Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell–Mediated Antibody-Dependent Cellular Cytotoxicity

Primary human natural killer cells retain proinflammatory IgG1 at the cell surface and express CD16a glycoforms with donor-dependent variability

(2019) Kashyap R Patel et al.   MOLECULAR & CELLULAR PROTEOMICS

Antibody fucosylation lowers FcγRIIIa/CD16a affinity by limiting the conformations sampled by the N162-glycan

(2018) Daniel J. Falconer et al.   ACS Chemical Biology

IgG Glyco-Engineering to Improve IVIg Potency

(2018) Christine W. Bruggeman et al.   Frontiers in Immunology

Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile

(2017) Christine W. Bruggeman et al.   JOURNAL OF IMMUNOLOGY

Affinity of human IgG subclasses to mouse Fc gamma receptors

(2017) Gillian Dekkers et al.   mAbs

IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity

(2017) Taia T. Wang et al.   SCIENCE

IgG Fc engineering to modulate antibody effector functions

(2017) Xinhua Wang et al.   Protein & Cell

Natural Killer (NK) Cell Education Differentially Influences HIV Antibody-Dependent NK Cell Activation and Antibody-Dependent Cellular Cytotoxicity

(2017) Nicole F. Bernard et al.   Frontiers in Immunology

Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

(2017) Gillian Dekkers et al.   Frontiers in Immunology

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

(2017) Benjamin Peschke et al.   Frontiers in Immunology

Antigen specificity determines anti-red blood cell IgG-Fc alloantibody glycosylation and thereby severity of haemolytic disease of the fetus and newborn

(2016) Myrthe E. Sonneveld et al.   BRITISH JOURNAL OF HAEMATOLOGY

The immunoglobulin G1 N-glycan composition affects binding to each low affinity Fc γ receptor

(2016) Ganesh P. Subedi et al.   mAbs

Precision glycocalyx editing as a strategy for cancer immunotherapy

(2016) Han Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serological blind spots for variants of human IgG3 and IgG4 by a commonly used anti-immunoglobulin reagent

(2016) Heather L. Howie et al.   TRANSFUSION

Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity

(2015) Isaak Quast et al.   JOURNAL OF CLINICAL INVESTIGATION

Antibodies to watch in 2016

(2015) Janice M. Reichert   mAbs

Sialylation: an Avenue to Target Cancer Cells

(2015) Bhairavi N. Vajaria et al.   PATHOLOGY & ONCOLOGY RESEARCH

The Structural Role of Antibody N-Glycosylation in Receptor Interactions

(2015) Ganesh P. Subedi et al.   STRUCTURE

Low anti-RhD IgG-Fc-fucosylation in pregnancy: a new variable predicting severity in haemolytic disease of the fetus and newborn

(2014) Rick Kapur et al.   BRITISH JOURNAL OF HAEMATOLOGY

Characterization of in vitro antibody-dependent cell-mediated cytotoxicity activity of therapeutic antibodies — Impact of effector cells

(2014) Shan Chung et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D

(2014) Rick Kapur et al.   TRANSFUSION

A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy

(2013) R. Kapur et al.   BLOOD

Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer

(2013) Ajay Jain et al.   EUROPEAN JOURNAL OF CANCER

FCGR3A-158 polymorphism influences the biological response to infliximab in Crohn’s disease through affecting the ADCC activity

(2013) Rintaro Moroi et al.   IMMUNOGENETICS

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

(2013) Margaret E. Ackerman et al.   JOURNAL OF CLINICAL INVESTIGATION

High-Throughput IgG Fc N-Glycosylation Profiling by Mass Spectrometry of Glycopeptides

(2013) Maja Pučić Baković et al.   JOURNAL OF PROTEOME RESEARCH

Intranasal Administration of Antibody-Bound Respiratory Syncytial Virus Particles Efficiently Primes Virus-Specific Immune Responses in Mice

(2013) D. Kruijsen et al.   JOURNAL OF VIROLOGY

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

(2013) Jason E Hudak et al.   Nature Chemical Biology

Comparison of the Fc glycosylation of fetal and maternal immunoglobulin G

(2012) Helga K. Einarsdottir et al.   GLYCOCONJUGATE JOURNAL

Phenotypic Variation in IgG Receptors by Nonclassical FCGR2C Alleles

(2011) J. van der Heijden et al.   JOURNAL OF IMMUNOLOGY

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function of human Rh based on structure of RhCG at 2.1 A

(2010) F. Gruswitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copy number variation at theFCGRlocus includesFCGR3A, FCGR2CandFCGR3Bbut notFCGR2AandFCGR2B

(2009) Willemijn B. Breunis et al.   HUMAN MUTATION

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Regulated Glycosylation Patterns of IgG during Alloimmune Responses against Human Platelet Antigens

(2008) Manfred Wuhrer et al.   JOURNAL OF PROTEOME RESEARCH