Article
Genetics & Heredity
Leslie Hotchkiss Hayes, Morgane Perdomini, Asli Aykanat, Casie A. Genetti, Heather L. Paterson, Belinda S. Cowling, Christian Freitag, Alan H. Beggs
Summary: This study provides a detailed characterization of DNM2-related CNM, a rare neuromuscular disease, revealing its predominantly early-onset myopathy resulting in difficulty with ambulation and occasionally bulbar and respiratory dysfunction. The findings from this study are important for clinical trial readiness in future disease-modifying therapies.
NEUROLOGY-GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Julie De Oliveira, Edith Chadili, Cyril Turies, Francois Brion, Xavier Cousin, Nathalie Hinfray
Summary: Transgenic zebrafish models are commonly used to study the effects of endocrine disrupting chemicals, with this study evaluating different transgenic and mutant zebrafish strains for EDC testing. Results showed that the transgene insertion and mutations did not significantly affect the measured endpoints in basal conditions, indicating the potential use of these models for EDC testing. The next step will be to determine the sensitivity of these models to chemical exposure for further validation in fish assays.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Pengcheng Han, Chao Su, Yanfang Zhang, Chongzhi Bai, Anqi Zheng, Chengpeng Qiao, Qing Wang, Sheng Niu, Qian Chen, Yuqin Zhang, Weiwei Li, Hanyi Liao, Jing Li, Zengyuan Zhang, Heecheol Cho, Mengsu Yang, Xiaoyu Rong, Yu Hu, Niu Huang, Jinghua Yan, Qihui Wang, Xin Zhao, George Fu Gao, Jianxun Qi
Summary: Multiple SARS-CoV-2 variants, including Alpha, Beta, and Gamma, were studied in terms of their interactions with the human ACE2 receptor. The study identified key residues in the receptor-binding domain that affect binding affinity and demonstrated the potential of soluble ACE2 protein in preventing viral entry. The findings could contribute to the development of novel therapeutic and prophylactic agents targeting these emerging mutants.
NATURE COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Siddhartha P. Kar, Pedro M. Quiros, Muxin Gu, Tao Jiang, Jonathan Mitchell, Ryan Langdon, Vivek Iyer, Clea Barcena, M. S. Vijayabaskar, Margarete A. Fabre, Paul Carter, Slave Petrovski, Stephen Burgess, George S. Vassiliou
Summary: This study analyzes genetic data to understand the genetic predisposition and causal links of clonal hematopoiesis (CH) in a large population. It identifies new genetic loci associated with CH, subtype-specific associations, and causal relationships between CH and other traits.
Article
Environmental Sciences
Marco Tarasco, Paulo J. Gavaia, Anabela Bensimon-Brito, Joao Cardeira-da-Silva, Srinath Ramkumar, Fabrice P. Cordelieres, Stefan Guenther, Maria J. Bebianno, Didier Y. R. Stainier, M. Leonor Cancela, Vincent Laize
Summary: Persistent and ubiquitous organic pollutants, like BaP, pose a major threat to aquatic organisms and human health, with adverse effects on fish bone formation and skeletal development. BaP induces activation of xenobiotic and metabolic pathways, impacting extracellular matrix formation, and regulating inflammation markers in larvae. BaP exposure negatively affects bone remodeling and may involve a role for neutrophils in inflammatory bone reduction.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Emmanuel Marquez-Legorreta, Lena Constantin, Marielle Piber, Itia A. Favre-Bulle, Michael A. Taylor, Ann S. Blevins, Jean Giacomotto, Dani S. Bassett, Gilles C. Vanwalleghem, Ethan K. Scott
Summary: Habituation is altered in fmr1 mutants, leading to slower behavioral habituation in zebrafish. Different functional categories of neurons are located in characteristic locations throughout the brain, and their functional properties and resulting behavior can be modulated by stimulus saliency and timing.
NATURE COMMUNICATIONS
(2022)
Article
Physiology
Maki Kamoshita, Rechal Kumar, Marco Anteghini, Markus Kunze, Markus Islinger, Vitor Martins dos Santos, Michael Schrader
Summary: This study provides the first comprehensive inventory of Danio rerio peroxisomal proteins and compares them systematically with those of human peroxisomes. The findings reveal the absence of two well-known mammalian peroxisomal proteins in zebrafish, but the presence of a putative peroxisomal protein and other differences. Additionally, novel candidate peroxisomal proteins in zebrafish are identified.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
M. Frank Erasmus, Fortunato Ferrara, Sara D'Angelo, Laura Spector, Camila Leal-Lopes, Andre A. Teixeira, Jesper Sorensen, Suhani Nagpal, Kathryn Perea-Schmittle, Alok Choudhary, William Honnen, David Calianese, Luis Antonio Rodriguez Carnero, Simon Cocklin, Victor Greiff, Abraham Pinter, Andrew R. M. Bradbury
Summary: This study establishes NGS guidelines for therapeutic antibody discovery, demonstrating the advantages of NGS in expanding unique HCDR3 clusters, increasing high affinity antibodies, and improving lead prioritization. The study also reveals a lack of association between CDR frequencies derived from NGS and affinity.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Paula Silva, Maria Rodriguez-Perez, Emma Burgos-Ramos
Summary: This review explores the potential of a zebrafish model in investigating the antioxidant effects of olive oil and wine, which are key components of the Mediterranean diet, in preventing age-related diseases, particularly cardiovascular conditions. The review highlights the genetic proximity of zebrafish to humans, offering a unique opportunity for translational insights into the health benefits of olive oil and wine.
Review
Polymer Science
Ruth Naomi, Pauzi Muhd Ridzuan, Hasnah Bahari
Summary: The review discusses the unique high biocompatibility of Collagen type I (Col-I) in human tissue and its widespread applications in various fields. It covers the structure, sources, synthesis, extraction methods, characteristics, applications, and biomarkers of Col-I, providing specific information on its availability over the past five years for researchers interested in collagen-based products for therapeutic purposes.
Review
Cell Biology
Sarah A. Neely, David A. Lyons
Summary: Glia are a diverse collection of cells that play essential roles in the nervous system. Recent advances in animal models, particularly using zebrafish, have provided important insights into the function and interactions of glial cells, contributing to our understanding of their complex roles in development and throughout life.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Curtis R. French
Summary: Axenfeld-Rieger syndrome (ARS) is a group of developmental disorders affecting the anterior segment of the eye and systemic developmental defects in some patients. Nearly half of known cases are caused by genetic mutations in the FOXC1 and PITX2 genes, while the genetic lesions in the remaining cases remain unresolved. Zebrafish models have been created to study how mutations in these transcription factors lead to a wide array of developmental phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Sandeep Xxxx, Mir Hilal Ahmad, Linchi Rani, Amal Chandra Mondal
Summary: This review summarizes the common shared pathophysiological mechanisms, including insulin resistance, inflammation, mitochondrial dysfunction, endoplasmic reticulum stress, autophagy, and the ubiquitin-proteasome system, that independently mediate the onset and etiopathogenesis of type 2 diabetes mellitus and Parkinson's disease. Understanding these common molecular pathways may provide alternative treatment strategies for both diseases.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
Almke Bader, Jincheng Gao, Thibaud Riviere, Bettina Schmid, Barbara Walzog, Daniela Maier-Begandt
Summary: Neutrophils, key players in innate immunity, are released from the bone marrow of adult mammals and recruited to sites of inflammation from peripheral blood. A study using zebrafish models with a genetic deletion of CD18, a subunit of beta(2) integrins, demonstrated similarities in amino acid sequences between zebrafish and human CD18. The findings showed the functional importance of CD18 for neutrophil trafficking in zebrafish larvae, shedding new light on neutrophil biology in vertebrates and offering a new model for studying LAD type I.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fabiana Mallone, Ludovico Alisi, Luca Lucchino, Valerio Di Martino, Marcella Nebbioso, Marta Armentano, Alessandro Lambiase, Antonietta Moramarco
Summary: Neurofibromatosis type 1 (NF1) is a rare genetic disorder that affects the skin, nervous system, and eyes. Ocular diagnostic hallmarks of NF1 include various abnormalities in the eyes such as nodules, neurofibromas, and spots. Recent advancements in imaging techniques have allowed for better characterization of these eye abnormalities in NF1 patients. This paper reviews the latest progress in understanding and diagnosing choroidal and retinal abnormalities in NF1 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Tamar E. Sztal, Mo Zhao, Caitlin Williams, Viola Oorschot, Adam C. Parslow, Aminah Giousoh, Michaela Yuen, Thomas E. Hall, Adam Costin, Georg Ramm, Phillip I. Bird, Elisabeth M. Busch-Nentwich, Derek L. Stemple, Peter D. Currie, Sandra T. Cooper, Nigel G. Laing, Kristen J. Nowak, Robert J. Bryson-Richardson
ACTA NEUROPATHOLOGICA
(2015)
Article
Biochemistry & Molecular Biology
Jiayu Wen, Hong Duan, Fernando Bejarano, Katsutomo Okamura, Lacramioara Fabian, Julie A. Brill, Diane Bortolamiol-Becet, Raquel Martin, J. Graham Ruby, Eric C. Lai
Article
Genetics & Heredity
Maria Grazia Giansanti, Timothy E. Vanderleest, Cayla E. Jewett, Stefano Sechi, Anna Frappaolo, Lacramioara Fabian, Carmen C. Robinett, Julie A. Brill, Dinah Loerke, Margaret T. Fuller, J. Todd Blankenship
Review
Cell Biology
Julie A. Brill, Sukriye Yildirim, Lacramioara Fabian
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2016)
Article
Plant Sciences
Melissa Bredow, Heather E. Tomalty, Lindsay Smith, Virginia K. Walker
PLANT CELL AND ENVIRONMENT
(2018)
Review
Oncology
J. Javier Hernandez, Michael Pryszlak, Lindsay Smith, Connor Yanchus, Naheed Kurji, Vijay M. Shahani, Steven V. Molinski
FRONTIERS IN ONCOLOGY
(2017)
Article
Cell Biology
Alind Gupta, Lacramioara Fabian, Julie A. Brill
JOURNAL OF CELL SCIENCE
(2018)
Review
Cell Biology
Jonathan R. Volpatti, Almundher Al-Maawali, Lindsay Smith, Ageela Al-Hashim, Julie A. Brill, James J. Dowling
DISEASE MODELS & MECHANISMS
(2019)
Review
Neurosciences
Lacramioara Fabian, James J. Dowling
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Lindsay Smith, Lacramioara Fabian, Almundher Al-Maawali, Ramil R. Noche, James J. Dowling
Article
Multidisciplinary Sciences
Yonit Tsatskis, Robyn Rosenfeld, Joel D. Pearson, Curtis Boswell, Yi Qu, Kyunga Kim, Lacramioara Fabian, Ariz Mohammad, Xian Wang, Michael Robson, Karen Krchma, Jun Wu, Joao Goncalves, Didier Hodzic, Shu Wu, Daniel Potter, Laurence Pelletier, Wade H. Dunham, Anne-Claude Gingras, Yu Sun, Jin Meng, Dorothea Godt, Tim Schedl, Brian Ciruna, Kyunghee Choi, John R. B. Perry, Rod Bremner, Eric C. Schirmer, Julie A. Brill, Andrea Jurisicova, Helen McNeill
Article
Cell Biology
Karla G. Espinosa, Salma Geissah, Linda Groom, Jonathan Volpatti, Ian C. Scott, Robert T. Dirksen, Mo Zhao, James J. Dowling
Summary: This study reported a new zebrafish model, zebrafish speg-DKO, of centronuclear myopathy (CNM), and demonstrated its ability to accurately recapitulate multiple phenotypes associated with CNM. This model provides a potential platform for investigating disease mechanisms and evaluating potential therapies for CNM.
DISEASE MODELS & MECHANISMS
(2022)