Resveratrol and Metformin Recover Prefrontal Cortex AMPK Activation in Diet-Induced Obese Mice but Reduce BDNF and Synaptophysin Protein Content

Increased Tau Phosphorylation and Impaired Brain Insulin/IGF Signaling in Mice Fed a High Fat/High Cholesterol Diet

(2018) Narayan R. Bhat et al.   JOURNAL OF ALZHEIMERS DISEASE

Diabesity and brain disturbances: A metabolic perspective

(2018) Susana Cardoso et al.   MOLECULAR ASPECTS OF MEDICINE

Triglycerides cross the blood–brain barrier and induce central leptin and insulin receptor resistance

(2017) W A Banks et al.   INTERNATIONAL JOURNAL OF OBESITY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Metformin – a Future Therapy for Neurodegenerative Diseases

(2017) Magdalena Markowicz-Piasecka et al.   PHARMACEUTICAL RESEARCH

Antiaging Effect of Metformin on Brain in Naturally Aged and Accelerated Senescence Model of Rat

(2017) Geetika Garg et al.   REJUVENATION RESEARCH

AMPK as a Therapeutic Target for Treating Metabolic Diseases

(2017) Emily A. Day et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die

(2016) Jee-Yeon Hwang et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress in Alzheimer disease and mild cognitive impairment: evidence from human data provided by redox proteomics

(2015) Aaron M. Swomley et al.   ARCHIVES OF TOXICOLOGY

Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice

(2015) R. E. K. MacPherson et al.   JOURNAL OF APPLIED PHYSIOLOGY

A high-sugar high-fat diet induced metabolic syndrome shows some symptoms of Alzheimer’s disease in rats

(2015) L. Niu et al.   Journal of Nutrition Health & Aging

In Vivo AAV1 Transduction With hRheb(S16H) Protects Hippocampal Neurons by BDNF Production

(2015) Min-Tae Jeon et al.   MOLECULAR THERAPY

Abnormal Glucose Metabolism in Alzheimer’s Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches

(2015) Kalpita Banerjee et al.   NEUROCHEMICAL RESEARCH

Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases

(2014) Martine Uittenbogaard et al.   CURRENT PHARMACEUTICAL DESIGN

Inhibition of AMP-Activated Protein Kinase Signaling Alleviates Impairments in Hippocampal Synaptic Plasticity Induced by Amyloid  

(2014) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

(2014) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex

(2014) Moritz M. Hettich et al.   PLoS One

Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis

(2014) Heidi E. Kocalis et al.   Molecular Metabolism

Noninvasive and Targeted Drug Delivery to the Brain Using Focused Ultrasound

(2013) Alison Burgess et al.   ACS Chemical Neuroscience

Resveratrol supplementation improves white adipose tissue function in a depot-specific manner in Zucker diabetic fatty rats

(2013) Marie-Soleil Beaudoin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AMPK activation regulates neuronal structure in developing hippocampal neurons

(2013) S. Ramamurthy et al.   NEUROSCIENCE

Two Weeks of Metformin Treatment Enhances Mitochondrial Respiration in Skeletal Muscle of AMPK Kinase Dead but Not Wild Type Mice

(2013) Jonas M. Kristensen et al.   PLoS One

Continuation of Exercise Is Necessary to Inhibit High Fat Diet-Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2013) Masato Maesako et al.   PLoS One

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2012) Masato Maesako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retrograde Changes in Presynaptic Function Driven by Dendritic mTORC1

(2012) F. E. Henry et al.   JOURNAL OF NEUROSCIENCE

Roles of AMP-activated Protein Kinase in Alzheimer’s Disease

(2012) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Amyloid Precursor Protein and Proinflammatory Changes Are Regulated in Brain and Adipose Tissue in a Murine Model of High Fat Diet-Induced Obesity

(2012) Kendra L. Puig et al.   PLoS One

Bioavailability of resveratrol

(2011) Thomas Walle   Annals of the New York Academy of Sciences

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice

(2011) Masato Maesako et al.   NEUROBIOLOGY OF AGING

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

Protective effect of metformin in CD1 mice placed on a high carbohydrate–high fat diet

(2010) Min Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK

(2010) Wyatt B. Potter et al.   PLoS One

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

mTOR phosphorylated at S2448 binds to raptor and rictor

(2009) M. Rosner et al.   AMINO ACIDS

Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders

(2009) Louis A. Profenno et al.   BIOLOGICAL PSYCHIATRY

AMPK in the brain: its roles in energy balance and neuroprotection

(2009) Gabriele V. Ronnett et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD

(2008) Ellen L. Robb et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

(2008) Lakshmi Thirumangalakudi et al.   JOURNAL OF NEUROCHEMISTRY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis

(2008) M. A. Beydoun et al.   Obesity Reviews