Article
Virology
Xunyan Ye, Obinna P. Iwuchukwu, Vasanthi Avadhanula, Letisha O. Aideyan, Trevor J. McBride, David M. Henke, Kirtida D. Patel, Felipe-Andres Piedra, Laura S. Angelo, Dimpy P. Shah, Roy F. Chemaly, Pedro A. Piedra
Summary: This study found that specific humoral and mucosal RSV antibodies play an important role in viral clearance in HCT recipients naturally infected with RSV, especially in the clearance of different RSV subtypes. The results of this study have implications for antigen selection in the development of RSV vaccines.
Article
Virology
Sebastien Barral, Aline Mamin, Carole Dantin, Stavroula Masouridi-Levrat, Yves Chalandon, Laurent Kaiser, Diem-Lan Vu
Summary: This retrospective observational study found that rhinovirus infections are the most common in allo-HSCT patients, including pre-transplant infections. However, the mortality rate due to pre-transplant RVIs is low.
Review
Immunology
Auke de Zwart, Annelies Riezebos-Brilman, Gerton Lunter, Judith Vonk, Allan R. Glanville, Jens Gottlieb, Nitipong Permpalung, Huib Kerstjens, Jan-Willem Alffenaar, Erik Verschuuren
Summary: In lung transplant recipients, RSV/PIV/hMPV infections are associated with a high incidence of chronic allograft dysfunction. However, current treatment options are limited. There is an urgent need for high-quality studies to provide better treatment options for these infections.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Virology
Roni Bitterman, Deepali Kumar
Summary: Solid organ transplantation comes with an increased risk of respiratory viral infections, especially problematic for lung transplant recipients. While influenza has treatment options, other respiratory viruses present treatment challenges. Novel antivirals, immunologic treatments, and vaccines are hoped for in the coming years to address this evolving area of concern.
Review
Microbiology
Michael Scolarici, Margaret Jorgenson, Christopher Saddler, Jeannina Smith
Summary: Invasive fungal infections (IFIs) are a serious complication of liver transplantation, with Candida, Aspergillus, and Cryptococcal infections being the most common. Prophylaxis is considered a promising mechanism for reducing the risks associated with these infections in liver transplant recipients.
Article
Immunology
Anja Gaeckler, Christoph Struve, Nils Muelling, Ute Eisenberger, Johannes Korth, Nina Babel, Andreas Kribben, Melanie Fiedler, Oliver Witzke, Hana Rohn
Summary: This study found that lymphocyte-depleting induction therapy and diabetes mellitus were independent risk factors for chronic NoV infection in kidney transplant patients. Chronic NoV infection resulted in prolonged hospital stays and impaired allograft function. Administration of IVIg seemed beneficial in alleviating clinical symptoms of NoV infection, although it had limited effects on viral shedding.
Article
Immunology
Vera Portillo, Stavroula Masouridi-Levrat, Lena Royston, Sabine Yerly, Manuel Schibler, Maria Mappoura, Sarah Morin, Federica Giannotti, Anne-Claire Mamez, Christian van Delden, Yves Chalandon, Dionysios Neofytos
Summary: Positive CMV serology in allogeneic hematopoietic cell transplant recipients (allo-HCTRs) may be false-positive due to transfusion-associated passive immunity. Reclassifying CMV status can help accurately assess the risk of CMV infection in these patients.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Emaan Haque, Ibrahim N. Muhsen, Walid Rasheed, Riad El Fakih, Mahmoud Aljurf
Summary: This review examines parasitic infections in hematopoietic stem cell transplantation (HSCT) recipients, focusing on major infections affecting different organ systems. Understanding the epidemiology, risk factors, and clinical presentations of these infections is crucial for timely intervention and successful management.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Biophysics
Micah Skeens, Parishma Guttoo, Joseph R. Stanek, Kimberly Taylor, Erica Stratz, Monica Ardura, Hemalatha G. Rangarajan
Summary: This study aimed to investigate COVID-19 vaccine hesitancy among parents of pediatric hematopoietic cell transplant (HCT) recipients and the impact of COVID-19 on their families. The majority of parents showed hesitancy towards the vaccine, and factors such as vaccine-related side effects, household factors, and education level were associated with the level of hesitancy.
BONE MARROW TRANSPLANTATION
(2022)
Article
Immunology
Xiaojing Zhang, Ruopeng Weng, Fei Liu, Yi Xie, Yanyan Jin, Qiuyu Li, Guoping Huang, Junyi Chen, Jingjing Wang, Huijun Shen, Haidong Fu, Jianhua Mao
Summary: This article evaluates the clinical protection provided by vaccines to kidney transplant recipients, including breakthrough infections, deaths, and hospitalizations. The study found that older age and a longer time interval from the last vaccine to COVID-19 infection were associated with lower hospitalization rates in kidney transplant recipients who received booster vaccines. Additionally, there were variations in breakthrough infection rates and associated deaths among different medical centers.
Article
Biophysics
Fevzi Altuntas, Naim Ata, Tugce Nur Yigenoglu, Semih Basci, Mehmet Sinan Dal, Serdal Korkmaz, Sinem Namdaroglu, Abdulkadir Basturk, Tuba Hacibekiroglu, Mehmet Hilmi Dogu, Ilhami Berber, Kursat Dal, Mehmet Ali Erkurt, Burhan Turgut, Mustafa Mahir Ulgu, Osman Celik, Abdullah Akunal, Suayip Birinci
Summary: This study reports the outcomes of COVID-19 in hematopoietic cell transplant recipients, showing a higher case fatality rate in these patients, particularly among those receiving immunosuppressive agents.
BONE MARROW TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Laura N. Walti, Catrina Mugglin, Matteo Mombelli, Oriol Manuel, Hans H. Hirsch, Nina Khanna, Nicolas J. Mueller, Christoph Berger, Katia Boggian, Christian Garzoni, Dionysios Neofytos, Christian van Delden, Mirjam Maeusezahl, Cedric Hirzel
Summary: This study found a higher incidence rate of vaccine-preventable infections in solid organ transplant recipients compared with the general population, with an increased risk for specific vaccine-preventable infections. The occurrence of vaccine-preventable infections was associated with an increased risk of death and graft loss in solid organ transplant recipients. Therefore, optimizing immunization strategies is highly important for this population.
Article
Oncology
Jessica R. Schwartz, Emily B. K. Thomas, Mark B. Juckett, Erin S. Costanzo
Summary: This study investigated posttraumatic growth (PTG) in cancer patients recovering from hematopoietic cell transplantation (HCT) and found that supportive social relationships and coping with difficult emotions may facilitate PTG. These factors were more important than medical characteristics in explaining PTG.
Review
Medicine, General & Internal
Anna Astashchanka, Joseph Ryan, Erica Lin, Brandon Nokes, Catriona Jamieson, Seth Kligerman, Atul Malhotra, Jess Mandel, Jisha Joshua
Summary: This review discusses the pulmonary complications post-HSCT, providing essential knowledge for non-pulmonary healthcare providers and emphasizing the importance of early diagnosis, treatment, and prognosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Chikara Ogimi, Emily T. Martin, Hu Xie, Angela P. Campbell, Alpana Waghmare, Keith R. Jerome, Wendy M. Leisenring, Filippo Milano, Janet A. Englund, Michael Boeckh
Summary: BoV respiratory tract infections in transplant recipients are rare and associated with mild symptoms. Risk factors for acquisition include younger age and exposure to children.
CLINICAL INFECTIOUS DISEASES
(2021)
