Article
Biochemistry & Molecular Biology
Jang-Chun Lin, Chun-Yuan Kuo, Jo-Ting Tsai, Wei-Hsiu Liu
Summary: This study suggests that the tumor marker MSI1 interacts with miR-671-5p and weakens its function, thereby regulating radioresistance, CSCs, and tumor activity in GBM. miR-671-5p may serve as a potential therapeutic target and predictive biomarker for GBM.
Article
Oncology
Huapeng Guan, Hao Xu, Jinshui Chen, Weishan Wu, Dongfeng Chen, Yungang Chen, Jianzhong Sun
Summary: The study found that circ_0001721 and TCF4 were upregulated, while miR-758 was downregulated in DXR-resistant OS tissues and cells. Circ_0001721 regulated DXR resistance through sponging miR-758, and miR-758 modulated DXR resistance by targeting TCF4. The knockdown of circ_0001721 inhibited tumor growth in vivo, suggesting its potential as a therapeutic target for OS treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Jr-Di Yang, Jui-Tai Chen, Shing-Hwa Liu, Ruei-Ming Chen
Summary: The testosterone androgen receptor (AR)-PARD3B signaling axis plays an important role in the tumorigenesis and malignancy of human glioblastoma multiforme (GBM) by stimulating cell proliferation and colony formation. The study found that AR and PARD3B gene expressions were upregulated in GBM tissues, and there was a strong positive correlation between their expressions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yuhang Wang, Binbin Wang, Fengqi Zhou, Kun Lv, Xiupeng Xu, Wenping Cao
Summary: Based on experiments, it was found that circNDC80 promotes the development of glioblastoma through the miR-139-5p/ECE1 pathway. This suggests that circNDC80 could serve as a novel therapeutic target and a potential predictive biomarker.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Siyuan Wang, Xiaorong Yang, Wenjie Xie, Shengqiang Fu, Qiang Chen, Zhilong Li, Zhicheng Zhang, Ting Sun, Binbin Gong, Ming Ma
Summary: Our study identified that GAPLINC is significantly upregulated in RCC tissues and cell lines, and is associated with a poor prognosis in RCC patients. Knockdown of GAPLINC inhibited RCC growth in vitro and in vivo, while overexpression of GAPLINC had the opposite effect. Mechanistically, GAPLINC upregulates the oncogene CSF1 expression by acting as a sponge for miR-135b-5p.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Sun Gui Feng, Rajeev Bhandari, Liu Ya, Bian Zhixuan, Pan Qiuhui, Zhu Jiabei, Mao Sewi, Zhen Ni, Wang Jing, Sun Fenyong, Ma Ji, Ramesh Bhandari
Summary: The study revealed that SNHG9 is upregulated in hepatoblastoma, with its overexpression promoting cell proliferation and colony formation, while knockdown inhibiting these activities. Various experimental methods confirmed the interaction between SNHG9, miR-23a-5p, and Wnt3a, highlighting its significant role in hepatoblastoma.
Article
Cell Biology
Xiangkun Wu, Lihua Yan, Yongxi Liu, Lilin Shang
Summary: Accumulating evidence indicates that circRNAs are crucial in the development of human tumors. In this study, circ_0000527 was found to be overexpressed in osteosarcoma cells, promoting cell growth and inflammatory mediator secretion by sponging miR-646 and modulating ARL2. The expression of miR-646 and ARL2 was dysregulated in osteosarcoma cells, and the level of circ_0000527 was negatively correlated with miR-646 expression in osteosarcoma specimens. The circ_0000527/miR-646/ARL2 axis may serve as a potential treatment target for osteosarcoma.
Article
Cell Biology
Ramesh Bhandari, Imran Ibrahim Shaikh, Rajeev Bhandari, Sadikchha Chapagain
Summary: This study reveals the important role of LINC01023 in the development of hepatoblastoma and suggests that it could be a potential therapeutic target and prognostic biomarker in hepatoblastoma.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jiutao Wang, Ning Yao, Yamei Hu, Mingjuan Lei, Meixian Wang, Lu Yang, Satyananda Patel, Xiang Li, Kangdong Liu, Zigang Dong
Summary: This study identified the potential mechanism of how Ras is activated in glioblastoma multiforme (GBM) through the interaction between Ras and PHLDA1. The overexpression of PHLDA1 promoted cell proliferation and tumor growth by regulating the Ras/Raf/Mek/Erk signaling pathway. In addition, Src phosphorylated Ras at tyrosine 32 to enhance its GTPase activity. PHLDA1 competed with Src for binding to Ras, inhibiting Ras phosphorylation by Src and rescuing Ras activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Deheng Li, Junda Hu, Sen Li, Changshuai Zhou, Mingtao Feng, Liangdong Li, Yang Gao, Xin Chen, Xiaojun Wu, Yiqun Cao, Bin Hao, Lei Chen
Summary: This study investigates the upstream regulatory lncRNAs and miRNAs of NUSAP1, a potential molecular marker and intervention target for glioblastoma. Multiple databases were used to screen for upstream lncRNAs and miRNAs of NUSAP1, and in vitro and in vivo experiments were conducted to elucidate their biological significance and regulatory mechanism. Clinical specimens confirmed the negative correlations between LINC01393 and miR-128-3p. Further experiments validated the LINC01393/miR-128-3p/NUSAP1 interactions. The study deepens understanding of GBM mechanisms and provides potential novel therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ping Zhao, Ting Li, Youliang Wang, Yong Wang, Qi Gu, Zhi Li
Summary: MYCNOS is upregulated in GBM tissues and may regulate FOXM1 expression by directly interacting with miR-216b, thereby promoting the proliferation of GBM cells.
METABOLIC BRAIN DISEASE
(2021)
Article
Anatomy & Morphology
Oguzhan Doganlar, Zeynep Banu Doganlar, Emre Delen, Ayten Dogan
Summary: The study showed that melatonin selectively induces cell death in GBM cells, impairs tumorigenesis and invasion, and reduces expression of key genes and proteins associated with tumour growth. Six angio-miRNAs were identified as potentially important players in GBM development, all of which respond to melatonin therapy.
Article
Biochemistry & Molecular Biology
Chenlong Li, Xue Guan, Hanguang Jing, Xu Xiao, Hua Jin, Jinsheng Xiong, Siqi Ai, Yingjie Wang, Tianqi Su, Guiyin Sun, Tianjiao Fu, Yujie Wang, Shouli Guo, Peng Liang
Summary: The present study found that the circular RNA bifunctional apoptosis regulator (circBFAR) is highly expressed in glioblastoma multiforme (GBM) and is negatively correlated with overall survival in patients. Inhibition of circBFAR can suppress the proliferation and invasion of GBM. The study also identified that circBFAR regulates the expression of FoxM1 through interaction with miR-548b.
Article
Biochemistry & Molecular Biology
Chenming Ni, Wenyu Liu, Kailian Zheng, Shiwei Guo, Bin Song, Wei Jing, Gang Li, Bo Li, Canrong Ni, Keqing Shi, Gang Jin, Guanzhen Yu
Summary: The study discovered the presence of the MLL-AFF4 fusion gene in acute leukemia and investigated the role of AFF4 in pancreatic tumorigenesis. The results showed that overexpression of AFF4 promoted cell proliferation and cell cycle progression, while two nucleotide metabolism enzymes, HPRT1 and IMPDH2, were upregulated. The study also found that AFF4 was regulated by the PI3K/c-Myc axis and was positively correlated with c-Myc and HPRT1/IMPDH2 expression in clinical PDAC samples. These findings establish AFF4 as a potential biomarker and therapeutic target for PDAC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jian Zhong, Xujia Wu, Yixin Gao, Junju Chen, Maolei Zhang, Huangkai Zhou, Jia Yang, Feizhe Xiao, Xuesong Yang, Nunu Huang, Haoyue Qi, Xiuxing Wang, Fan Bai, Yu Shi, Nu Zhang
Summary: The MET signalling pathway is crucial for maintaining glioblastoma (GBM) stem cells. Researchers have discovered a circular RNA from the MET gene (circMET) that produces a MET variant protein (MET404), which directly activates the MET receptor and promotes GBM tumorigenesis. This study uncovers hidden mechanisms of MET signalling in GBM and provides a potential therapeutic strategy for GBM patients.
NATURE COMMUNICATIONS
(2023)