Article
Engineering, Environmental
Ulkuye Dudu Gul, Zeynep Mine Senol, Burcu Ertit Tastan
Summary: The study found that the newly isolated and identified cyanobacterium Desertifilum tharense has high potential for removing food colorants, successfully removing 97% of the dye at optimal conditions. Detailed characterization of the biosorbent and examination of chlorophyll content were conducted.
WATER SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Tatsuya Dokoshi, Jason S. Seidman, Kellen J. Cavagnero, Fengwu Li, Marc C. Liggins, Bryn C. Taylor, Jocelyn Olvera, Rob Knight, John T. Chang, Nita H. Salzman, Richard L. Gallo
Summary: This study revealed that intestinal inflammation can promote the differentiation of intestinal stromal fibroblasts into preadipocytes with innate antimicrobial activity, and this process may be exacerbated by skin inflammation in mice. The activation of hyaluronan catabolism during skin injury was found to alter colon fibroblast function and promote excessive reactive adipogenesis, linking skin and colon inflammation through the release of hyaluronan.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Shmuel Avlas, Hala Kassis, Michal Itan, Hadar Reichman, Avishay Dolitzky, Inbal Hazut, Sharon Grisaru-Tal, Yaara Gordon, Ilan Tsarfaty, Danielle Karo-Atar, Perri Rozenberg, Almog Bitton, Ariel Munitz
Summary: Chronic inflammation is a characteristic feature of various inflammatory diseases, including inflammatory bowel disease (IBD). CD300 receptor family members have been shown to play important roles in innate immunity, as well as in allergic and autoimmune diseases. CD300b has been found to have a central and distinct role in colonic inflammation and subsequent repair, and it may be a future therapeutic target in inflammatory gastrointestinal (GI) diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jens Walldorf, Marc Porzner, Martin Neumann, Golsa Joodi, Jan Hendrik Niess, Georg von Boyen, Karsten Maeder, Julia Weissbach, Alexander Kleger, Thomas Seufferlein
Summary: The selective 5-HT1A receptor agonist SR57746A shows potential as a neuroprotective agent in the gastrointestinal tract, preventing apoptosis of intestinal epithelial cells and enteric glial cells, and reducing mucosal injury in inflammatory bowel disease models.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Chemistry, Analytical
Konstantin Pliuta, Alexander Chebotarev, Anastasia Pliuta, Denys Snigur
Summary: The study developed a modified carbon-paste electrode for the determination of Allura Red AC, with optimal detection conditions determined for square-wave voltammetric quantification. The calibration plot showed good linearity and the LOD and LOQ were also determined. The crafted sensor was successfully applied in model solutions and jelly candies analysis with RSD no more than 10%.
Article
Chemistry, Physical
Anahita Ramesh, Alireza Nezamzadeh-Ejhieh
Summary: A binary ZnO-PbS catalyst in nanoscale was characterized using various identification techniques. ZnO and ZnO-PbS showed synergistic photocatalytic activity, with the optimal activity achieved when the mole ratio of ZnO was four times greater than the other substances.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Physical
Oualid Hamdaoui, Slimane Merouani, Hadjer C. Benmahmoud, Meriem Ait Idir, Hamza Ferkous, Abdulaziz Alghyamah
Summary: In this study, the synergistic effect of ultrasound activation of chlorine for sonochemical treatment of hazardous organic materials was investigated. The degradation of a textile dye was significantly improved by the coupling of ultrasound and chlorine, resulting from the involvement of reactive chlorine species. The synergistic effect was influenced by the atmosphere, chlorine concentration, and pollutant concentration.
Article
Biochemistry & Molecular Biology
Yu Yu, Wenjing Yang, Anthony J. Bilotta, Xiaojing Zhao, Yingzi Cong, Yanqing Li
Summary: The study found that host-derived L-lactate can promote intestinal epithelial cell (IEC) migration by increasing mitochondrial ATP production in IEC, aiding in promoting intestinal wound healing. Additionally, administering mice with L-lactate can suppress colitis induced by dextran sulfate sodium.
Article
Chemistry, Analytical
Lawen Abdulsatar Esmail, Hijran Sanaan Jabbar
Summary: A sensitive method, ultrasound-assisted coupled dispersive nano solid-phase micro-extraction spectrophotometry, was designed for preconcentration and determination of the food colorant Allura Red AC in real samples. The method showed excellent linearity and high reusability.
MICROCHEMICAL JOURNAL
(2023)
Article
Environmental Sciences
Felipe Mejia-Otalvaro, Andres Merino-Restrepo, Angelina Hormaza-Anaguano
Summary: Synthetic dye bioremediation is important due to their toxicity and large quantities discharged into water bodies. Ligninolytic enzyme treatment, particularly laccase, has been shown to be cost-effective and achieve high decolorization levels. Immobilization of concentrated laccase extract can improve stability but may decrease dye decolorization efficiency.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Gastroenterology & Hepatology
Lijuan Wang, Ning Zhang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Ying Liu, Hanwen Zhang, Guohong Hu, Qifeng Yang
Summary: The study revealed that MTDH expression in colonic lamina propria macrophages is correlated with the severity of inflammatory colitis. MTDH-/- mice were protected against DSS-induced colitis, but adoptive transfer of MTDH wild-type monocytes partially restored susceptibility. TLR stimulation induced MTDH expression and absence of MTDH suppressed inflammatory cytokine production by macrophages.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Chemistry, Multidisciplinary
Konstantin Pliuta, Denys Snigur
Summary: In this paper, a method using adsorptive stripping voltammetry with a carbon paste electrode modified with beta-Cyclodextrin was used to determine Allura Red AC in soft drinks. The redox behavior of the dye was investigated and an oxidation mechanism was proposed. The proposed methodology and developed sensor showed good analytical performance and were successfully applied to soft drink analysis.
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Baher I. Salman
Summary: An innovative method using microwave-assisted nitrogen-doped carbon quantum dots (N@CQDs) was developed and validated for quantifying Allura red (AR, E129) dye in beverages. The method is based on the ion-pair association complex between AR and N@CQDs at pH 3.2, which leads to a quenching effect of N@CQDs fluorescence. The method showed a linear range of 0.07-10.0 µg mL(-1) with a regression coefficient of 0.9992. HR-TEM, XPS, Zeta potential measurements, and spectroscopic techniques were used to fully characterize the N@CQDs.
JOURNAL OF FLUORESCENCE
(2023)
Article
Medicine, Research & Experimental
Liyuan Mao, Fang Xin, Jie Ren, Shuai Xu, Haixia Huang, Xu Zha, Xinxin Wen, Guoqing Gu, Guang Yang, Yuan Cheng, Chen Zhang, Wei Wang, Xicheng Liu
Summary: This study demonstrates the dual functions of 5-HT/5-HT2B/TGF-beta signaling in the initiation and progression of colitis-associated cancer (CAC), with a critical role in tumor suppression but a promotion of cancer progression in the late-stage of CAC.
Review
Endocrinology & Metabolism
Brittany M. Duggan, Daniel M. Marko, Raveen Muzaffar, Darryl Y. Chan, Jonathan D. Schertzer
Summary: Small molecule kinase inhibitors (SMKIs) are therapeutic drugs that can target protein kinases and have effects on cell metabolism and endocrine control of organismal metabolism. They have been shown to improve blood glucose levels in diabetic cancer patients and reduce the dependence on insulin or diabetic medication.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Evangelia E. Tsakiridis, Marisa R. Morrow, Eric M. Desjardins, Dongdong Wang, Andrea Llanos, Bo Wang, Michael G. Wade, Katherine M. Morrison, Alison C. Holloway, Gregory R. Steinberg
Summary: Metabolic diseases are increasing worldwide and exposure to pesticides and pollutants may contribute to this trend. This study investigated the effects of the pesticide deltamethrin on metabolic disease development in mice fed a high-fat diet and housed at different temperatures. The results showed that low doses of deltamethrin improved metabolic parameters, while higher doses had no effect. Importantly, deltamethrin did not alter BAT thermogenesis markers or worsen obesity and insulin resistance in mice.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Health Care Sciences & Services
Claire N. Tugault-Lafleur, Olivia De-Jongh Gonzalez, Janice Macdonald, Jennifer Bradbury, Tom Warshawski, Geoff D. C. Ball, Katherine Morrison, Josephine Ho, Jill Hamilton, Annick Buchholz, Louise Masse
Summary: The study aimed to test the efficacy of the Aim2Be app with support from a live coach in reducing weight outcomes and improving lifestyle behaviors among adolescents with overweight and obesity. The results showed no significant differences in weight outcomes and health behaviors between the intervention and control groups at 3 months. However, among waitlist control participants, there were declines in weight outcomes and some health behaviors after receiving access to the app, and adolescents who used Aim2Be with live coaching reported more time being active outside of school compared to those without coaching.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Meeting Abstract
Physiology
Nazli Robin, Nicole Barra, Danish Patoli, Kevin Watt, Khang Nguyen, Kevin Foley, Yujin Li, Akhilesh Tamrakar, Irena Rebalka, Michael Huang, Rhianna Davis, Darryl Chan, Brittany Duggan, Brandyn Henriksbo, Paul Gregorevic, Gary Sweeney, Thomas Hawke, Benedicte Py, Jonathan Schertzer
Meeting Abstract
Physiology
Daniel Marko, Breanne McAlpin, Brittany Duggan, Joseph Cavallari, Jonathan Schertzer
Correction
Multidisciplinary Sciences
Yun Han Kwon, Suhrid Banskota, Huaqing Wang, Laura Rossi, Jensine A. Grondin, Saad A. Syed, Yeganeh Yousefi, Jonathan D. Schertzer, Katherine M. Morrison, Michael G. Wade, Alison C. Holloway, Michael G. Surette, Gregory R. Steinberg, Waliul I. Khan
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Alba Santiago, Amber Hann, Marco Constante, Sara Rahmani, Josie Libertucci, Kyle Jackson, Gaston Rueda, Laura Rossi, Ramachandran Rithwick, Wolfram Ruf, Jon Schertzer, Alberto Caminero, Premysl Bercik, Heather Jean Galipeau, Elena Francisca Verdu
Summary: Emerging evidence suggests that microbial proteolytic activity is implicated in ulcerative colitis (UC), but its role in Crohn's disease (CD) remains unclear. This study investigated the effects of colonizing germ-free mice with CD microbiota and healthy control microbiota. It was found that CD proteolytic microbiota increased colitis severity through a PAR2 pathway. These findings highlight the proinflammatory nature of CD proteolytic microbiota and its role in exacerbating colitis.
Article
Biochemistry & Molecular Biology
Suhrid Banskota, Huaqing Wang, Yun Han Kwon, Jaya Gautam, Sabah Haq, Jensine Grondin, Gregory R. Steinberg, Waliul I. Khan
Summary: Inhibiting NOX2 can alleviate colitis independently of AMPK, as shown by the study.
Article
Endocrinology & Metabolism
Fahd Alshammri, Hannah Geddie, Noor Sawalha, Gloria Kim, Karen Mcassey, Katherine M. Morrison
Summary: This study evaluated the adherence to lipid screening guidelines in a pediatric diabetes program and found that dyslipidemia is highly prevalent in pediatric diabetes patients, associated with obesity but also present in non-obese patients.
CANADIAN JOURNAL OF DIABETES
(2023)
Article
Rehabilitation
Madison L. Giles, Geoff D. C. Ball, Revi Bonder, Annick Buchholz, Jan Willem Gorter, Katherine M. Morrison, Arnaldo Perez, Meaghan Walker, Amy C. Mcpherson
Summary: This study aimed to explore the understanding of bodyweight, health and weight management among children with spina bifida (SB) and their parents, and identify appropriate services and supports for managing their health and weight. Using interpretive description and qualitative analysis, data were collected through individual interviews with children with SB (aged 10-18) and their parents attending Canadian SB clinics. The findings revealed that both children and parents had a weight-centric approach to health, viewing weight as under individual control, primarily through diet. Trusting relationships between healthcare providers, children and families were important in discussing weight.
DISABILITY AND REHABILITATION
(2023)
Article
Endocrinology & Metabolism
Mueez U-Din, Basma A. Ahmed, Saad A. Syed, Frank J. Ong, Stephan M. Oreskovich, Elizabeth Gunn, Michael G. Surette, Zubin Punthakee, Gregory R. Steinberg, Katherine M. Morrison
Summary: This study evaluated the triglyceride content of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), liver, kidneys, and pancreas in adult males and females. The results showed that VAT PDFF is related to impaired glucose homeostasis, dyslipidemia, and differences in the gut microbiome, independently of the total body fat percentage.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Tatiane A. Ribeiro, Jessica A. Breznik, Katherine M. A. Kennedy, Erica S. Yeo, Brianna K. E. J. Kennelly, Patrycja A. F. Jazwiec, Violet S. D. Patterson, Christian J. Bellissimo, Fernando F. M. Anhe, Jonathan D. Schertzer, Dawn M. E. Bowdish, Deborah M. Sloboda
Summary: This study found that pregnancy and diet have an impact on maternal intestinal structure and barrier function, as well as peripheral immunophenotype. High-fat diet can worsen the effects of pregnancy on the gut and immune system. Excess maternal adiposity can negatively influence both maternal and child health.