Combination of attenuated Salmonella carrying PD‐1 siRNA with nifuroxazide for colon cancer therapy

Enhancing anti-tumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors

(2019) K M Heinhuis et al.   ANNALS OF ONCOLOGY

PD-1-siRNA delivered by attenuated Salmonella enhances the antimelanoma effect of pimozide

(2019) Tiesuo Zhao et al.   Cell Death & Disease

Disruption of CTLA-4 expression on peripheral blood CD8 + T cell enhances anti-tumor efficacy in bladder cancer

(2019) Wei Zhang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

PD/1-PD-Ls Checkpoint: Insight on the Potential Role of NK Cells

(2019) Silvia Pesce et al.   Frontiers in Immunology

Docetaxel Down-Regulates PD-1 Expression via STAT3 in T Lymphocytes

(2018) Chaoyang Zhang et al.   Clinical Lung Cancer

STAT3 Interactors as Potential Therapeutic Targets for Cancer Treatment

(2018) Federica Laudisi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tea Polysaccharides Inhibit Colitis-Associated Colorectal Cancer via Interleukin-6/STAT3 Pathway

(2018) Li Qiao Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cooperativity of HOXA5 and STAT3 Is Critical for HDAC8 Inhibition-Mediated Transcriptional Activation of PD-L1 in Human Melanoma Cells

(2018) Yu Fang Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Immune Checkpoint Inhibitors to Treat Malignant Lymphomas

(2018) Magdalena Witkowska et al.   Journal of Immunology Research

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

(2018) Tammy Linlin Song et al.   BLOOD

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Stromal PD-1 / PD-L1 expression predicts outcome in colon cancer patients

(2018) Jacqueline Wyss et al.   Clinical Colorectal Cancer

PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

(2018) Lindsay J. Celada et al.   Science Translational Medicine

Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3

(2018) Song Wu et al.   Frontiers in Pharmacology

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

(2018) Razvan Cristescu et al.   SCIENCE

Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma

(2018) Lukas W. Pfannenstiel et al.   OncoImmunology

Primary and acquired resistance to PD-1/PD-L1 blockade in cancer treatment

(2017) Qiaohong Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

STAT3 Induces Immunosuppression by Upregulating PD-1/PD-L1 in HNSCC

(2017) L.L. Bu et al.   JOURNAL OF DENTAL RESEARCH

STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC

(2017) Qiuju Han et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft-vs.-host disease: Old drug, new use

(2017) Huijie Jia et al.   Molecular Medicine Reports

Cure in Advanced Renal Cell Cancer: Is It an Achievable Goal?

(2017) Dhanusha Sabanathan et al.   ONCOLOGIST

Nifuroxazide prompts antitumor immune response of TCL-loaded DC in mice with orthotopically-implanted hepatocarcinoma

(2017) Tiesuo Zhao et al.   ONCOLOGY REPORTS

Characterization of outcomes in patients with metastatic non-small cell lung cancer treated with programmed cell death protein 1 inhibitors past RECIST version 1.1–defined disease progression in clinical trials

(2017) Dickran Kazandjian et al.   SEMINARS IN ONCOLOGY

Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis

(2017) Ting-Hong Ye et al.   Cell Death & Disease

MDA7 combined with targeted attenuated Salmonella vector SL7207/pBud-VP3 inhibited growth of gastric cancer cells

(2016) Hongdan Cao et al.   BIOMEDICINE & PHARMACOTHERAPY

AKT-STAT3 Pathway as a Downstream Target of EGFR Signaling to Regulate PD-L1 Expression on NSCLC cells

(2016) Sherif Abdelhamed et al.   Journal of Cancer

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

(2014) S. L. Highfill et al.   Science Translational Medicine

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

(2013) Omid Hamid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antitumor effects of Stat3-siRNA and endostatin combined therapies, delivered by attenuated Salmonella, on orthotopically implanted hepatocarcinoma

(2012) Huijie Jia et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3

(2008) E. A. Nelson et al.   BLOOD