Article
Veterinary Sciences
Paul L. Wood, Lynda M. J. Miller
Summary: The liquid tear film is a dynamic fluid containing complex lipids to protect the eyes. Infections can disrupt lipids and lead to eye damage and blindness. This study found that pink eye infections significantly decrease lipid levels in the tear film of cattle, which may contribute to the development of blindness in infected cattle.
VETERINARY SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Antia Custodia, Daniel Romaus-Sanjurjo, Marta Aramburu-Nunez, Diego Alvarez-Rafael, Laura Vazquez-Vazquez, Javier Camino-Castineiras, Yago Leira, Juan Manuel Pias-Peleteiro, Jose Manuel Aldrey, Tomas Sobrino, Alberto Ouro
Summary: This review focuses on the most relevant findings related to ceramide and neurodegeneration, particularly in Alzheimer's disease (AD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anders K. Nilsson, Mats X. Andersson, Ulrika Sjobom, Gunnel Hellgren, Pia Lundgren, Aldina Pivodic, Lois E. H. Smith, Ann Hellstrom
Summary: The study revealed significant changes in the serum phospho- and sphingolipidome of extremely preterm infants during the first weeks of life. Low levels of the signaling lipid sphingosine-1-phosphate are associated with the development of severe ROP.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Camillo Morano, Aida Zulueta, Anna Caretti, Gabriella Roda, Rita Paroni, Michele Dei Cas
Summary: This study explores various pre-analytical procedures, extraction methods, and derivatization steps in targeted sphingolipidomics to improve sensitivity and accuracy of sphingolipid analysis. It is recommended to analyze sphingolipids and sphingoid bases under different chromatographic conditions to avoid interferences.
Article
Biochemistry & Molecular Biology
Zhibo Gai, Sophia L. Samodelov, Irina Alecu, Thorsten Hornemann, Jane I. Grove, Guruprasad P. Aithal, Michele Visentin, Gerd A. Kullak-Ublick
Summary: Sphingolipid metabolism may be involved in the onset and progression of drug-induced liver injury (DILI), as evidenced by perturbations in plasma sphingolipid profiles in DILI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Essa M. Saied, Christoph Arenz
Summary: Sphingolipids are a class of compounds ubiquitous in eukaryotic plasma membranes, playing important roles in human and animal physiology and disease. Research into these 'Sphinx' lipids is hindered by their low concentrations and the lack of suitable standards, highlighting the need for the development of efficient and facile synthesis methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Antia Custodia, Marta Aramburu-Nunez, Clara Correa-Paz, Adrian Posado-Fernandez, Ana Gomez-Larrauri, Jose Castillo, Antonio Gomez-Munoz, Tomas Sobrino, Alberto Ouro
Summary: This article summarizes the role of ceramide in cellular processes and highlights its importance in neurodegenerative diseases, particularly in Parkinson's disease.
Article
Nutrition & Dietetics
Zhenying Hu, Jingjing Duan
Summary: This review explores the presence of 1-deoxySLs and their analogs in the diet, as well as their potential physiological and pathophysiological aspects. It highlights the mysteries and research gaps surrounding 1-deoxySLs as dietary and endogenously produced components.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2022)
Review
Immunology
Johanna Rohrhofer, Benjamin Zwirzitz, Evelyne Selberherr, Eva Untersmayr
Summary: The large surfaces of gastrointestinal organs are adapted to their tasks of nutritional uptake and defense, with immune cells within the mucosa regulating a balance to prevent inflammation. An increase in GI disorders in Western societies is linked to dietary changes and gut microbiome imbalance, leading to chronic inflammation. Understanding the mechanisms of immuno-nutrition and the impact of dietary compounds on gut immune homeostasis is essential for disease prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Ilona Juchnicka, Mariusz Kuzmicki, Jacek Szamatowicz
Summary: Obesity is a growing global concern, significantly contributing to the development of diseases like type 2 diabetes and cardiovascular disorders. Excessive lipid accumulation in tissues leads to inflammation and metabolic dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Nutrition & Dietetics
Catherine Calzada, Cecile Vors, Armelle Penhoat, David Cheillan, Marie-Caroline Michalski
Summary: Sphingolipids, as structural components and signaling molecules, play important roles in cell membranes and lipoproteins, and are implicated in metabolic and cardiovascular diseases. Dietary lipids can modulate circulating sphingolipids and lipid-related cardiovascular risk markers. Saturated fatty acids may increase ceramide concentrations, while milk polar lipids may decrease certain species of sphingomyelins and ceramides in plasma and chylomicrons. Understanding the impact of different dietary fatty acids and lipid species on circulating sphingolipids can guide the development of nutritional strategies for preventing cardiovascular diseases.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Jean-Philip Truman, Christian F. Ruiz, Magali Trayssac, Cungui Mao, Yusuf A. Hannun, Lina M. Obeid
Summary: This study reveals that under conditions of serine starvation, SK1 is degraded in a p53-independent manner, requiring the action of the proteasome. Overexpression of SK1 to compensate for its loss is detrimental to cell growth under serine deprivation, indicating that suppression of SK1 under these conditions is adaptive. The effects of SK1 suppression on intracellular reactive oxygen species were mimicked by D-erythro-sphingosine, suggesting that the accumulation of its substrate, sphingosine, is responsible for these effects.
Review
Biochemistry & Molecular Biology
Beatrice Arosio, Graziamaria Corbi, Sergio Davinelli, Vienna Giordano, Daniela Liccardo, Antonio Rapacciuolo, Alessandro Cannavo
Summary: The medical community recognizes sex-related differences in cardiovascular disease outcomes, with pre-menopausal women generally having a better prognosis than men. Estrogens have been identified as one of the leading factors driving these differences, but estrogen replacement therapy can have adverse effects. Further research is needed to understand estrogen-related mechanisms for better prevention and treatment of cardiovascular disease in women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Duyen Tran, Stephen Myers, Courtney McGowan, Darren Henstridge, Rajaraman Eri, Sabrina Sonda, Vanni Caruso
Summary: 1-DSL disrupts the functionality of skeletal muscle cells, likely contributing to the muscle dysfunction detected in patients with Type 2 diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Kazushi Ohta, Shinobu Hiraki, Masakatsu Miyanabe, Tatsuro Ueki, Kazuhiko Aida, Yuki Manabe, Tatsuya Sugawara
Summary: This study evaluated the absorption and metabolism of dietary ceramides and glucosylceramides in mouse plasma after oral administration using LC-MS/MS analysis. The results suggest that dietary ceramides and glucosylceramides are partly absorbed as intact molecules or hydrolysates.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biology
Xiaowen Liu, Thuy Vien, Jingjing Duan, Shu-Hsien Sheu, Paul G. DeCaen, David E. Clapham
Article
Multidisciplinary Sciences
Jingjing Duan, Zongli Li, Jian Li, Raymond E. Hulse, Ana Santa-Cruz, William C. Valinsky, Sunday A. Abiria, Grigory Krapivinsky, Jin Zhang, David E. Clapham
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Jingjing Duan, Jian Li, Gui-Lan Chen, Yan Ge, Jieyu Liu, Kechen Xie, Xiaogang Peng, Wei Zhou, Jianing Zhong, Yixing Zhang, Jie Xu, Changhu Xue, Bo Liang, Lan Zhu, Wei Liu, Cheng Zhang, Xiao-Li Tian, Jianbin Wang, David E. Clapham, Bo Zeng, Zongli Li, Jin Zhang
Article
Immunology
Espen Melum, Xiaojun Jiang, Kristi D. Baker, M. Fatima Macedo, Juergen Fritsch, C. Marie Dowds, Jing Wang, Anne Pharo, Arthur Kaser, Corey Tan, Catia S. Pereira, Samuel L. Kelly, Jingjing Duan, Tom H. Karlsen, Mark A. Exley, Stefan Schuetze, Dirk M. Zajonc, Alfred H. Merrill, Edward H. Schuchman, Sebastian Zeissig, Richard S. Blumberg
Article
Biochemistry & Molecular Biology
Lucie I. Pisella, Jean-Luc Gaiarsa, Diabe Diabira, Jinwei Zhang, Ilgam Khalilov, JingJing Duan, Kristopher T. Kahle, Igor Medina
Article
Biochemistry & Molecular Biology
Miho Watanabe, Jinwei Zhang, M. Shahid Mansuri, Jingjing Duan, Jason K. Karimy, Eric Delpire, Seth L. Alper, Richard P. Lifton, Atsuo Fukuda, Kristopher T. Kahle
Letter
Biology
Xuelan Zhou, Fanglin Zhong, Cheng Lin, Xiaohui Hu, Yan Zhang, Bing Xiong, Xiushan Yin, Jinheng Fu, Wei He, Jingjing Duan, Yang Fu, Huan Zhou, Peter J. McCormick, Qisheng Wang, Jian Li, Jin Zhang
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Fisheries
Rongbin Ding, Lei Liu, Zhenying Hu, Andong Wu, Huaiyi Zhu, Qingxin Ruan, Huiming Qiu, Yijiang Hong, Beijuan Hu, Jingjing Duan
Summary: This study introduces a noninvasive and rapid method using micro-CT to evaluate the quantity, size, and growth rate of pearls in living freshwater mussels. The method successfully detects overall shapes and amount of pearls, and accurate dimension-measurements of cultured pearls were achieved through micro-CT quantitative analysis. This in vivo pearl evaluation does not affect subsequent growth of scanned shellfish.
Editorial Material
Multidisciplinary Sciences
Jian Li, Xuelan Zhou, Yan Zhang, Fanglin Zhong, Cheng Lin, Peter J. McCormick, Feng Jiang, Jun Luo, Huan Zhou, Qisheng Wang, Yang Fu, Jingjing Duan, Jin Zhang
Article
Chemistry, Multidisciplinary
Yuntong Sun, Shan Ding, Baokai Xia, Jingjing Duan, Markus Antonietti, Sheng Chen
Summary: It has long been believed that FeMoS structure plays a crucial role in electrochemical nitrogen fixation, but the structure of Fe bonded with heavier analogues (Se or Te) has never been explored. However, this study, based on theoretical predictions, discovers that the FeMo(Se, Te) structure, with Fe bonded to Se, exhibits enhanced N-2 electrofixation activities. Further mechanism studies provide new clues for designing versatile electrocatalytic materials for large-scale industrialization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Xiaojing Song, Jian Li, Miao Tian, Huaiyi Zhu, Xiaohui Hu, Yuting Zhang, Yanru Cao, Heyang Ye, Peter J. McCormick, Bo Zeng, Yang Fu, Jingjing Duan, Jin Zhang
Summary: In this study, the cryo-EM structure of the full-length mouse TRPML2 was determined, providing new insights into the molecular mechanism and diversity of TRPML channels. The structure revealed an inactive conformation and unique features of TRPML2, contributing to our understanding of ion-conducting pathways and pH conditions.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Zhenying Hu, Yue Chen, Xuan Wang, Yaojun Deng, Xin Wang, Shaobo Li, Xia Ding, Jingjing Duan
Summary: In this study, a group of novel metabolites of 2-AOD-3-ol were discovered from F. avenaceum-fermented rice culture. The accumulation of these fusarium toxins was observed in rice, grapes, apples, and oranges during storage. This finding provides insight into the quality and safety of food during storage through a novel aspect.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Zhenying Hu, Jingjing Duan
Summary: This review explores the presence of 1-deoxySLs and their analogs in the diet, as well as their potential physiological and pathophysiological aspects. It highlights the mysteries and research gaps surrounding 1-deoxySLs as dietary and endogenously produced components.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2022)