The brown bear as a translational model for sedentary lifestyle‐related diseases

Skeletal muscles of hibernating black bears show minimal atrophy and phenotype shifting despite prolonged physical inactivity and starvation

(2019) Mitsunori Miyazaki et al.   PLoS One

Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells

(2018) Stéphanie Chanon et al.   Scientific Reports

The Genome of the North American Brown Bear or Grizzly: Ursus arctos ssp. horribilis

(2018) Gregory A. Taylor et al.   Genes

Dissociation of body mass index, excess weight loss and body fat percentage trajectories after 3 years of gastric bypass: relationship with metabolic outcomes

(2017) J Gómez-Ambrosi et al.   INTERNATIONAL JOURNAL OF OBESITY

Therapy: Liraglutide — preventing or postponing T2DM diagnosis?

(2017) Tina Vilsbøll et al.   Nature Reviews Endocrinology

Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms

(2017) Frank W. Booth et al.   PHYSIOLOGICAL REVIEWS

Comparative coagulation studies in hibernating and summer-active black bears ( Ursus americanus )

(2017) Ann-Kristin U. Friedrich et al.   THROMBOSIS RESEARCH

Seasonal changes in the expression of energy metabolism-related genes in white adipose tissue and skeletal muscle in female Japanese black bears

(2016) Michito Shimozuru et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Foundations of Health and Energy Conservation in Hibernating Free-ranging Subadult Brown BearUrsus arctos

(2016) Karen Gjesing Welinder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Life in the fat lane: seasonal regulation of insulin sensitivity, food intake, and adipose biology in brown bears

(2016) K. S. Rigano et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos

(2016) Felix Sommer et al.   Cell Reports

Physiological reactions to capture in hibernating brown bears

(2016) Alina L. Evans et al.   Conservation Physiology

Suppressed bone remodeling in black bears conserves energy and bone mass during hibernation

(2015) M. McGee-Lawrence et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Low cardiac output as physiological phenomenon in hibernating, free-ranging Scandinavian brown bears (Ursus arctos) – an observational study

(2014) Peter Godsk Jørgensen et al.   Cardiovascular Ultrasound

Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study

(2014) D Canoy et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Hydrogen sulfide and nitric oxide metabolites in the blood of free-ranging brown bears and their potential roles in hibernation

(2014) Inge G. Revsbech et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comparative Genomics of Mammalian Hibernators Using Gene Networks

(2014) J. L. Villanueva-Canas et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Sex Hormone Binding Globulin Deficiency Due to a Homozygous Missense Mutation

(2014) M. J. Vos et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Comparative functional genomics of adaptation to muscular disuse in hibernating mammals

(2014) Vadim B. Fedorov et al.   MOLECULAR ECOLOGY

Translating Animal Model Research: Does It Matter That Our Rodents Are Cold?

(2014) Shane K. Maloney et al.   PHYSIOLOGY

Centers for Disease Control and Prevention. State Indicator Report on Physical Activity, 2014. Atlanta, GA: U.S. Department of Health and Human Services; 2014

(2014) Shelley McGuire   Advances in Nutrition

Decrease in the red cell cofactor 2,3-diphosphoglycerate increases hemoglobin oxygen affinity in the hibernating brown bear Ursus arctos

(2012) Inge G. Revsbech et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Sex hormone binding globulin and insulin resistance

(2012) Ian R. Wallace et al.   CLINICAL ENDOCRINOLOGY

Brown Bears (Ursus arctos) Seem Resistant to Atherosclerosis ­Despite Highly Elevated Plasma Lipids during Hibernation and Active State

(2012) Karin Arinell et al.   CTS-Clinical and Translational Science

There's more to life than rats and flies

(2012) Jessica Bolker   NATURE

Downregulation of platelet activation markers during long-term immobilization

(2012) Karin Arinell et al.   PLATELETS

Capture, Anesthesia, and Disturbance of Free-Ranging Brown Bears (Ursus arctos) during Hibernation

(2012) Alina L. Evans et al.   PLoS One

Does an early childhood intervention affect cardiometabolic risk in adulthood? Evidence from a longitudinal study of preschool attendance in South Australia

(2012) K. D'Onise et al.   PUBLIC HEALTH

Investigating the mechanism for maintaining eucalcemia despite immobility and anuria in the hibernating American black bear (Ursus americanus)

(2011) Rita L. Seger et al.   BONE

Vitamin D Status and Bone and Connective Tissue Turnover in Brown Bears (Ursus arctos) during Hibernation and the Active State

(2011) Peter Vestergaard et al.   PLoS One

Hibernation in Black Bears: Independence of Metabolic Suppression from Body Temperature

(2011) O. Toien et al.   SCIENCE

Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation in vitro

(2011) Trine Fink et al.   Stem Cell Research

"Control" laboratory rodents are metabolically morbid: Why it matters

(2010) B. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Six months of disuse during hibernation does not increase intracortical porosity or decrease cortical bone geometry, strength, or mineralization in black bear (Ursus americanus) femurs

(2009) Meghan E. McGee-Lawrence et al.   JOURNAL OF BIOMECHANICS

Structural analyses of sex hormone-binding globulin reveal novel ligands and function

(2009) George V. Avvakumov et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men

(2009) Eric L. Ding et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overcoming muscle atrophy in a hibernating mammal despite prolonged disuse in dormancy: Proteomic and molecular assessment

(2008) Kisoo Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Decreased bone turnover with balanced resorption and formation prevent cortical bone loss during disuse (hibernation) in grizzly bears (Ursus arctos horribilis)

(2007) Meghan E. McGee et al.   BONE