Mechanistic Insights into Axenfeld–Rieger Syndrome from Zebrafish foxc1 and pitx2 Mutants

Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation

(2021) Pengfei Xu et al.   eLife

The Axenfeld–Rieger Syndrome Gene FOXC1 Contributes to Left–Right Patterning

(2021) Paul W. Chrystal et al.   Genes

Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas

(2021) Francesco Girolamo et al.   Fluids and Barriers of the CNS

Spatiotemporal Characterization of Anterior Segment Mesenchyme Heterogeneity During Zebrafish Ocular Anterior Segment Development

(2020) Kristyn L. Van Der Meulen et al.   Frontiers in Cell and Developmental Biology

Sensorineural hearing loss and hypoplastic cochlea in Axenfeld-Rieger syndrome with FOXC1 mutation

(2020) Hiroshi Yamazaki et al.   AURIS NASUS LARYNX

Disruption of foxc1 genes in zebrafish results in dosage-dependent phenotypes overlapping Axenfeld-Rieger syndrome

(2020) Jesús-José Ferre-Fernández et al.   HUMAN MOLECULAR GENETICS

Axenfeld-Rieger syndrome-associated mutants of the transcription factor FOXC1 abnormally regulate NKX2-5 in model zebrafish embryos

(2020) Qinxin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The heart of the neural crest: cardiac neural crest cells in development and regeneration

(2020) Rajani M. George et al.   DEVELOPMENT

Loss of foxc1 in zebrafish reduces optic nerve size and cell number in the retinal ganglion cell layer

(2019) Jurgienne Umali et al.   VISION RESEARCH

CNS small vessel disease

(2019) Rocco J. Cannistraro et al.   NEUROLOGY

A novel frameshift mutation in the PITX2 gene in a family with Axenfeld-Rieger syndrome using targeted exome sequencing

(2019) Lusi Zhang et al.   BMC Medical Genetics

foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish

(2019) Thomas R. Whitesell et al.   DEVELOPMENTAL BIOLOGY

Valves Are a Conserved Feature of the Zebrafish Lymphatic System

(2019) Masahiro Shin et al.   DEVELOPMENTAL CELL

Neural crest development: insights from the zebrafish

(2019) Manuel Rocha et al.   DEVELOPMENTAL DYNAMICS

Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model

(2019) Michelle M. Collins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Childhood glaucoma genes and phenotypes: Focus on FOXC1 mutations causing anterior segment dysgenesis and hearing loss

(2019) Angela C. Gauthier et al.   EXPERIMENTAL EYE RESEARCH

Axenfeld-Rieger syndrome

(2018) M. Seifi et al.   CLINICAL GENETICS

Fox proteins are modular competency factors for facial cartilage and tooth specification

(2018) Pengfei Xu et al.   DEVELOPMENT

PITX2 deficiency and associated human disease: insights from the zebrafish model

(2018) Kathryn E Hendee et al.   HUMAN MOLECULAR GENETICS

Relationship between neural crest cell specification and rare ocular diseases

(2018) Monica Akula et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration

(2018) Michelle M Collins et al.   eLife

The transcription factor Foxc1a in zebrafish directly regulates expression ofnkx2.5, encoding a transcriptional regulator of cardiac progenitor cells

(2017) Yunyun Yue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs

(2016) Yongchang Ji et al.   DEVELOPMENTAL BIOLOGY

Zebrafish foxc1a drives appendage-specific neural circuit development

(2015) S. Banerjee et al.   DEVELOPMENT

Zebrafishfoxc1aPlays a Crucial Role in Early Somitogenesis by Restricting the Expression ofaldh1a2Directly

(2015) Jingyun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Description of Eye Defects in the Zebrafish Pax6b Mutant, sunrise, Reveals a Pax6b-Dependent Genetic Network in the Developing Anterior Chamber

(2015) Masanari Takamiya et al.   PLoS One

PITX2 Loss-of-Function Mutation Contributes to Congenital Endocardial Cushion Defect and Axenfeld-Rieger Syndrome

(2015) Cui-Mei Zhao et al.   PLoS One

Clarifying the role ofATOH7in glaucoma endophenotypes

(2014) Cristina Venturini et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease

(2014) Curtis R. French et al.   JOURNAL OF CLINICAL INVESTIGATION

Selection and constraint underlie irreversibility of tooth loss in cypriniform fishes

(2014) S. R. Aigler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalence and spectrum of PITX2c mutations associated with familial atrial fibrillation

(2013) Yi-Qing Yang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A novel PITX2c loss-of-function mutation underlies lone atrial fibrillation

(2013) YI-MENG ZHOU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cardiac anomalies in Axenfeld-Rieger syndrome due to a novelFOXC1mutation

(2012) Karen W. Gripp et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

CYP1B1, MYOC, and LTBP2 Mutations in Primary Congenital Glaucoma Patients in the United States

(2012) Sing-Hui Lim et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous

(2012) Lev Prasov et al.   HUMAN MOLECULAR GENETICS

pitx2 Deficiency Results in Abnormal Ocular and Craniofacial Development in Zebrafish

(2012) Yi Liu et al.   PLoS One

Hedgehog signaling is required at multiple stages of zebrafish tooth development

(2010) William R Jackman et al.   BMC DEVELOPMENTAL BIOLOGY

Genome-wide association identifies ATOH7 as a major gene determining human optic disc size

(2010) Stuart Macgregor et al.   HUMAN MOLECULAR GENETICS

A Genome-Wide Association Study of Optic Disc Parameters

(2010) Wishal D. Ramdas et al.   PLoS Genetics

FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation

(2009) Kimberly A Aldinger et al.   NATURE GENETICS

Sequential and cooperative action of Fgfs and Shh in the zebrafish retina

(2008) Saradavey Vinothkumar et al.   DEVELOPMENTAL BIOLOGY

Fgf19 is required for zebrafish lens and retina development

(2007) Yoshiaki Nakayama et al.   DEVELOPMENTAL BIOLOGY