Antisense inhibition of lpxB gene expression in Acinetobacter baumannii by peptide–PNA conjugates and synergy with colistin

Investigation of novel pmrB and eptA mutations in isogenic Acinetobacter baumannii isolates associated with colistin resistance and increased virulence in vivo

(2019) Stefanie Gerson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bridged Nucleic Acids Reloaded

(2019) Alfonso Soler-Bistué et al.   MOLECULES

Involvement of HisF in the Persistence of Acinetobacter baumannii During a Pneumonia Infection

(2019) Marta Martínez-Guitián et al.   Frontiers in Cellular and Infection Microbiology

Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli

(2018) Thomas E. Bohl et al.   Nature Communications

Phenotypic changes associated with Colistin resistance due to Lipopolysaccharide loss in Acinetobacter baumannii

(2018) Marta Carretero-Ledesma et al.   Virulence

Pneumonia infection in mice reveals the involvement of the feoA gene in the pathogenesis of Acinetobacter baumannii

(2018) Laura Álvarez-Fraga et al.   Virulence

Potent Antibacterial Antisense Peptide–Peptide Nucleic Acid Conjugates Against Pseudomonas aeruginosa

(2018) Anubrata Ghosal et al.   Nucleic Acid Therapeutics

UDP-N-Acetylglucosamine enolpyruvyl transferase (MurA) of Acinetobacter baumannii (AbMurA): Structural and functional properties

(2017) Amit Sonkar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Peptide nucleic acid antisense oligomers open an avenue for developing novel antibacterial molecules

(2017) Anubrata Ghosal   Journal of Infection in Developing Countries

Antibacterial Peptide Nucleic Acid–Antimicrobial Peptide (PNA–AMP) Conjugates: Antisense Targeting of Fatty Acid Biosynthesis

(2016) Anna Mette Hansen et al.   BIOCONJUGATE CHEMISTRY

Inhibition of AAC(6′)-Ib-Mediated Resistance to Amikacin in Acinetobacter baumannii by an Antisense Peptide-Conjugated 2′,4′-Bridged Nucleic Acid-NC-DNA Hybrid Oligomer

(2015) Christina Lopez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies

(2015) Graham McClorey et al.   CURRENT OPINION IN PHARMACOLOGY

Antibacterial Activity of Novel Cationic Peptides against Clinical Isolates of Multi-Drug Resistant Staphylococcus pseudintermedius from Infected Dogs

(2015) Mohamed F. Mohamed et al.   PLoS One

Inhibition of gene expression and growth of multidrug-resistant Acinetobacter baumannii by antisense peptide nucleic acids

(2014) Huijuan Wang et al.   MOLECULAR BIOLOGY REPORTS

Species-Selective Killing of Bacteria by Antimicrobial Peptide-PNAs

(2014) Madhav Mondhe et al.   PLoS One

Growth Retardation, Reduced Invasiveness, and Impaired Colistin-Mediated Cell Death Associated with Colistin Resistance Development in Acinetobacter baumannii

(2013) Spyros Pournaras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biological Cost of Different Mechanisms of Colistin Resistance and Their Impact on Virulence in Acinetobacter baumannii

(2013) Alejandro Beceiro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Growth and Gene Expression by PNA-peptide Conjugates in Streptococcus pyogenes

(2013) Nadja Patenge et al.   Molecular Therapy-Nucleic Acids

In VitroActivity of Telavancin in Combination with Colistin versus Gram-Negative Bacterial Pathogens

(2012) Michael Hornsey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

(2012) Ryszard Kole et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of LpxC Protects Mice from Resistant Acinetobacter baumannii by Modulating Inflammation and Enhancing Phagocytosis

(2012) L. Lin et al.   mBio

Phosphoethanolamine Modification of Lipid A in Colistin-Resistant Variants of Acinetobacter baumannii Mediated by the pmrAB Two-Component Regulatory System

(2011) Alejandro Beceiro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antisense inhibition of gene expression and growth in gram-negative bacteria by cell-penetrating peptide conjugates of peptide nucleic acids targeted to rpoD gene

(2011) Hui Bai et al.   BIOMATERIALS

Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance

(2011) A.-P. Magiorakos et al.   CLINICAL MICROBIOLOGY AND INFECTION

Bacteriostatic versus bactericidal activity of ciprofloxacin in Escherichia coli assessed by flow cytometry using a novel far-red dye

(2011) Filomena Silva et al.   JOURNAL OF ANTIBIOTICS

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

(2010) J. H. Moffatt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Activity and In Vivo Efficacy of Clavulanic Acid against Acinetobacter baumannii

(2009) A. Beceiro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Resistance to Colistin in Acinetobacter baumannii Associated with Mutations in the PmrAB Two-Component System

(2009) M. D. Adams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cationic phosphorodiamidate morpholino oligomers efficiently prevent growth of Escherichia coli in vitro and in vivo

(2009) Brett L. Mellbye et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Concurrent Growth Rate and Transcript Analyses Reveal Essential Gene Stringency in Escherichia coli

(2009) Shan Goh et al.   PLoS One

Acinetobacter baumannii: Emergence of a Successful Pathogen

(2008) A. Y. Peleg et al.   CLINICAL MICROBIOLOGY REVIEWS

Tackling antibiotic resistance: a dose of common antisense?

(2008) N. Woodford et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY