Article
Pharmacology & Pharmacy
Betul Rabia Erdogan, Zeynep Elif Yesilyurt, Ebru Arioglu-Inan, Martin Christian Michel
Summary: The study showed that fenoterol is a suitable tool to evaluate beta(2)-AR-mediated relaxation responses in the rat urinary bladder and other smooth muscle preparations containing multiple subtypes of beta-AR.
Article
Chemistry, Multidisciplinary
Huimin Zhu, Wanbo Zeng, Tangna Zhao, Weiguo Shi, Xiao Dong, Aiping Zhang, Xiang Li, Liang Xu
Summary: This study synthesized six derivatives of AICAR and evaluated their anti-fatigue effects. The optimal compound ZHM-01 exhibited significant anti-fatigue effects in animal models, while also demonstrating good biological safety.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Byeong Moo Kim, Dae Hyun Kim, Yeo Jin Park, Sugyeong Ha, Yeon Ja Choi, Hak Sun Yu, Ki Wung Chung, Hae Young Chung
Summary: PAR2 plays a regulatory role in autophagy during HFD-induced hepatic steatosis, and its deficiency protects male mice from the effects of HFD-induced hepatic steatosis, which is associated with AMPK activation and autophagy levels.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Oncology
Ariadna Brito, Candice Merle, Pauline Lagarde, Benjamin Faustin, Anne Devin, Lydia Lartigue, Frederic Chibon
Summary: The study found that cell-to-cell fusion hybrids have a strong metabolic activity, relying on enhanced glycolysis for proliferation, while the drug AICAR can effectively inhibit their growth and invasive capacity by modulating the metabolic equilibrium, suggesting a potential novel therapeutic strategy for cancer treatment.
Article
Immunology
Shih-Hsiu Chou, Tsai-Wen Wan, Chung-Wai Shiau, Ling -Han Chen, Hsueh-Chun Lin, Hao-Chieh Chiu
Summary: In this study, it was found that the tyrosine kinase inhibitor nilotinib has antibacterial activity against intracellular Salmonella enterica. The aim was to exploit the antibacterial activity of nilotinib and understand its mechanism of action.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Biochemistry & Molecular Biology
Ram Hari Pokhrel, Suman Acharya, Jae-Hee Ahn, Ye Gu, Mahesh Pandit, Jong-Oh Kim, Yun-Yong Park, Ben Kang, Hyun-Jeong Ko, Jae-Hoon Chang
Summary: In this study, it was found that AMP-activated protein kinase (AMPK) plays a regulatory role in the expression of PD-1 through the HMGCR/p38 MAPK/GSK3 beta signaling pathway in regulatory T cells (Tregs). This suggests that AMPK activators may have synergistic antitumor effects in murine tumor models when combined with other treatments.
Article
Cell Biology
Jordan T. Bateman, Erica S. Levitt
Summary: G protein-biased opioid agonists are proposed as safer analgesics with less respiratory depression. Studies have linked respiratory depression to G protein bias and intrinsic efficacy, refuting the role of beta-arrestin signaling in opioid-induced respiratory depression.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Shan Zhou, Qinyu Wu, Xu Lin, Xian Ling, Jinhua Miao, Xi Liu, Chengxiao Hu, Yunfang Zhang, Nan Jia, Fan Fan Hou, Youhua Liu, Lili Zhou
Summary: The upregulation of CB2 in renal tubular epithelial cells is closely correlated with the progression of kidney fibrosis and is associated with the activation of beta-catenin. CB2 induces the formation of a beta-arrestin 1/Src/beta-catenin complex, leading to fibrotic injury, while its inhibition or knockdown can prevent this process. The CB2/beta-catenin pathway creates a positive feedback loop that plays a key role in the pathogenesis of kidney fibrosis.
KIDNEY INTERNATIONAL
(2021)
Article
Cell Biology
Yuju Kim, Yunna Lee, Gwangbeom Heo, Sihyun Jeong, Soyeong Park, Jin-Wook Yoo, Yunjin Jung, Eunok Im
Summary: The study found that PAR2-induced autophagy can maintain mucosal barrier integrity by regulating intestinal epithelial permeability, possibly through the β-arrestin-ERK1/2 pathway. Therefore, regulating PAR2 can be a suitable strategy for treating intestinal diseases.
Article
Pharmacology & Pharmacy
Omar Hamed, Radhika Joshi, Mahmoud M. Mostafa, Mark A. Giembycz
Summary: This study found that the effects of formoterol on inflammatory gene expression in airway epithelia are mediated by PKA and involve the cooperation of PKA-Cα and PKA-Cβ.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Berna Guven, Arzu Onay-Besikci
Summary: This review focuses on the role of beta arrestins in mediating metabolic modulation, particularly in relation to insulin signaling. It is suggested that beta arrestins play a regulatory role in insulin secretion and action, making them potential targets for therapeutic intervention in metabolic disorders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marta Sanchez-Soto, Noelia M. Boldizsar, Kayla A. Schardien, Nora S. Madaras, Blair K. A. Willette, Laura R. Inbody, Christopher Dasaro, Amy E. Moritz, Julia Drube, Raphael S. Haider, R. Benjamin Free, Carsten Hoffman, David R. Sibley
Summary: The recruitment and activation of beta-arrestins to the D2 dopamine receptor (D2R) are not completely dependent on GPCR kinase (GRK)-mediated receptor phosphorylation, highlighting the importance of the GRK subfamily in D2R-beta-arrestin interactions.
Article
Biochemistry & Molecular Biology
Haohong Zhan, Qiang Zhang, Chenyu Zhang, Jingge Cheng, Yilin Yang, Cong Liu, Shuhao Li, Chuyue Wang, Junqin Yang, Hanmei Ge, Dawang Zhou, Bo Li, Hongyan Wei, Chunlin Hu
Summary: This study investigated the protective mechanism of AMPK activation on brain injury secondary to cardiac arrest. The results showed that AMPK improved memory function, reduced neuronal cell injury and apoptosis after resuscitation. Further research found that AMPK activated HNF4a to target Bcl-2 and inhibit apoptosis.
NEUROCHEMICAL RESEARCH
(2023)
Article
Oncology
Caitrin Crudden, Takashi Shibano, Dawei Song, Mihnea P. Dragomir, Sonia Cismas, Julianna Serly, Daniela Nedelcu, Enrique Fuentes-Mattei, Andrei Tica, George A. Calin, Ada Girnita, Leonard Girnita
Summary: This study elucidates the molecular and biological roles of biased signaling downstream RTK, providing a novel approach to enhance the efficacy of anti-IGF1R-targeted therapy in cancer by targeting system bias. The findings suggest a promising strategy for the rational design or repurposing of therapeutics to selectively cross-target the IGF1R or other RTK.
Article
Multidisciplinary Sciences
Donghwa Kim, Alina Tokmakova, Lauren K. Lujan, Hannah R. Strzelinski, Nicholas Kim, Maliheh Najari Beidokhti, Marc A. Giulianotti, Amirhossein Mafi, Jung-A A. Woo, Steven S. An, William A. Goddard, Stephen B. Liggett
Summary: The study identified a potentially beneficial β(2)-adrenergic receptor agonist, C1-S, for treating asthma, which diverges from the influence of β-arrestin by retaining Gas signaling, resulting in biologically relevant biasing effects.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)