Article
Chemistry, Organic
Mohan Sun, Xianjie Ma, Siyuan Shao, Jianwei Jiang, Jiaan Li, Jinying Tian, Jianjun Zhang, Li Li, Fei Ye, Shuai Li
Summary: Two pairs of novel trimeric compounds, along with four known compounds, were isolated from the tubers of Bletilla striata. Some of these compounds showed anti-inflammatory and anti-diabetic activities.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Mohan Sun, Xianjie Ma, Siyuan Shao, Jianwei Jiang, Jiaan Li, Jinying Tian, Jianjun Zhang, Li Li, Fei Ye, Shuai Li
Summary: In this study, novel compounds were isolated from Bletilla striata, showing anti-inflammatory and anti-diabetic activities. The structures and absolute configurations of the compounds were determined, and their potential mechanisms of action were investigated.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fei Zhou, Rui Feng, Ou Dai, Lian Yang, Yu Liu, Yun-Cai Tian, Cheng Peng, Liang Xiong
Summary: In this study, phenanthrene derivatives were isolated from the tubers of B. striata and one compound showed cytotoxicity against non-small cell lung cancer cells. It inhibited cell proliferation and migration and promoted cell apoptosis, possibly by regulating Akt, MEK/ERK, and Bcl-2/Bax signaling pathways.
Article
Chemistry, Multidisciplinary
Mei Zhou, Sai Jiang, Changfen Chen, Jinyu Li, Huayong Lou, Mengyun Wang, Gezhou Liu, Hanfei Liu, Ting Liu, Weidong Pan
Summary: Six new bibenzyls (three pairs of enantiomers), named bletstrins D-F (1-3), were isolated from the tubers of Bletilla striata. The structures and absolute configurations of these compounds were determined through various analyses. Compounds 1-3 possess a hydroxyl-substituted chiral center on the aliphatic bibenzyl bridge, which is the first discovery of natural bibenzyl enantiomers from the genus Bletilla. These compounds also demonstrated antibacterial, anti-TNF-alpha, and neuroprotective effects.
FRONTIERS IN CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Wen Cheng, Fangmei Zhou, Bingqi Zhu, Xinghong Ding, Jingjing Lu, Chaodong Qian, Xiaoqing Ye, Zhishan Ding
Summary: The study developed a multifunctional composite sponge dressing with hemostatic, anti-inflammatory, antibacterial, and wound healing promotion properties. In vivo and in vitro evaluations showed significant hemostatic and antibacterial effects, along with good biodegradability and biocompatibility. Experimental results demonstrated the sponge's effectiveness in promoting wound healing.
MATERIALS & DESIGN
(2021)
Article
Plant Sciences
Shao-wei Han, Xiao-juan Wang, Bao-song Cui, Hua Sun, Hui Chen, Daneel Ferreira, Shuai Li, Mark T. Hamann
Summary: Nine new glucosyloxybenzyl 2-hydroxy-2-isobutyl-succinates, pleionosides M-U (1-9), and 12 known compounds (10-21) were isolated from Pleione yunnanensis pseudobulbs. The structures and configurations were identified using HRESIMS and NMR data. Some compounds showed significant hepatoprotective activity against induced toxicity in liver cells, suggesting potential therapeutic applications.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Applied
Haoying Chen, Jinsong Zeng, Bin Wang, Zheng Cheng, Jun Xu, Wenhua Gao, Kefu Chen
Summary: This study investigated the different physicochemical properties and antioxidant activities of Bletilla striata polysaccharides obtained through various extraction methods. Among these polysaccharides, alkali-assisted extraction showed better radical scavenging activities, while hot water extraction exhibited superior hydroxyl radical scavenging activities.
CARBOHYDRATE POLYMERS
(2021)
Article
Plant Sciences
Leander Geske, Joris Baier, Joelle C. Boulos, Thomas Efferth, Till Opatz
Summary: The article reports the first total syntheses of orchid-derived natural products from renewable starting materials, along with evaluation of their potential to inhibit cancer cell growth.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Xiaolei Zhu, Jie Wang, Yi Fu, Aizhu Zhou, Menglu Ye, Muhammad Waheed Riaz, Bingcong Xing, Qingsong Shao
Summary: Bletilla striata, a plant with various ethnopharmacological uses, has been widely used in the treatment of hemorrhagic diseases and beauty care. It is rich in polysaccharides, which have anti-aging, whitening, and antioxidation functions, making it widely used in the cosmetics industry. The HL20 strain of B. striata has shown superior whitening and antimicrobial activity compared to the WT strain.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mo-Han Sun, Xian-Jie Ma, Si-Yuan Shao, Shao-Wei Han, Jian-Wei Jiang, Jian-Jun Zhang, Shuai Li
Summary: Thirteen new compounds, blestanols A-M, were isolated from tubers of Bletilla striata, alongside 12 known analogues. Among these compounds, 14 showed inhibition of NO production and eight displayed selective cytotoxic activities against certain cancer cell lines. The study also deduced a putative biosynthetic pathway for these compounds.
Article
Chemistry, Analytical
Xiuying Zhu, Hegui Yan, Minghui Yang, Xiaoqiong Yang, Lu He
Summary: This study established an HPLC method for determining the levels of phenanthrenes and bibenzyls in the rhizomes of P. articulata Lindl. The method showed good linearity and recovery rates, providing a foundation for further research on the biological activities of these compounds in natural products.
JOURNAL OF AOAC INTERNATIONAL
(2022)
Article
Chemistry, Applied
Guanghui Jiang, Bulei Wang, Yuwen Wang, Haoyue Kong, Yufei Wang, Peng Gao, Minghao Guo, Wenna Li, Jian Zhang, Zhezhi Wang, Junfeng Niu
Summary: This study extracted and purified a new low molecular weight neutral polysaccharide (B. striata glucomannan, BSP) from Bletilla striata and evaluated its activities for alleviating liver fibrosis. BSP was found to attenuate liver fibrosis through the TLR2/TLR4-MyD88-NF-kappa B signaling pathway, providing theoretical foundations for its potential application as an antiliver fibrosis platform.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Wanchen Zhai, Enwei Wei, Rui Li, Tianyi Ji, Yueyao Jiang, Xiaoxiao Wang, Yiying Liu, Zhiying Ding, Hongli Zhou
Summary: This study found that polysaccharides from Bletilla striata (BSP) exhibit pro-coagulant and immunomodulatory activities, making them a potential coagulant. BSP-2, in particular, showed significant enhancement in immunomodulatory activity.
Article
Biochemistry & Molecular Biology
Weihuan Zeng, Jun Qian, Yue Wang, Minyu Shou, Guoyin Kai
Summary: This study reports a Prussian blue-based photothermal responsive gel, PB-ISA/BSP gel, for effective treatment of bacterial infection and wound healing. The gel enhances sterilization efficiency through synergistic effects and accelerates wound healing process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Ming Zhou, Fang Yuan, Han-Li Ruan, Jun Li, Jun-Feng Huang, Si Liu, Tian-Yue Huang, Yan-Jun Zhang, Qiong Liang
Summary: This study isolated four new neolignan glycosides, named bletineosides A-D (1-4), from the pseudobulbs of Bletilla striata and demonstrated their neuroprotective activities. Compounds 1-4 represent the first examples of neolignan glycosides from the genus Bletilla, suggesting Bletilla striata as a potential source of anti-neurodegenerative agents.
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.