Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXRα) and Pregnane X Receptor (PXR)

Flavonoids differentially modulate liver X receptors activity—Structure-function relationship analysis

(2019) Allan Fouache et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies

(2018) Yi-Wen Li et al.   ARCHIVES OF TOXICOLOGY

Of mice and men: Is there a future for metformin in the treatment of hepatic steatosis?

(2018) Charlotte J. Green et al.   DIABETES OBESITY & METABOLISM

Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis

(2018) Yen-Ning Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ursolic Acid, a Novel Liver X Receptor α (LXRα) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis

(2018) Yen-Ning Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ligands of Therapeutic Utility for the Liver X Receptors

(2017) Rajesh Komati et al.   MOLECULES

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis

(2016) Laia Tolosa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells

(2015) Robim M. Rodrigues et al.   ARCHIVES OF TOXICOLOGY

Targeting xenobiotic receptors PXR and CAR in human diseases

(2015) Monimoy Banerjee et al.   DRUG DISCOVERY TODAY

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent

(2014) X. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Sesamin Enhances Cholesterol Efflux in RAW264.7 Macrophages

(2014) Nan Liu et al.   MOLECULES

The lignan, (−)-sesamin reveals cytotoxicity toward cancer cells: Pharmacogenomic determination of genes associated with sensitivity or resistance

(2014) Mohamed Saeed et al.   PHYTOMEDICINE

Drug-Induced Hepatic Steatosis

(2014) Naga Chalasani et al.   SEMINARS IN LIVER DISEASE

Valproate-Induced Liver Injury: Modulation by the Omega-3 Fatty Acid DHA Proposes a Novel Anticonvulsant Regimen

(2014) Marwa A. Abdel-Dayem et al.   Drugs in research & development

Lignans of sesame: Purification methods, biological activities and biosynthesis – A review

(2013) Aejaz Ahmad Dar et al.   BIOORGANIC CHEMISTRY

Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by Liver X receptor α through a sterol regulatory element-binding protein 1c-dependent mechanism in mice

(2013) Jing Wu et al.   HEPATOLOGY

Ursodeoxycholic Acid Inhibits Liver X Receptor α-mediated Hepatic Lipogenesis via Induction of the Nuclear Corepressor SMILE

(2013) Ji-Min Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation

(2012) Yun-Ping Lim et al.   Evidence-based Complementary and Alternative Medicine

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Taurine is a liver X receptor-α ligand and activates transcription of key genes in the reverse cholesterol transport without inducing hepatic lipogenesis

(2012) Minh-Hien Hoang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human SREBP1c Expression in Liver Is Directly Regulated by Peroxisome Proliferator-activated Receptor α (PPARα)

(2011) Ana Fernández-Alvarez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular characterization of SMILE as a novel corepressor of nuclear receptors

(2009) Yuan-Bin Xie et al.   NUCLEIC ACIDS RESEARCH

Synthesis of riccardin C and its seven analogues. Part 1: The role of their phenolic hydroxy groups as LXRα agonists

(2008) Hideaki Hioki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease

(2008) Nobito Higuchi et al.   HEPATOLOGY RESEARCH

Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia

(2008) Adelheid Kratzer et al.   JOURNAL OF LIPID RESEARCH