SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells

The Platelet Lifeline to Cancer: Challenges and Opportunities

(2018) Monika Haemmerle et al.   CANCER CELL

CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought

(2018) Mary E. Klein et al.   CANCER CELL

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

SerpinB2 deficiency in mice reduces bleeding times via dysregulated platelet activation

(2018) Wayne A Schroder et al.   PLATELETS

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Platelets as a novel source of Gremlin-1: Implications for thromboinflammation

(2017) Madhumita Chatterjee et al.   THROMBOSIS AND HAEMOSTASIS

The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis

(2017) Claudio A. Valenzuela et al.   Frontiers in Oncology

The role of platelets in the tumor microenvironment: From solid tumors to leukemia

(2016) MengJie Yan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Role of platelets in cancer and cancer-associated thrombosis: Experimental and clinical evidences

(2016) Soraya Mezouar et al.   THROMBOSIS RESEARCH

Cellular senescence controls fibrosis in wound healing

(2016) Joon-Il Jun et al.   Aging-US

Fibronectin orchestrates thrombosis and hemostasis

(2015) Yiming Wang et al.   Oncotarget

Breaking the Mold: Transcription Factors in the Anucleate Platelet and Platelet-Derived Microparticles

(2015) Katie L. Lannan et al.   Frontiers in Immunology

Presence of intratumoral platelets is associated with tumor vessel structure and metastasis

(2014) Rong Li et al.   BMC CANCER

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Platelets guide the formation of early metastatic niches

(2014) M. Labelle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Lipopolysaccharide Stimulates Platelets through an IL-1  Autocrine Loop

(2013) G. T. Brown et al.   JOURNAL OF IMMUNOLOGY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Stat3 Contributes to Indoxyl Sulfate-Induced Inflammatory and Fibrotic Gene Expression and Cellular Senescence

(2012) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Paraneoplastic Thrombocytosis in Ovarian Cancer

(2012) Rebecca L. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling

(2012) S. Rajagopalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis

(2011) E. M. Battinelli et al.   BLOOD

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells

(2011) C Canino et al.   ONCOGENE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

(2010) K. Michaud et al.   CANCER RESEARCH

New biomarkers probing depth of cell senescence assessed by laser scanning cytometry

(2010) Hong Zhao et al.   CYTOMETRY PART A

Induction of senescence markers after neo-adjuvant chemotherapy of malignant pleural mesothelioma and association with clinical outcome: An exploratory analysis

(2010) Roy Sidi et al.   EUROPEAN JOURNAL OF CANCER

Thrombin stimulates melanoma tumor-cell binding to endothelial cells and subendothelial matrix

(2010) A. Klepfish et al.   INTERNATIONAL JOURNAL OF CANCER

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence

(2009) Peter D. Adams   MOLECULAR CELL

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Vitronectin inhibits plasminogen activator inhibitor-1-induced signalling and chemotaxis by blocking plasminogen activator inhibitor-1 binding to the low-density lipoprotein receptor-related protein

(2008) Yuichi Kamikubo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY