best binding energy and was selected as the parent molecule for designing derivatives. One of the derivatives, RIF-155841, showed activity in inhibiting VapC2. Molecular dynamics simulations confirmed the stability of the VapC2-RIF155841 complex, and a chemical synthesis scheme was designed for future validation.
Article
Food Science & Technology
Shilpi Singh, Akhilesh Kumar Maurya, Abha Meena, Nidhi Mishra, Suaib Luqman
Summary: This study investigated the binding affinity of myricitrin to CATD and found a strong affinity. The stability of the complex was confirmed through molecular dynamics simulation, and enzyme activity studies showed inhibitory concentration. The experimental findings suggest that myricitrin could be a potential therapeutic agent for CATD-mediated lung cancer.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Waseem Raza, Abha Meena, Suaib Luqman
Summary: This study explores the potential of 3,5,7-trihydroxyflavone (THF) in inhibiting prostate cancer cell growth through reactive oxygen species (ROS) generation and also examines its tumor reduction potential in mice.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Yusuf Hussain, Jyoti Singh, Abha Meena, Rohit Anthony Sinha, Suaib Luqman
Summary: This study explores the therapeutic potential of combining escin with sorafenib and finds that the combination treatment can significantly reduce the effective dose of sorafenib and inhibit autophagy in lung cancer cells, inducing late apoptosis.
PHYTOTHERAPY RESEARCH
(2023)
Review
Chemistry, Medicinal
Anurag Mathur, Abha Meena, Suaib Luqman
Summary: Monoterpenoids, a subclass of terpenoids, have been extensively studied for their antitumor properties, including antiproliferative, apoptotic, antiangiogenic, and antimetastatic effects. This review focuses on the effects of specific monoterpenoids on metastasis and relevant signaling pathways. Monoterpenoids exhibit complexity as natural products that regulate metastatic proteins through various signaling pathways. However, limited clinical trials hinder the drug usage of monoterpenoids in preventing cancer metastasis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
