Review
Chemistry, Physical
S. Thanka Rajan, A. Arockiarajan
Summary: Amorphous thin film metallic glasses (TFMGs) have generated significant interest for their potential in practical applications and scientific importance in the biomedical field.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Materials Science, Ceramics
Wei Yang, Ying Liu, Nengbin Hua, Shujie Pang, Yan Li, Peter K. Liaw, Tao Zhang
Summary: Ni-free Ti-based bulk metallic glasses with high glass-forming ability can be synthesized in a wide composition range by copper-mold casting. These glasses displayed good bio-corrosion resistance and biocompatibility in a simulated physiological environment, making them promising candidates as biomaterials.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2021)
Article
Materials Science, Multidisciplinary
S. Jagdale, Q. Hu, M. Ecker, G. Kumar
Summary: A study comparing the in vitro cell response and thermoplastic formability of Ni-free and Ni-containing Pt-based metallic glasses revealed that the Ni-free Pt-Cu-Ag-P metallic glass combines the best combination of biocompatibility and thermoplastic forming. This finding has important implications for biomedical applications of metallic glasses.
Article
Chemistry, Physical
Kun Li, Zeyun Cai, Peng Du, Tao Xiang, Xinxin Yang, Guoqiang Xie
Summary: In this study, nano Fe particles reinforced Mg66Zn30Ca4 bulk metallic glass composites were prepared via spark plasma sintering, resulting in improved strength and corrosion resistance. The addition of Fe nanoparticles also promoted cell proliferation in vitro experiments, making the composites a promising candidate for degradable implant materials.
Review
Chemistry, Physical
Francesco Baino, Maziar Montazerian, Enrica Verne
Summary: Improving angiogenesis is crucial for successful regenerative medicine approaches, and cobalt-doped bioactive glasses offer potential by combining traditional bioactivity with pro-angiogenic effects. Concerns about possible toxic effects on cells and tissues have been raised, but important biological improvements have been observed in vitro and in vivo. This review provides an overview of biomedical applications of Co-releasing glasses, including various products and their therapeutic applications in bone repair, wound healing, and cancer treatment, along with existing evidence and future challenges.
Article
Materials Science, Biomaterials
Lidong Huang, Weiyu Gong, Guibin Huang, Jingyi Li, Jilin Wu, Yanmei Dong
Summary: Bioactive glasses (BG) are commonly used in bone defect repair for their osteoinductivity and osteoconductivity. However, the early angiogenesis of BG may not be sufficient to support new bone formation in large-sized defects. Photobiomodulation (PBM) therapy, known for promoting early angiogenesis, may enhance the angiogenesis of BG and improve the bone repair. In this study, BG combined with PBM showed additive effects on bone regeneration, enhancing cell proliferation, gene expression, mineralization, new bone formation, and bone reconstruction.
REGENERATIVE BIOMATERIALS
(2023)
Article
Chemistry, Physical
B. Subramanian, P. Sasikumar, S. Thanka Rajan, K. Gopal Shankar, Murugan Veerapandian
Summary: This study developed a novel ternary amorphous alloy (Zr54Ti35Si11) coating using DC magnetron sputtering technique, which exhibited excellent corrosion resistance and bioactivity for biomedical implant application.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Biotechnology & Applied Microbiology
Yiding Shen, Kai Fang, Yun Xiang, Keyuan Xu, Liang Yu, Jiaquan Chen, Pingping Ma, Kaiyong Cai, Xinkun Shen, Jinsong Liu
Summary: Titanium (Ti) implants are commonly used for tooth loss treatment due to their excellent biocompatibility and mechanical properties. However, improving the biological properties of Ti implants to enhance osteointegration remains a challenge. Micro-arc oxidation (MAO) has been proposed as a surface modification technique to improve the comprehensive properties of Ti by forming a protective oxide layer.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Kai-Ming Han, Hui Jiang, Ying-Min Wang, Jian-Bing Qiang
Summary: The addition of Ti was found to significantly affect the glass-forming ability and mechanical properties of Zr63.5-xTixAl9Fe4.5Cu23 BMGs. Higher Ti content initially increased the GFA and room-temperature plasticity of the BMGs, but this trend reversed after reaching a certain threshold. The Zr60.5Ti3Al9Fe4.5Cu23 BMGs showed excellent biocompatibility, biocorrosion resistance, and potential for use in biomedical devices.
Article
Materials Science, Multidisciplinary
Weiping Zeng, Yanhua Chen, Qiang Li, He Li, Baoxia Mu, Jiankang Ye, Chuntao Chang
Summary: The effects of Co content on the properties of Ni-based bulk metallic glasses were systematically investigated. It was found that increasing Co content improves glass forming ability, plastic strain, and corrosion resistance. These Ni-based bulk metallic glasses have excellent comprehensive performance and great potential for industrial applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Proceedings Paper
Materials Science, Multidisciplinary
Arun Pratap, Supriya Kasyap, Sonal Prajapati, Deepak Upadhyay
Summary: This study investigates the bio-corrosion resistance of two Fe-based metallic glasses and studied their bio-compatibility in four simulated body fluids. Potentiodynamic polarization studies were conducted to understand their bio-compatibility. Overall, the research highlights the importance of alloying elements in influencing the corrosion resistance of metallic glasses.
MATERIALS TODAY-PROCEEDINGS
(2021)
Article
Chemistry, Physical
Pingjun Tao, Huajie He, Yugan Chen, Ziyun Long, Weijian Zhang, Yuanzheng Yang
Summary: The effect of adding N on the thermodynamics and corrosion resistance of as-cast Zr55Cu30Ni5Al10 bulk metallic glass (BMG) was investigated. Nitrogen-doped BMG was found to have easier nucleation but more difficult nucleation growth compared to non-doped BMG. Nitrogen doping increased the corrosion potential slightly, but decreased the corrosion current density by about three orders of magnitude. Nitrogen also improved the oxide film resistance, weakened the surface corrosion diffusion effect, and enhanced the corrosion resistance of Zr-based BMGs.
Review
Chemistry, Multidisciplinary
Huafang Li, Pengyu Wang, Cuie Wen
Summary: Nanocrystalline metallic materials exhibit better mechanical properties, corrosion resistance, and biocompatibility compared to their coarse-grained counterparts. This review summarizes the mechanical properties, corrosion behavior, biocompatibility, and clinical applications of different types of nanocrystalline metallic materials. The special nanostructures of nanocrystalline materials, such as Ti and Ti alloys, shape memory alloys, stainless steels, and biodegradable Fe and Mg alloys prepared by high-pressure torsion, equiangular extrusion techniques, contribute to their superior properties. The review also provides guidance and references for future research on nanocrystalline metallic materials for biomedical applications.
Review
Materials Science, Ceramics
Li Jiang, Mianyu Bao, Yanmao Dong, Yan Yuan, Xing Zhou, Xiangkang Meng
Summary: Metallic glass (MG) is a new type of multi-component alloy with a unique disordered atomic stacking structure, which is gradually recognized as a promising anticorrosive material. This review focuses on the current studies and developments concerning corrosion resistant MGs, and provides valuable suggestions for subsequent research.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Chemistry, Applied
Tianxiao Wang, Yingchao Xu, Ziqi Liu, Guangyu Li, Yunting Guo, Jianshe Lian, Zhihui Zhang, Luquan Ren
Summary: In this study, a chitosan/polylactic acid composite coating was developed to enhance the corrosion resistance and biocompatibility of magnesium alloys. The composite coating sealed the pores of the chitosan layer, providing strong protection for the AZ31 alloy and significantly reducing the corrosion current density.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Orthopedics
Hong-Yun Li, Ao Guo, Fan Yang, Jie-Jiao Zheng, Ying-Hui Hua, Shi-Yi Chen
Summary: This study revealed that the ATFL-PTFL angle decreases significantly after ankle lateral stabilization surgery. The angle was smaller in the repair group compared to the reconstruction group both before and after surgery. The ROC curve analysis showed that an ATFL-PTFL angle > 89.4 degrees is indicative of the need for ligament reconstruction.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Engineering, Biomedical
Jingming Gao, Xiaoquan Ding, Xiaoye Yu, Xiaobin Chen, Xingyu Zhang, Shuquan Cui, Jiayue Shi, Jun Chen, Lin Yu, Shiyi Chen, Jiandong Ding
Summary: The researchers developed a bilayered porous scaffold made of gelatin hydrogel and successfully fabricated it using continuous 3D-printing. The scaffold, when implanted in rabbit joints, showed excellent regeneration of cartilage, indicating its potential as a biomaterial for articular cartilage regeneration.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Wenbo Chen, Yaying Sun, Xueping Gu, Jiangyu Cai, Xingwang Liu, Xingyu Zhang, Jiwu Chen, Yuefeng Hao, Shiyi Chen
Summary: Stem cell-related therapies play a significant role in rotator cuff repair, with their secretome having a significant impact on tendon-bone healing. Research indicates that by modulating macrophage polarization, the conditioned medium of stem cells can promote faster tendon-bone healing.
Article
Engineering, Biomedical
Liang Hao, Jun Chen, Xiliang Shang, Shiyi Chen
Summary: The study found that the simvastatin-loaded silk fibroin membrane had better biocompatibility, promoting the proliferation and osteogenic differentiation of BMSCs, as well as enhancing tendon bone healing and reducing inflammation in chronic rotator cuff injuries. Additionally, it was shown to promote collagen formation and osteogenic differentiation of BMSCs through the activation of the beta-catenin signaling pathway. These results suggest that surface modification of simvastatin-loaded silk fibroin could be a potential strategy for improving healing in rotator cuff injuries and could be applied in clinical practice in the future.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Engineering, Biomedical
Xingyu Zhang, Jianjun Yang, Baochang Cheng, Shenli Zhao, Yao Li, Hui Kang, Shiyi Chen
Summary: A therapeutic drug delivery strategy using magnetic nanoparticles as carriers for cartilage repair was proposed. The magnetic nanocarriers were shown to promote chondrocyte viability and generate cartilage regeneration in a cartilage transplantation model, improving pain-related motor functions.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yang Wu, Yuhan Zhang, Ren Zhang, Shiyi Chen
Summary: This study successfully improved the biocompatibility and antibacterial properties of PET artificial ligament by coating a nano-PDA layer on its surface and introducing nHA and silver atoms.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Health Care Sciences & Services
Ling Zhang, Mengning Yan, Shiyi Chen, Yinghui Hua, Zimin Wang, Lili Xu, Shuai Fan, Lu Lin, Bin Cai
Summary: The study aims to determine if MUA is non-inferior to LOA in improving clinical outcomes after arthroscopic knee surgery within 3 to 6 months. A multicentre RCT with 360 patients will be conducted to compare the effectiveness of both procedures, with knee flexion range as the primary outcome measure.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Orthopedics
Yimeng Yang, Longhua Qiu, Xueping Gu, Jun Chen, Shiyi Chen, Dan Hu, Yuefeng Hao, Xiliang Shang
Summary: The validity of T1 mapping in monitoring fatty infiltration (FI) progression of rotator cuff muscles was investigated in this study. The results demonstrated that T1 mapping can effectively and quantitatively monitor the FI progression in rotator cuff muscles.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Xiaoquan Ding, Jingming Gao, Xiaoye Yu, Jiayue Shi, Jun Chen, Lin Yu, Shiyi Chen, Jiandong Ding
Summary: In this study, a bilayered porous scaffold with bioactive peptides was constructed for osteochondral repair. The scaffold showed promising therapeutic efficacy in promoting tissue regeneration and restoring animal gait behavior.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Zhengchao Yuan, Dandan Sheng, Liping Jiang, Muhammad Shafiq, Atta ur Rehman Khan, Rashida Hashim, Yujie Chen, Baojie Li, Xianrui Xie, Jun Chen, Yosry Morsi, Xiumei Mo, Shiyi Chen
Summary: This study developed VEGF-binding aligned electrospun PCL/Gel scaffolds by incorporating BP sequence and demonstrated their potential in promoting ligament regeneration. The functionalized scaffolds accumulated VEGF, enhanced tubular formation of HUVECs and wound healing in vitro, and facilitated the regeneration of matured collagen in patellar ligament in vivo.
ACTA BIOMATERIALIA
(2022)
Letter
Medicine, General & Internal
Zhi-Wen Luo, Ya-Ying Sun, Wei Xia, Jun-Ying Xu, Dong-Jing Xie, Chun-Meng Jiao, Ji-Ze Dong, Hui Chen, Ren-Wen Wan, Shi-Yi Chen, Jie Mei, Wen-Jun Mao
MILITARY MEDICAL RESEARCH
(2023)
Article
Orthopedics
Mo Chen, Sijia Feng, Yuzhou Chen, Zheci Ding, Yuxue Xie, Jiwu Chen, Yinghui Hua, Jun Chen, Jianjun Yang, Shiyi Chen
Summary: The study found that female patients have a similar recurrence rate to male patients after arthroscopic anterior shoulder stabilization surgery. Despite poorer preoperative scores, women showed more significant improvements in postoperative shoulder function and range of motion.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Materials Science, Biomaterials
Zhuo Yan, Wenbo Chen, Wenhe Jin, Yaying Sun, Jiangyu Cai, Kai Gu, Ruixin Mi, Ni Chen, Shiyi Chen, Zhengzhong Shao
Summary: A novel silk-based bulk material with high content of hydroxyapatite-silk fibroin hybrid particles was developed, showing satisfactory cytocompatibility and osteoinductivity in vitro. This composite material shaped into interference screws exhibited remarkable biomechanical properties and significant new-bone ingrowth in a rabbit ACLR model, making it a potential candidate for clinical translation.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Nanoscience & Nanotechnology
Jun Chen, Dandan Sheng, Ting Ying, Haojun Zhao, Jian Zhang, Yunxia Li, He Xu, Shiyi Chen
Summary: The study introduces a NO-loaded metal-organic frameworks (MOFs) therapeutic system, NMPGA, which can promote tendon regeneration through angiogenesis, improve tubular formation capability of endothelial cells, and accelerate blood perfusion near the injured tendon, leading to faster collagen maturation and biomechanical strength recovery of regenerated tendon tissue.
NANO-MICRO LETTERS
(2021)
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)
