Comparative kinetic isotope effects on first- and second-order rate constants of soybean lipoxygenase variants uncover a substrate-binding network

Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The “Undoing” of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network

(2019) Shenshen Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding Biological Hydrogen Transfer Through the Lens of Temperature Dependent Kinetic Isotope Effects

(2018) Judith P. Klinman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Hydrogen–deuterium exchange reveals long-range dynamical allostery in soybean lipoxygenase

(2017) Adam R. Offenbacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origins of Enzyme Catalysis: Experimental Findings for C–H Activation, New Models, and Their Relevance to Prevailing Theoretical Constructs

(2017) Judith P. Klinman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

13C ENDOR Spectroscopy of Lipoxygenase–Substrate Complexes Reveals the Structural Basis for C–H Activation by Tunneling

(2017) Masaki Horitani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhanced Rigidification within a Double Mutant of Soybean Lipoxygenase Provides Experimental Support for Vibronically Nonadiabatic Proton-Coupled Electron Transfer Models

(2017) Shenshen Hu et al.   ACS Catalysis

Hydrogen–Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling

(2017) Adam R. Offenbacher et al.   ACS Central Science

Hydrostatic Pressure Studies Distinguish Global from Local Protein Motions in C−H Activation by Soybean Lipoxygenase-1

(2016) Shenshen Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic Detection of Orthogonal Protein and Chemical Coordinates in Enzyme Catalysis: Double Mutants of Soybean Lipoxygenase

(2015) Sudhir C. Sharma et al.   BIOCHEMISTRY

Active Site Dynamical Effects in the Hydrogen Transfer Rate-limiting Step in the Catalysis of Linoleic Acid by Soybean Lipoxygenase-1 (SLO-1): Primary and Secondary Isotope Contributions

(2015) Prasad Phatak et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The structural basis for specificity in lipoxygenase catalysis

(2015) Marcia E. Newcomer et al.   PROTEIN SCIENCE

Dynamically Achieved Active Site Precision in Enzyme Catalysis

(2014) Judith P. Klinman   ACCOUNTS OF CHEMICAL RESEARCH

Role of Dynamics in Enzyme Catalysis: Substantial versus Semantic Controversies

(2014) Amnon Kohen   ACCOUNTS OF CHEMICAL RESEARCH

Fluctuations of an Exposed π-Helix Involved in Lipoxygenase Substrate Recognition

(2014) Miles D. Bradshaw et al.   BIOCHEMISTRY

Extremely Elevated Room-Temperature Kinetic Isotope Effects Quantify the Critical Role of Barrier Width in Enzymatic C–H Activation

(2014) Shenshen Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen Tunneling Links Protein Dynamics to Enzyme Catalysis

(2013) Judith P. Klinman et al.   Annual Review of Biochemistry

Importance of Protein Dynamics during Enzymatic C–H Bond Cleavage Catalysis

(2013) Judith P. Klinman   BIOCHEMISTRY

The kinetics of invertin action

(2013) L. Michaelis et al.   FEBS LETTERS

Fast Protein Motions Are Coupled to Enzyme H-Transfer Reactions

(2013) Christopher R. Pudney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Locating a Lipid at the Portal to the Lipoxygenase Active Site

(2012) Betty J. Gaffney et al.   BIOPHYSICAL JOURNAL

Impact of Distal Mutation on Hydrogen Transfer Interface and Substrate Conformation in Soybean Lipoxygenase

(2010) Sarah J. Edwards et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Kinetic and Structural Investigations of the Allosteric Site in Human Epithelial 15-Lipoxygenase-2

(2009) Aaron T. Wecksler et al.   BIOCHEMISTRY

Enzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (I553) in soybean lipoxygenase-1

(2008) M. P. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA