Article
Biochemistry & Molecular Biology
Li-Chiu Yang, Yu-Chao Chang, Kun-Lin Yeh, Fu-Mei Huang, Ni-Yu Su, Yu-Hsiang Kuan
Summary: This study investigated the protective mechanism of rutin in alleviating TEGDMA-induced toxicity in macrophages. Results showed that rutin substantially reduced cytotoxicity, apoptosis, and genotoxicity, and decreased oxidative stress and ROS generation caused by TEGDMA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Cynthia Helou, Matheus Thomaz Nogueira Silva Lima, Celine Niquet-Leridon, Philippe Jacolot, Eric Boulanger, Florian Delguste, Axel Guilbaud, Michael Genin, Pauline M. Anton, Carine Delayre-Orthez, Tatiana Papazian, Michael Howsam, Frederic J. Tessier
Summary: In this study, the postprandial kinetics of CML in rodents and humans were investigated. The results showed a decrease in plasmatic sRAGE concentration and an increase in free CML concentration postprandially in humans.
Article
Chemistry, Applied
Zhi-Jing Ni, Xiang Liu, Bing Xia, Long-Teng Hu, Kiran Thakur, Zhao-Jun Wei
Summary: The study investigated the effects of camellia seed meal Maillard reaction products (MRPs) on protein structure and amino acid content, finding an increase in essential amino acids ratio and highest antioxidant activity in R-MRPs. Sensory evaluation indicated improved flavor and antioxidant activity of camellia seed meal after Maillard reaction, suggesting its potential as industrial flavoring agents.
Article
Biochemistry & Molecular Biology
Barry Halliwell
Summary: The field of oxygen free radicals, antioxidants, and reactive oxygen species (ROS) has seen significant growth, with ROS playing important roles in living organisms. However, many studies lack mechanistic meaning. Detailed understanding of the molecular mechanisms of ROS and appropriate measurement methods for both ROS and oxidative damage are necessary for progress.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mei-Hua Hu, Tien-Yu Huang, Yu-Ching Chou, Go-Shine Huang
Summary: This study found that the mixing of packed red blood cells and washed platelets had no effect on platelet ROS generation but increased the expression of CD40L. The impact of antioxidants on ROS generation and CD40L expression was not significant. Therefore, CD40L may be a valuable therapeutic target for managing transfusion reactions.
Article
Agriculture, Multidisciplinary
Arife Macit, Mevlude Kizil
Summary: This study examined the reduction effects of varying levels of olive leaf extract (0%, 0.25%, 0.5%, 1% and 2%) on the formation of heterocyclic aromatic amines (HAAs) in pan-cooked salmon at 180 and 220 degrees C.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Andrew P. Bischer, Timothy M. Baran, Andrew P. Wojtovich
Summary: Environmental surveillance-mediated behavior in Caenorhabditis elegans integrates multiple cues and is coordinated by neurons through signaling cascades. Despite lacking eyes, C. elegans is able to perceive and react to the color blue. This study explains this color perception by showing that internally-generated reactive oxygen species (ROS), in response to light, add to exogenous sources of ROS. Multiple sub-threshold sources of ROS are integrated to coordinate behavioral responses with internal cues. Blue light affects C. elegans behavior through ROS generation by endogenous flavins, mediated by the neuronal gustatory photoreceptor like protein, LITE-1. Overall, this study demonstrates that ROS and LITE-1 play central roles in C. elegans foraging behavior through integration of multiple inputs, including light.
Article
Food Science & Technology
Issei Yokoyama, Ou Setoyama, Ayumi Urakawa, Momo Sugawara, Yaqi Jia, Yusuke Komiya, Jun Nagasao, Keizo Arihara
Summary: The Maillard reaction products LG MRPs can extend the lifespan of Caenorhabditis elegans, improve age-related movement reduction, and decrease oxidative stress and fat accumulation, as well as enhance oxidative and heat stress tolerance. Additionally, LG MRPs may contribute to longevity in C. elegans by modulating the insulin/insulin-like growth factor signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Applied
Woogi Hyon, Shuji Shibata, Etsuo Ozaki, Motoki Fujimura, Suong-Hyu Hyon, Kazuaki Matsumura
Summary: We developed a self-degradable medical adhesive, LYDEX, and elucidated its degradation mechanism by analyzing the main degradation products, which is valuable for clarifying other polysaccharide hydrogel degradation mechanisms and its medical applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Plant Sciences
Yan Wang, Yaoxing Niu, Lixia Ye, Yubing Shi, Anwei Luo
Summary: The results of this study demonstrate that ozone treatment reduces respiration rate, maintains fruit hardness and storage quality, and inhibits the ripening and senescence of kiwifruit. Ozone treatment activates antioxidant enzymes and the ascorbate-glutathione cycle to prevent the accumulation of reactive oxygen species. Furthermore, ozone treatment is also related to hormone signaling, playing an important role in regulating ROS in kiwifruit.
JOURNAL OF PLANT PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Swati Sachdev, Shamim Akhtar Ansari, Mohammad Israil Ansari, Masayuki Fujita, Mirza Hasanuzzaman
Summary: Climate change has devastating effects on plants, leading to the production of reactive oxygen species (ROS) as byproducts of oxygen consumption. While excessive ROS can disrupt cellular homeostasis, moderate levels can activate growth and stress responses in plants, though the exact mechanisms are not fully understood. Advancements in modern techniques like molecular priming and crop modeling offer potential solutions for managing ROS levels in plants under stress.
Article
Food Science & Technology
Shereen N. Lotfy, Rasha Saad, Khaled F. El-Massrey, Hoda H. M. Fadel
Summary: The study found that pH values significantly influenced the generation of volatile compounds and odor profile, with low pH favoring the formation of certain compounds and high pH favoring others. Increasing pH values correlated with higher browning intensity of MRPs, while antioxidant activity and total content of free amino groups decreased gradually.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Environmental
Wang Chengwei, Liu Yihao, Yang Xiaoxiao, Li Wentao, Zhou Xianhao, Ren Ya, Zhang Changru, Yang Han, Kong Weiqing, Wang Jinwu, Niu Haoyi
Summary: In this study, an in-situ gelled and shape-adaptable hydrogel with antibacterial and ROS scavenging properties was developed for chronic diabetic wound healing. The hydrogel provided a physical barrier that protected the wounds from bacteria and promoted wound healing. It exhibited great biocompatibility, antibacterial activity, and the ability to adjust inflammation and promote collagen deposition for wound contraction and healing.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Food Science & Technology
Jiarong Cao, Haixia Yan, Ling Liu
Summary: The study found that sucrose ester and sodium bromate can inhibit the damage to non-wilted cells and promote plant adaptation to cold stress. Additionally, sugars and osmotic substances have a protective effect on non-wilted cells, potentially related to the occurrence of intercellular fluid loss and apoptosis.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)