Article
Environmental Sciences
Zhihua Qiao, Kailun Luo, Shanqi Zhou, Mengru Fu, Xuechun Shao, Kailin Gong, Cheng Peng, Wei Zhang
Summary: DBDPE and Cd are commonly found contaminants in e-waste, which can accumulate in the environment during e-waste dismantling. This study investigated their accumulation and phytotoxicity mechanisms using lettuce. The results showed that exposure to 1 mg/L Cd + DBDPE reduced Cd toxicity to lettuce, while exposure to 5 mg/L Cd + DBDPE increased Cd toxicity. Additionally, combined exposure affected amino acid metabolism, carbon metabolism, and ABC transport in lettuce.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Eva Lipicar, Danijela Fras, Nino Javernik, Helena Prosen
Summary: Flame retardants, such as PBDEs and HBCDDs, have been widely used in consumer products for fire prevention but have been recognized as persistent organic pollutants with adverse effects. This study developed a method for simultaneously analyzing PBDEs and HBCDDs in food. The method involved single sample preparation using ultrasound-assisted extraction and chromatography. The method was validated using milk formula samples and showed satisfactory accuracy and precision. The method's applicability was further confirmed using baby food, fish, and citrus samples.
Article
Biochemistry & Molecular Biology
Annick N. Enangue Njembele, Zoheir B. Demmouche, Janice L. Bailey, Jacques J. Tremblay
Summary: This study found that an environmentally relevant mixture of organochlorine chemicals (OCs) disrupts steroidogenesis in Leydig cells by decreasing the levels of the STAR protein, which is involved in cholesterol transportation for steroid hormone synthesis. Additionally, the OC mixture affects other proteins involved in mitochondrial transport, lipid metabolism, and steroidogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Christopher G. Goodchild, Natalie K. Karouna-Renier, Ryan P. Braham, Paula F. P. Henry, Robert J. Letcher, Kim J. Fernie
Summary: Brominated flame retardants are widely used in consumer products to reduce flammability. This study investigated the potential toxic effects of these flame retardants on American kestrel hatchlings. The results showed that these flame retardants can affect gene expression related to immune, thyroid, and other biological pathways, and there were significant differences in gene expression between male and female hatchlings.
Article
Biochemistry & Molecular Biology
Annick N. Enangue Njembele, Jacques J. Tremblay
Summary: Research shows that MEHP inhibits steroidogenesis in Leydig cells by affecting cholesterol transport and conversion to pregnenolone. Two novel plasticizers have no significant impact on hormone-induced steroidogenesis, making them potential alternatives to phthalates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Giulia Solazzo, Haotian Wu, Hannah E. Laue, Kasey Brennan, Julia M. Knox, Virginie Gillet, Amelie Bovin, Nadia Abdelouahab, Jonathan Posner, Elizabeth Raffanello, Sarah Pieper, Fredrick DuBois Bowman, Daniel Drake, Andrea A. Baccarelli, Larissa Takser
Summary: This study did not find a significant association between PBDE exposure and child cognitive and motor development. The impact of different PBDE concentrations during early and late pregnancy on children's neurodevelopment remains unclear.
ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Environmental Sciences
Giulia Solazzo, Haotian Wu, Hannah E. Laue, Kasey Brennan, Julia M. Knox, Virginie Gillet, Amelie Bovin, Nadia Abdelouahab, Jonathan Posner, Elizabeth Raffanello, Sarah Pieper, Fredrick DuBois Bowman, Daniel Drake, Andrea A. Baccarelli, Larissa Takser
Summary: This study investigated the association between PBDE concentration during early and late pregnancy and cognitive function in children aged 6-8 years. The results did not show a significant association between PBDE exposure and child cognitive and motor development.
ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Toxicology
Hongyan Dong, Michael G. Wade
TOXICOLOGY IN VITRO
(2017)
Article
Developmental Biology
Emily W. Y. Tung, Alice Kawata, Marc Rigden, Wayne J. Bowers, Don Caldwell, Alison C. Holloway, Bernard Robaire, Barbara F. Hales, Michael G. Wade
BIRTH DEFECTS RESEARCH
(2017)
Article
Pharmacology & Pharmacy
Michael G. Wade, Alice Kawata, Marc Rigden, Don Caldwell, Alison C. Holloway
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2019)
Article
Toxicology
Rita-Josiane Gouesse, Melanie Lavoie, Elham Dianati, Mike G. Wade, Barbara F. Hales, Bernard Robaire, Isabelle Plante
TOXICOLOGICAL SCIENCES
(2019)
Article
Toxicology
Hongyan Dong, Ella Atlas, Michael G. Wade
TOXICOLOGY IN VITRO
(2019)
Article
Toxicology
Hongyan Dong, Marlena Godlewska, Michael G. Wade
TOXICOLOGY IN VITRO
(2020)
Article
Toxicology
Adelaide Allais, Oceane Albert, Pavine L. C. Lefevre, Michael G. Wade, Barbara F. Hales, Bernard Robaire
TOXICOLOGICAL SCIENCES
(2020)
Article
Toxicology
Rita-Josiane Gouesse, Elham Dianati, Alec McDermott, Michael G. Wade, Barbara Hales, Bernard Robaire, Isabelle Plante
Summary: Exposure to environmentally relevant mixture of BFRs induces precocious development of the mammary gland in young animals, accelerating epithelial development, increasing cell proliferation and apoptosis, as well as the number of thyroid hormone receptor alpha 1 positive cells.
TOXICOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Bo Wang, Evangelia E. Tsakiridis, Shuman Zhang, Andrea Llanos, Eric M. Desjardins, Julian M. Yabut, Alexander E. Green, Emily A. Day, Brennan K. Smith, James S. Lally, Jianhan Wu, Amogelang R. Raphenya, Krishna A. Srinivasan, Andrew G. McArthur, Shingo Kajimura, Jagdish Suresh Patel, Michael G. Wade, Katherine M. Morrison, Alison C. Holloway, Gregory R. Steinberg
Summary: The commonly used pesticide chlorpyrifos reduces energy expenditure by inhibiting diet-induced thermogenesis, contributing to obesity and insulin resistance. The suppression of uncoupling protein 1 (UCP1) and mitochondrial respiration in brown adipose tissue (BAT) by chlorpyrifos suggests its potential contribution to the obesity epidemic.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Matthew J. Meier, K. C. Nguyen, J. Crosthwait, A. Kawata, M. Rigden, K. Leingartner, A. Wong, A. Holloway, P. S. Shwed, Lee Beaudette, M. Navarro, M. Wade, A. F. Tayabali
Summary: This study found that repeated ingestion of AgNP-containing consumer products in combination with antibiotics can lead to biological effects in mice, including slower weight gain, reduced peripheral lymphocytes, elevated splenic markers of inflammation, and significant alterations in the gut microbiota structure and function. The presence of silver was mainly found in the stomach and intestines of mice exposed to both AgNPs and antibiotics, with minimal tissue silver levels in mice exposed to AgNPs alone. Antibiotics, but not AgNPs, were found to impact glucose metabolism.
Article
Environmental Sciences
Anita A. Thambirajah, Michael G. Wade, Jonathan Verreault, Nicolas Buisine, Veronica A. Alves, Valerie S. Langlois, Caren C. Helbing
Summary: This critical review highlights the complexity of Endocrine Disrupting Chemicals interfering with Thyroid Hormone function through interactions with other hormonal axes, and emphasizes the lack of data generated in non-mammalian vertebrate classes. With the availability of more genomics-based resources, better identification and delineation of EDC effects, modes of action, and identification of effective biomarkers suitable for HPT disruption is possible. The effects of EDCs are likely to cascade into a plurality of complex physiological effects, beyond the few variables tested within research studies.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
G. Delbes, M. Blazquez, J. Fernandino, P. Grigorova, B. F. Hales, C. Metcalfe, L. Navarro-Martin, L. Parent, B. Robaire, A. Rwigemera, G. Van der Kraak, M. Wade, V Marlatt
Summary: Endocrine disrupting chemicals (EDCs) have been found to impact reproductive health, with early exposures during critical developmental stages having immediate effects on gonadal and reproductive tract development, as well as potential long-term effects on reproductive health in both males and females. Understanding the mechanisms regulating sex determination, differentiation, and gonadal development in fish and rodents has improved our understanding of how EDCs affect reproduction.
ENVIRONMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yun Han Kwon, Suhrid Banskota, Huaqing Wang, Laura Rossi, Jensine A. Grondin, Saad A. Syed, Yeganeh Yousefi, Jonathan D. Schertzer, Katherine M. Morrison, Michael G. Wade, Alison C. Holloway, Michael G. Surette, Gregory R. Steinberg, Waliul I. Khan
Summary: Chronic exposure to Allura Red AC increases susceptibility to colitis in mice dependent on the serotonin biosynthetic enzyme TPH1. Intermittent exposure, more typical for humans, does not increase susceptibility. The impact of chronic exposure to this common synthetic colorant on colitis is mediated through colonic 5-HT levels and is microbiota-dependent and -independent.
NATURE COMMUNICATIONS
(2022)
Article
Food Science & Technology
Evangelia E. Tsakiridis, Marisa R. Morrow, Eric M. Desjardins, Dongdong Wang, Andrea Llanos, Bo Wang, Michael G. Wade, Katherine M. Morrison, Alison C. Holloway, Gregory R. Steinberg
Summary: Metabolic diseases are increasing worldwide and exposure to pesticides and pollutants may contribute to this trend. This study investigated the effects of the pesticide deltamethrin on metabolic disease development in mice fed a high-fat diet and housed at different temperatures. The results showed that low doses of deltamethrin improved metabolic parameters, while higher doses had no effect. Importantly, deltamethrin did not alter BAT thermogenesis markers or worsen obesity and insulin resistance in mice.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Correction
Multidisciplinary Sciences
Yun Han Kwon, Suhrid Banskota, Huaqing Wang, Laura Rossi, Jensine A. Grondin, Saad A. Syed, Yeganeh Yousefi, Jonathan D. Schertzer, Katherine M. Morrison, Michael G. Wade, Alison C. Holloway, Michael G. Surette, Gregory R. Steinberg, Waliul I. Khan
NATURE COMMUNICATIONS
(2023)