Article
Medicine, Research & Experimental
Megha Srinivas, Preeti Sharma, Siddharth Jhunjhunwala
Summary: Research findings suggest that immune cells can phagocytose particles under constant fluidic flow. Different cell types show similar or better uptake rates under flow conditions. Even in the presence of crowded red blood cells, neutrophils and monocytes are able to uptake particles while flowing.
MOLECULAR PHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Tala Shekarian, Carl P. Zinner, Ewelina M. Bartoszek, Wandrille Duchemin, Anna T. Wachnowicz, Sabrina Hogan, Manina M. Etter, Julia Flammer, Chiara Paganetti, Tomas A. Martins, Philip Schmassmann, Steven Zanganeh, Francois Le Goff, Manuele G. Muraro, Marie-Francoise Ritz, Darci Phillips, Salil S. Bhate, Graham L. Barlow, Garry P. Nolan, Christian M. Schuerch, Gregor Hutter
Summary: This study demonstrated that ex vivo immunotherapy of GBM explants can induce an active antitumoral immune response within the tumor center, providing a framework for multidimensional personalized assessment of tumor response to immunotherapy.
Article
Multidisciplinary Sciences
Luciane Costa Dalboni, Anuska Marcelino Alvares Saraiva, Fabiana Toshie de Camargo Konno, Elizabeth Cristina Perez, Jessica Feliciana Codeceira, Diva Denelle Spadacci-Morena, Maria Anete Lallo
Summary: This study found that pre-incubation of macrophages with apoptotic cells and subsequent challenge with Encephalitozoon cuniculi microsporidia increased phagocytosis and promoted pathogen multiplication. Additionally, efferocytosis of apoptotic cells and pathogen challenge decreased macrophage viability and led to the polarization of macrophages to an M2 profile, facilitating pathogen development.
Article
Immunology
Stefan Muenster, Valentina Zschernack, Birte Dierig, Stilla Frede, Georg Baumgarten, Mark Coburn, Christian Putensen, Christina Katharina Weisheit
Summary: The antibiotics vancomycin and daptomycin have immunomodulatory effects on cells involved in innate immunity in a murine model of LPS-induced sepsis. Further studies are needed to evaluate whether these antibiotics exhibit synergistic effects in the treatment of septic patients, beyond their bactericidal properties.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
N. Fine, J. W. Chadwick, C. Sun, K. K. Parbhakar, N. Khoury, A. Barbour, M. Goldberg, H. C. Tenenbaum, M. Glogauer
Summary: The presence of periodontal diseases is closely related to other chronic inflammatory conditions such as cardiovascular disease, diabetes, and arthritis. Studies show that periodontal tissue inflammation affects the production and activation of polymorphonuclear neutrophils (PMNs), contributing to a hyperinflammatory response in the body. This systemic effect of PD on immune response can exacerbate inflammatory reactions when faced with secondary infections, highlighting the complex interactions between PD and other inflammatory diseases.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Veterinary Sciences
Miguel Criado, Valentin Perez, Noive Arteche-Villasol, Natalia Elguezabal, Elena Molina, Julio Benavides, Daniel Gutierrez-Exposito
Summary: Neutrophils are important components of the innate immune response, capable of killing bacteria through various mechanisms. This study investigated the response of caprine neutrophils to Mycobacterium avium subspecies paratuberculosis (Map) infection, and found that they displayed a strong innate immune response against the pathogen. These findings provide a foundation for further research on the role of neutrophils in paratuberculosis.
VETERINARY RESEARCH
(2023)
Article
Immunology
Simon Lea, Rosemary Gaskell, Simon Hall, Barbara Maschera, Edith Hessel, Dave Singh
Summary: In COPD patients, sputum neutrophils showed higher phagocytic activity towards Streptococcus pneumoniae compared to macrophages, while uptake of non-typeable Haemophilus influenzae was mainly by neutrophils. Exposure to NTHi led to reduced expression of CD206 and CD14 on macrophages and CD16 on neutrophils.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Jamal Hussen, Mayyadah Abdullah Alkuwayti, Baraa Falemban, Sameer M. Alhojaily, Salma Al Adwani, El Awad El Hassan, Abdullah I. A. Al-Mubarak
Summary: This study investigated the impact of TLR ligands on the phenotype and function of camel blood neutrophils. Different TLR ligands showed specific modulatory effects on cell size, phagocytosis activity, ROS production, and cell surface antigen expression in camel neutrophils.
VETERINARY SCIENCES
(2023)
Article
Immunology
Ioannis Mitroulis, Akrivi Chrysanthopoulou, Georgios Divolis, Charalampos Ioannidis, Maria Ntinopoulou, Athanasios Tasis, Theocharis Konstantinidis, Christina Antoniadou, Natalia Soteriou, George Lallas, Stella Mitka, Mathias Lesche, Andreas Dahl, Stephanie Gembardt, Maria Panopoulou, Paschalis Sideras, Ben Wielockx, Uenal Coskun, Konstantinos Ritis, Panagiotis Skendros
Summary: This study provides an in-depth analysis of the transcriptomic alterations that occur in human phagocytes upon infection and in peripheral blood immune populations during active brucellosis. It reveals molecular changes related to the disease progression and treatment response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Fabiana Albani Zambuzi, Priscilla Mariane Cardoso-Silva, Ricardo Cardoso Castro, Caroline Fontanari, Flavio da Silva Emery, Fabiani Gai Frantz
Summary: Decitabine treatment enhances bacterial phagocytosis and IL-8 release in monocytes, but impairs their microbicidal activity. It also promotes M2-like profile during monocyte-to-macrophage differentiation. In addition, decitabine reduces inflammatory cytokine release during macrophage-lymphocyte co-culture, indicating a potential therapeutic role in immune response modulation.
Article
Engineering, Biomedical
Derek Avery, Lais Morandini, Natalie Celt, Leah Bergey, Jamelle Simmons, Rebecca K. Martin, Henry J. Donahue, Rene Olivares-Navarrete
Summary: This study evaluates the response of inflammatory and immune cells to four common orthopedic materials (pure titanium, titanium alloy, 316L stainless steel, PEEK). The results show that PEEK and stainless steel induce a stronger inflammatory response compared to titanium or titanium alloy, characterized by high infiltration of neutrophils and T cells. The chemical composition of the biomaterials plays a crucial role in the immune cell response.
ACTA BIOMATERIALIA
(2023)
Review
Immunology
Cheldon Ann Alcantara, Ira Glassman, Kevin H. Nguyen, Arpitha Parthasarathy, Vishwanath Venketaraman
Summary: Mycobacterium tuberculosis (M. tb) remains a major cause of death in developing countries. The BCG vaccine is widely used in developing countries but its efficacy is still uncertain. Neutrophils play a crucial role in the immune response against M. tb, promoting clearance of the bacteria and regulating the inflammatory response. This review highlights the role of neutrophils during M. tb infection and emphasizes the need for more research on effective vaccination.
Article
Immunology
Bohdana Kokhanyuk, Kornelia Bodo, Gyoergy Setalo, Peter Nemeth, Peter Engelmann
Summary: This study compared the engulfment mechanisms of human monocytic cells, macrophage-like cells, and earthworm coelomocytes towards bacteria, revealing the conserved role of actin-dependent phagocytosis in different cell types. Actin depolymerization strongly inhibited bacterial engulfment, leading to decreased colocalization of lysosomes with bacteria. Inhibition of actin depolymerization had differential effects on immune receptor-related molecule expression in different cell types. Insights into the evolution of phagocytes in eukaryotes were gained through the similarities in bacterial internalization mechanisms between earthworm and human phagocytes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Yung-Che Chen, Chang -Chun Hsiao, Chao-Chien Wu, Tung-Ying Chao, Sum-Yee Leung, Yu -Ping Chang, Chia-Cheng Tseng, Chiu-Ping Lee, Po-Yuan Hsu, Ting-Ya Wang, Po-Wen Wang, Ting-Wen Chen, Meng-Chih Lin
Summary: This study explores a new approach for treating active tuberculosis (TB) by screening and validating microRNAs with immune-regulatory functions. The research identified differentially expressed microRNAs associated with TB and revealed their roles in regulating autophagy, apoptosis, and macrophage phagocytosis. The findings provide evidence for microRNA-based host-directed immunotherapy and offer new therapeutic targets for treatment-refractory TB.
JOURNAL OF INFECTION
(2022)
Review
Immunology
Bart J. M. Grijmans, Sander B. van der Kooij, Monica Varela, Annemarie H. Meijer
Summary: Cells of the innate immune system use phagocytosis and autophagy mechanisms to neutralize microbial threats. LC3-associated phagocytosis (LAP) plays a crucial role in this process and interacts with bacterial pathogens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Alyssa C. Vecchio, Christina M. Marra, Jeffrey Schouten, Hongyu Jiang, Johnstone Kumwenda, Khuanchai Supparatpinyo, James Hakim, Ned Sacktor, Thomas B. Campbell, Srikanth Tripathy, Nagalingeswaran Kumarasamy, Alberto La Rosa, Breno Santos, Marcus T. Silva, Cecilia Kanyama, Cindy Firnhaber, Mina C. Hosseinipour, Rosie Mngqibisa, Colin Hall, Paola Cinque, Kevin Robertson
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Multidisciplinary Sciences
Manickam Ashokkumar, Aanand Sonawane, Maike Sperk, Srikanth P. Tripathy, Ujjwal Neogi, Luke Elizabeth Hanna
SCIENTIFIC REPORTS
(2020)
Article
Infectious Diseases
Divya Anthwal, Rakesh Kumar Gupta, Narayan Sivaramakrishnan Gomathi, Srikanth Prasad Tripathy, Dasarathi Das, Sanghamitra Pati, Nikita Panwalkar, Prabha Desikan, Kiran Bala, Urvashi B. Singh, Manpreet Bhalla, Ritu Singhal, Ajoy Kumar Verma, Khalid Umar Khayyam, Vithal Prasad Myneedu, Rohit Sarin, Sandeep Sharma, Avi Kumar Bansal, Umesh D. Gupta, Sripad A. Patil, Abhinav Goyal, Ashawant Gupta, Manjula Singh, Nalini Kant Gupta, Sagarika Haldar, Jaya Sivaswami Tyagi
Summary: The study evaluated the performance of the 'TBDetect' kit-based bio-safe fluorescent microscopy filter in comparison to direct smear microscopy and culture for the detection of pulmonary tuberculosis in India. TBDetect showed a higher positivity rate compared to other methods, with efficient sputum concentration and disinfection confirmed through a six-site validation study. Scientists and technicians praised the ease of use and convenience of TBDetect microscopy during the study.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Multidisciplinary Sciences
Banurekha Velayutham, Lavanya Jayabal, Basilea Watson, Saraswathy Jagadeesan, Dhanalakshmi Angamuthu, Priscilla Rebecca, Bella Devaleenal, Dina Nair, Srikanth Tripathy, Sriram Selvaraju
Article
Infectious Diseases
Shanmugam Sivakumar, Yuvaraj Chandramohan, Gokul Raj Kathamuthu, Gomathi Sekar, Devika Kandhasamy, Venkatesan Padmanaban, Syed Hissar, Srikanth P. Tripathy, Ramalingam Bethunaickan, Baskaran Dhanaraj, Subash Babu, Uma Devi Ranganathan
BMC INFECTIOUS DISEASES
(2020)
Article
Infectious Diseases
Sushanta Kumar Barik, Keshar Kunja Mohanty, Ashok Kumar Mohanty, Preeti Rawat, G. Gopal, Deepa Bisht, Shripad A. Patil, Rananjay Singh, Devesh Sharma, Srikanth Prasad Tripathy, Rekha Tandon, Tej Pal Singh, Srikanta Jena
BMC INFECTIOUS DISEASES
(2020)
Article
Multidisciplinary Sciences
Pasupathy Saravanan, V. N. Azger Dusthackeer, R. S. Rajmani, B. Mahizhaveni, Christy R. Nirmal, Sam Ebenezer Rajadas, Neerupma Bhardwaj, C. Ponnuraja, Adhin Bhaskar, A. K. Hemanthkumar, Geetha Ramachandran, Srikanth P. Tripathy
Summary: The study synthesized a novel compound Rifaphenazine (RPZ) with potent anti-TB activity, which showed inhibitory effects on Mtb at low concentrations and demonstrated efficient bactericidal capabilities. Furthermore, RPZ exhibited non-cytotoxicity on human monocytic cells, indicating its potential as a new anti-TB drug candidate.
SCIENTIFIC REPORTS
(2021)
Letter
Infectious Diseases
Pragya D. Yadav, Rima R. Sahay, Sachee Agrawal, Anita Shete, Balkrishna Adsul, Srikanth Tripathy, Dimpal A. Nyayanit, Manish Manrai, Deepak Y. Patil, Sanjay Kumar, Vikas Marwah, Gajanan N. Sapkal, Jayanthi Shastri, Rajlakshmi Viswanathan, Priyanka Pandit, Yogendra Mishra, Smita Chavan, Yash Joshi, T. Ajai Kumar, Triparna Majumdar, Abhinendra Kumar, Savita Patil, Renuka Munshi, Unnati Desai, Himanshu Kaushal, Annasaheb Suryawanshi, Manisha Dudhmal, Pranita Gawande, Rajlaxmi Jain, Ashwini Waghmare, Kaumudi Kalele, Pratiksha Vedpathak, Jyoti Yemul, Poonam Bodke, Tejashri Kore, A. L. Kakrani, Prachi Athavale, Poonam Suryawanshi, Sudhir Patsute, Vikram Padbidri, Pradip Awate, Priya Abraham
JOURNAL OF INFECTION
(2022)
Article
Immunology
N. S. Gomathi, Manjula Singh, Urvashi B. Singh, V. P. Myneedu, D. S. Chauhan, Rohit Sarin, Anant Mohan, Anuj Bhatnagar, Jiten Singh Khangembam, T. Kannan, M. V. V. Rao, Jyoti Logani, Bindu Dey, Raman R. Gangakhedkar, Soumya Swaminathan, Srikanth Tripathy
INDIAN JOURNAL OF MEDICAL RESEARCH
(2020)
Article
Genetics & Heredity
Murugesan Harishankar, Pavithra Sampath, Veerasamy Athikesavan, Ponnuraja Chinnaiyan, Banurekha Velayutham, Uday Kumar Putcha, Srikanth Prasad Tripathy, Uma Devi Ranganathan, Paramasivam Selvaraj, Ramalingam Bethunaickan
Review
Biochemistry & Molecular Biology
Krisna Moorthi Periyasamy, Uma Devi Ranganathan, Srikanth Prasad Tripathy, Ramalingam Bethunaickan
MOLECULAR IMMUNOLOGY
(2020)
Article
Microbiology
S. Siva Kumar, S. Ashok Kumar, Gomathi Sekar, K. Devika, M. Bhasker, S. Sriram, C. K. Dolla, Pradeep Aravindan Menon, Srikanth Prasad Tripathy, P. R. Narayanan, Uma Devi Ranganathan, Sujatha Narayanan, Rajesh Mondal
INTERNATIONAL JOURNAL OF MICROBIOLOGY
(2020)
Article
Microbiology
Balaji Subramanyam, Gomathi Sivaramakrishnan, Devi Sangamithrai, Rajkumar Ravi, Kannan Thiruvengadam, Vaishnavi Vijayaragavan, Ayswarya Selvaraju, Srikanth Prasad Tripathy, Rajesh Mondal
INTERNATIONAL JOURNAL OF MICROBIOLOGY
(2020)
Article
Immunology
Manoj V. Murhekar, Tarnm Bhatnagar, Sriram Selvaraju, Kiran Radeo, V. Saravanakumar, Jeromie Wesley Vivian Thangaraj, Muthusamy Santhosh Kumar, Naman Shah, R. Sabarinathan, Alka Turuk, Parveen Kumar Anand, Smita Asthana, Rakesh Balachandar, Sampada Dipak Bangar, Avi Kumar Bansal, Jyothi Bhat, Debjit Chakraborty, Chethana Rangaraju, Vishal Chopra, Dasarathi Das, Alok Kumar Deb, Kangjam Rekha Devi, Gaurav Raj Dwivedi, S. Muhammad Salim Khan, Inaamul Haq, M. Sunil Kumar, Avula Laxmaiah, Major Madhukar, Amarendra Mahapatra, Anindya Mitra, A. R. Nirmala, Avinash Pagdhune, Mariya Amin Qurieshi, Tekumalla Ramarao, Seema Sahay, Y. K. Sharma, Marinaik Basavegowdanadoddi Shrinivasa, Vijay Kumar Shukla, Prashant Kumar Singh, Ankit Viramgami, Vimith Cheruvathoor Wilson, Rajiv Yadav, C. P. Girish Kumar, Hanna Elizabeth Luke, Uma Devi Ranganathan, Subash Babu, Krithikaa Sekar, Pragya D. Yadav, Gajanan N. Sapkal, Aparup Das, Pradeep Das, Shanta Dutta, Rajkumar Hemalatha, Ashwani Kumar, Kanwar Narain, Somashekar Narasimhaiah, Samiran Panda, Sanghamitra Pati, Shripad Patil, Kamalesh Sarkar, Shalini Singh, Rajni Kant, Srikanth Tripathy, G. S. Toteja, Ginidhara R. Babu, Shashi Kant, J. P. Muhyil, Ravindra Mohan Pandey, Swarup Sarkar, Sujeet K. Singh, Sanjay Zodpey, Raman R. Gangakhedkar, D. C. S. Reddy, Balram Bhargava
INDIAN JOURNAL OF MEDICAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Binbin Chang, Zhang Wang, Hui Cheng, Tingyuan Xu, Jieyu Chen, Wan Wu, Yizhi Li, Yong Zhang
Summary: Acacetin can attenuate sepsis-induced ALI by inhibiting the inflammatory response and promoting macrophage polarization. This study is of great significance for the development of new treatments for sepsis-induced ALI.
Review
Biochemistry & Molecular Biology
Nikoleta Bizymi, Andreas M. Matthaiou, Irene Mavroudi, Aristea Batsali, Helen A. Papadaki
Summary: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that have immunomodulatory properties. They interact extensively with other innate or adaptive immune cells and can either enhance or attenuate immune responses depending on the triggering conditions. However, their positive role in host defense mechanisms is rarely discussed in the literature.