Article
Chemistry, Multidisciplinary
Jin Beom Kwon, Maeum Han, Dong Geon Jung, Seong Ho Kong, Daewoong Jung
Summary: The study focuses on solution-processed PbS SWIR photodetectors with high sensitivity and reduced harmful effects on the human eye. By using PbS quantum dots and P3HT, SWIR photodetectors were successfully fabricated, resulting in a 2.26 times increase in responsivity.
Article
Chemistry, Multidisciplinary
Gyudong Lee, Woo Hyeon Jeong, Beomjoo Kim, Sungwoong Jeon, Andrew M. Smith, Jongcheol Seo, Kengo Suzuki, Jin-young Kim, Hyunki Lee, Hongsoo Choi, Dae Sung Chung, Jongmin Choi, Hyosung Choi, Sung Jun Lim
Summary: Engineered CdxHg1-xSe/HgS/CdyZn1-yS core/multi-shell quantum dots with bright tissue-penetrating shortwave infrared (SWIR) photoluminescence (PL) are developed. The compositional sequence facilitates uniform and coherent shell growth, resulting in high PL quantum yields (QYs) in both organic and aqueous solvents. The SWIR-luminescent composites made from these quantum dots show great potential as luminescent probes for deep-tissue imaging.
Article
Chemistry, Physical
Emily D. Cosco, Irene Lim, Ellen M. Sletten
Summary: ICG is widely used as a standard for photophysical properties and biological performance in optical imaging using near-infrared and shortwave infrared wavelengths. However, the variability of ICG's photophysical properties in different solvents hinders its ability to be used as a consistent benchmark.
Article
Chemistry, Multidisciplinary
Liuchong Fu, Yuming He, Jiajia Zheng, Yuxuan Hu, Jiayou Xue, Sen Li, Ciyu Ge, Xuke Yang, Meng Peng, Kanghua Li, Xiangbin Zeng, Jinchao Wei, Ding-jiang Xue, Haisheng Song, Chao Chen, Jiang Tang
Summary: A low-cost, high-performance, and high-stability TexSe1-x short-wave infrared photodiode detector is reported, demonstrating the potential of direct integration on CMOS readout circuits. The device shows broad-spectrum response, high detectivity, wide bandwidth, and linear dynamic range, while achieving high electric and thermal stability. Material identification and masking imaging applications are demonstrated based on the optimized TexSe1-x photodiode detector.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shu-Lan Li, Peng Jiang, Siyu Hua, Feng-Lei Jiang, Yi Liu
Summary: This study reported a simple one-step synthesis method for ultrasmall Zn-doped Cu2S QDs with high CDT activity and fluorescence imaging capability. The QDs were able to specifically inhibit cancer cell growth and induce apoptosis via a Fenton-like reaction, showing potential as multi-functional theranostic agents.
Article
Chemistry, Multidisciplinary
Irene Lim, Eric Yu Lin, Joseph Garcia, Shang Jia, Robert E. Sommerhalter, Subrata K. Ghosh, John A. Gladysz, Ellen M. Sletten
Summary: Developing chemical tools to detect and influence biological processes is important in chemical biology. In this study, we combined perfluorocarbons and multiplexed shortwave infrared fluorescence imaging to visualize nanoemulsions in real time in living mice. We prepared two fluorous-soluble chromenylium polymethine dyes that emit shortwave infrared light and successfully tracked the biodistribution of perfluorocarbon nanoemulsions in vivo. Our findings provided insight into the significance of size and surfactant identity on biodistribution.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Mahadeva M. M. Swamy, Setsuko Tsuboi, Yuta Murai, Kenji Monde, Takashi Jin
Summary: Recently, there has been significant interest in shortwave infrared (SWIR) fluorescence imaging over 1000 nm for in vivo optical imaging due to its higher signal to background ratios. This study focused on the development of biocompatible SWIR fluorescent molecular probes, specifically, indocyanine green (ICG) and pi-conjugation extended ICG (ICG-C11) labelled annexin V, for tumor apoptosis imaging. The researchers successfully synthesized SWIR emitting annexin V and demonstrated its capability for high-contrast fluorescence imaging of tumor apoptosis in living mice.
Article
Nanoscience & Nanotechnology
Tao Guo, Qiuyu Tang, Yating Guo, Honglong Qiu, Jing Dai, Chao Xing, Shihao Zhuang, Guoming Huang
Summary: Photothermal therapy is a promising new tumor treatment method, and the study found that the synthesized boron quantum dots have excellent biological safety and high photothermal conversion ability, making them suitable for tumor photothermal therapy applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Thomas De Kerf, Georgios Pipintakos, Zohreh Zahiri, Steve Vanlanduit, Paul Scheunders
Summary: This study proposes a new method to identify corrosion minerals in carbon steel using hyperspectral imaging in the shortwave infrared range. By artificially corroding samples and applying a normalized cross-correlation algorithm with reference spectra, four different corrosion minerals were accurately identified. In addition, the hyperspectral imaging technique can predict changes in mineral composition over time.
Article
Chemistry, Analytical
Lei Feng, Xiaoying He, Yacan Li, Lidong Wei, Yunfeng Nie, Juanjuan Jing, Jinsong Zhou
Summary: This article presents a compact prism imaging spectrometer method, utilizing a catadioptric curved prism to optimize the optical design process and reduce system volume. The laboratory testing results demonstrate excellent optical performance and a significant decrease in spectrometer length under the same specifications.
Article
Materials Science, Multidisciplinary
Setsuko Tsuboi, Takashi Jin
Summary: Gold nanoclusters (Au-NCs) are unique fluorescent nanomaterials used for bioimaging, with emission wavelengths depending on their size. Shortwave-infrared emitting Au-NCs have gained attention for deep tissue imaging and high-contrast images. Developing biocompatible SWIR fluorescent probes, like Au-NCs@BSA, is crucial for successful in vivo SWIR fluorescence imaging.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2021)
Article
Optics
Zehui Wang, Yongmin Duan, Panpan Li, Shiqing Xu, Junjie Zhang
Summary: In this study, a new material with shortwave shielding effect was successfully prepared by adding V5+ in CsPbBr3 QDs glass, which exhibits superior shielding effect in the blue wavelength band.
JOURNAL OF LUMINESCENCE
(2022)
Review
Chemistry, Multidisciplinary
Lu-Lu Chen, Liang Zhao, Zhi-Gang Wang, Shu-Lin Liu, Dai-Wen Pang
Summary: NIR-II imaging breakthrough imaging limitations in deep tissues, while NIR-II quantum dots exhibit excellent optical properties and have become promising fluorescent biomarkers in in vivo fluorescence imaging.
Article
Chemistry, Analytical
Jing Yang, Hao Liu, Yan Huang, Li Li, Xiaoli Zhu, Yaping Ding
Summary: In this paper, near-infrared carbon quantum dots (NIR-CQDs) were prepared and applied for fluorescence sensing of cortisol. NIR-CQDs-Apt can adsorb on the surface of graphene oxide (GO) and exhibit an inner filter effect (IFE). The presence of cortisol disrupts the IFE process, resulting in the recovery of NIR-CQDs-Apt fluorescence. This sensor shows excellent selectivity and a low detection limit, making it suitable for intracellular cortisol detection.
Article
Nanoscience & Nanotechnology
Di Cui, Lixia Han, Wei Jiang, Ligang Chen, Na Niu
Summary: Ag2-3xBixS quantum dots have been synthesized as potential theranostic nanomaterials for NIR-II fluorescence imaging and photothermal therapy. Bismuth doping in Ag2S QDs leads to a red shift in fluorescence and enhanced photothermal conversion efficiency. The albumin biomineralization method allows controlled synthesis of this NIR-II theranostic agent with improved biocompatibility and stability. In vivo experiments confirm the desirable fluorescence imaging capability of Ag2-3xBixS QDs.
ACS APPLIED NANO MATERIALS
(2023)
Article
Orthopedics
Hong-Yun Li, Ao Guo, Fan Yang, Jie-Jiao Zheng, Ying-Hui Hua, Shi-Yi Chen
Summary: This study revealed that the ATFL-PTFL angle decreases significantly after ankle lateral stabilization surgery. The angle was smaller in the repair group compared to the reconstruction group both before and after surgery. The ROC curve analysis showed that an ATFL-PTFL angle > 89.4 degrees is indicative of the need for ligament reconstruction.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Engineering, Biomedical
Jingming Gao, Xiaoquan Ding, Xiaoye Yu, Xiaobin Chen, Xingyu Zhang, Shuquan Cui, Jiayue Shi, Jun Chen, Lin Yu, Shiyi Chen, Jiandong Ding
Summary: The researchers developed a bilayered porous scaffold made of gelatin hydrogel and successfully fabricated it using continuous 3D-printing. The scaffold, when implanted in rabbit joints, showed excellent regeneration of cartilage, indicating its potential as a biomaterial for articular cartilage regeneration.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Wenbo Chen, Yaying Sun, Xueping Gu, Jiangyu Cai, Xingwang Liu, Xingyu Zhang, Jiwu Chen, Yuefeng Hao, Shiyi Chen
Summary: Stem cell-related therapies play a significant role in rotator cuff repair, with their secretome having a significant impact on tendon-bone healing. Research indicates that by modulating macrophage polarization, the conditioned medium of stem cells can promote faster tendon-bone healing.
Article
Engineering, Biomedical
Liang Hao, Jun Chen, Xiliang Shang, Shiyi Chen
Summary: The study found that the simvastatin-loaded silk fibroin membrane had better biocompatibility, promoting the proliferation and osteogenic differentiation of BMSCs, as well as enhancing tendon bone healing and reducing inflammation in chronic rotator cuff injuries. Additionally, it was shown to promote collagen formation and osteogenic differentiation of BMSCs through the activation of the beta-catenin signaling pathway. These results suggest that surface modification of simvastatin-loaded silk fibroin could be a potential strategy for improving healing in rotator cuff injuries and could be applied in clinical practice in the future.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Engineering, Biomedical
Xingyu Zhang, Jianjun Yang, Baochang Cheng, Shenli Zhao, Yao Li, Hui Kang, Shiyi Chen
Summary: A therapeutic drug delivery strategy using magnetic nanoparticles as carriers for cartilage repair was proposed. The magnetic nanocarriers were shown to promote chondrocyte viability and generate cartilage regeneration in a cartilage transplantation model, improving pain-related motor functions.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yang Wu, Yuhan Zhang, Ren Zhang, Shiyi Chen
Summary: This study successfully improved the biocompatibility and antibacterial properties of PET artificial ligament by coating a nano-PDA layer on its surface and introducing nHA and silver atoms.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Health Care Sciences & Services
Ling Zhang, Mengning Yan, Shiyi Chen, Yinghui Hua, Zimin Wang, Lili Xu, Shuai Fan, Lu Lin, Bin Cai
Summary: The study aims to determine if MUA is non-inferior to LOA in improving clinical outcomes after arthroscopic knee surgery within 3 to 6 months. A multicentre RCT with 360 patients will be conducted to compare the effectiveness of both procedures, with knee flexion range as the primary outcome measure.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Orthopedics
Yimeng Yang, Longhua Qiu, Xueping Gu, Jun Chen, Shiyi Chen, Dan Hu, Yuefeng Hao, Xiliang Shang
Summary: The validity of T1 mapping in monitoring fatty infiltration (FI) progression of rotator cuff muscles was investigated in this study. The results demonstrated that T1 mapping can effectively and quantitatively monitor the FI progression in rotator cuff muscles.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Engineering, Biomedical
K. Sun, R. Fu, X. W. Liu, L. M. Xu, G. Wang, S. Y. Chen, Q. J. Zhai, S. Pauly
Summary: This study found that Zr-based BMG shows excellent cytocompatibility, promotes bone formation, stimulates blood vessel formation, and reduces the pain level during recovery, making it a suitable candidate for biomedical applications.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Xiaoquan Ding, Jingming Gao, Xiaoye Yu, Jiayue Shi, Jun Chen, Lin Yu, Shiyi Chen, Jiandong Ding
Summary: In this study, a bilayered porous scaffold with bioactive peptides was constructed for osteochondral repair. The scaffold showed promising therapeutic efficacy in promoting tissue regeneration and restoring animal gait behavior.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Zhengchao Yuan, Dandan Sheng, Liping Jiang, Muhammad Shafiq, Atta ur Rehman Khan, Rashida Hashim, Yujie Chen, Baojie Li, Xianrui Xie, Jun Chen, Yosry Morsi, Xiumei Mo, Shiyi Chen
Summary: This study developed VEGF-binding aligned electrospun PCL/Gel scaffolds by incorporating BP sequence and demonstrated their potential in promoting ligament regeneration. The functionalized scaffolds accumulated VEGF, enhanced tubular formation of HUVECs and wound healing in vitro, and facilitated the regeneration of matured collagen in patellar ligament in vivo.
ACTA BIOMATERIALIA
(2022)
Letter
Medicine, General & Internal
Zhi-Wen Luo, Ya-Ying Sun, Wei Xia, Jun-Ying Xu, Dong-Jing Xie, Chun-Meng Jiao, Ji-Ze Dong, Hui Chen, Ren-Wen Wan, Shi-Yi Chen, Jie Mei, Wen-Jun Mao
MILITARY MEDICAL RESEARCH
(2023)
Article
Orthopedics
Mo Chen, Sijia Feng, Yuzhou Chen, Zheci Ding, Yuxue Xie, Jiwu Chen, Yinghui Hua, Jun Chen, Jianjun Yang, Shiyi Chen
Summary: The study found that female patients have a similar recurrence rate to male patients after arthroscopic anterior shoulder stabilization surgery. Despite poorer preoperative scores, women showed more significant improvements in postoperative shoulder function and range of motion.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Materials Science, Biomaterials
Zhuo Yan, Wenbo Chen, Wenhe Jin, Yaying Sun, Jiangyu Cai, Kai Gu, Ruixin Mi, Ni Chen, Shiyi Chen, Zhengzhong Shao
Summary: A novel silk-based bulk material with high content of hydroxyapatite-silk fibroin hybrid particles was developed, showing satisfactory cytocompatibility and osteoinductivity in vitro. This composite material shaped into interference screws exhibited remarkable biomechanical properties and significant new-bone ingrowth in a rabbit ACLR model, making it a potential candidate for clinical translation.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Nanoscience & Nanotechnology
Jun Chen, Dandan Sheng, Ting Ying, Haojun Zhao, Jian Zhang, Yunxia Li, He Xu, Shiyi Chen
Summary: The study introduces a NO-loaded metal-organic frameworks (MOFs) therapeutic system, NMPGA, which can promote tendon regeneration through angiogenesis, improve tubular formation capability of endothelial cells, and accelerate blood perfusion near the injured tendon, leading to faster collagen maturation and biomechanical strength recovery of regenerated tendon tissue.
NANO-MICRO LETTERS
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
