Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma

Survival of patients with melanoma brain metastasis treated with stereotactic radiosurgery and active systemic drug therapies

(2017) Ee Siang Choong et al.   EUROPEAN JOURNAL OF CANCER

Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape

(2017) Leisha A. Emens et al.   EUROPEAN JOURNAL OF CANCER

Pembrolizumab use for the treatment of advanced melanoma

(2017) Pol Specenier   EXPERT OPINION ON BIOLOGICAL THERAPY

Let This Be Our New Year's Pledge

(2017) Bruce A. Chabner et al.   ONCOLOGIST

Survival of patients with metastatic melanoma and brain metastases in the era of MAP-kinase inhibitors and immunologic checkpoint blockade antibodies: A systematic review

(2016) Francesco Spagnolo et al.   CANCER TREATMENT REVIEWS

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Analysis of the Abscopal Effect With Anti-PD1 Therapy in Patients With Metastatic Solid Tumors

(2016) Jéssica Ribeiro Gomes et al.   JOURNAL OF IMMUNOTHERAPY

Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology

(2016) Amy K. LeBlanc et al.   Science Translational Medicine

Immunotherapy of Brain Cancer

(2016) Patrick Roth et al.   Oncology Research and Treatment

Systemic Immunotherapy for the Treatment of Brain Metastases

(2016) Justine V. Cohen et al.   Frontiers in Oncology

Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy

(2016) Kristina H. Young et al.   PLoS One

Clinical outcomes of melanoma brain metastases treated with stereotactic radiation and anti-PD-1 therapy

(2015) K. A. Ahmed et al.   ANNALS OF ONCOLOGY

Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling

(2015) J. Man et al.   CANCER RESEARCH

The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant

(2015) Kobe Reynders et al.   CANCER TREATMENT REVIEWS

Stereotactic Radiosurgery for Melanoma Brain Metastases in Patients Receiving Ipilimumab: Safety Profile and Efficacy of Combined Treatment

(2015) Ana P. Kiess et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain

(2015) Abeba Demelash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial

(2015) Antoni Ribas et al.   LANCET ONCOLOGY

Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial

(2015) Jeffrey S Weber et al.   LANCET ONCOLOGY

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

(2015) Stephen M. Ansell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 Restrains Radiotherapy-Induced Abscopal Effect

(2015) S. S. Park et al.   Cancer Immunology Research

Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases

(2015) Anna S Berghoff et al.   OncoImmunology

Tumour-infiltrating CD4+ and CD8+ lymphocytes as predictors of clinical outcome in glioma

(2014) S Han et al.   BRITISH JOURNAL OF CANCER

Insulin, Estrogen, Inflammatory Markers, and Risk of Benign Proliferative Breast Disease

(2014) C. Catsburg et al.   CANCER RESEARCH

Anti-VEGF Antibodies Mitigate the Development of Radiation Necrosis in Mouse Brain

(2014) X. Jiang et al.   CLINICAL CANCER RESEARCH

The Effect of Radiation on the Immune Response to Cancers

(2014) Bonggoo Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

(2014) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

(2014) Thomas Powles et al.   NATURE

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Multiple murine BRafV600Emelanoma cell lines with sensitivity to PLX4032

(2014) Molly H. Jenkins et al.   Pigment Cell & Melanoma Research

Sema3C Promotes the Survival and Tumorigenicity of Glioma Stem Cells through Rac1 Activation

(2014) Jianghong Man et al.   Cell Reports

α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets

(2014) Veit Rothhammer et al.   Acta Neuropathologica Communications

Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer

(2013) François Vaillant et al.   CANCER CELL

Abscopal effect of radiation therapy: Interplay between radiation dose and p53 status

(2013) Lidia Strigari et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Disabling Immune Tolerance by Programmed Death-1 Blockade With Pidilizumab After Autologous Hematopoietic Stem-Cell Transplantation for Diffuse Large B-Cell Lymphoma: Results of an International Phase II Trial

(2013) Philippe Armand et al.   JOURNAL OF CLINICAL ONCOLOGY

Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours

(2013) Jérôme Galon et al.   JOURNAL OF PATHOLOGY

MHC class I–restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8+ T cells

(2013) Qingyong Ji et al.   NATURE IMMUNOLOGY

Concurrent Radiotherapy and Ipilimumab Immunotherapy for Patients with Melanoma

(2013) C. A. Barker et al.   Cancer Immunology Research

Immunogenic Tumor Cell Death Induced by Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma

(2012) Yoshiyuki Suzuki et al.   CANCER RESEARCH

Blockade of Myeloid-Derived Suppressor Cells after Induction of Lymphopenia Improves Adoptive T Cell Therapy in a Murine Model of Melanoma

(2012) K. N. Kodumudi et al.   JOURNAL OF IMMUNOLOGY

Radiosurgery for melanoma brain metastases in the ipilimumab era and the possibility of longer survival

(2012) Jonathan P. S. Knisely et al.   JOURNAL OF NEUROSURGERY

Melanoma in the brain

(2012) Geoffrey Thomas Gibney et al.   MELANOMA RESEARCH

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

(2012) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2

(2011) Christine E. Eyler et al.   CELL

Determinants of Successful CD8 + T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice

(2011) Christopher A. Klebanoff et al.   CLINICAL CANCER RESEARCH

Prognostic and Clinicopathologic Associations of OncogenicBRAFin Metastatic Melanoma

(2011) Georgina V. Long et al.   JOURNAL OF CLINICAL ONCOLOGY

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain

(2011) Niroshana Anandasabapathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis

(2010) J.-H. Lee et al.   BRITISH JOURNAL OF DERMATOLOGY

Prognostic factors for survival in melanoma patients with brain metastases

(2010) Michael A. Davies et al.   CANCER

Outcome predictors of Gamma Knife surgery for melanoma brain metastases

(2010) Donald N. Liew et al.   JOURNAL OF NEUROSURGERY

Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference

(2010) Britta Wahren et al.   Journal of Translational Medicine

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

Functions of γC cytokines in immune homeostasis: Current and potential clinical applications

(2009) Willem W. Overwijk et al.   CLINICAL IMMUNOLOGY

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Enhancement of Antitumor Radiation Efficacy and Consistent Induction of the Abscopal Effect in Mice by ECI301, an Active Variant of Macrophage Inflammatory Protein-1 

(2008) K. Shiraishi et al.   CLINICAL CANCER RESEARCH

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells

(2007) I. Ifergan et al.   BRAIN