Article
Oncology
Xiao-Han Fan, Yang Zhang, Pei Wang, Qian-Qian Song, Mona Wang, Raquel Mejias-Luque, Zhe-Xuan Li, Tong Zhou, Jing-Ying Zhang, Wei-Dong Liu, Lan-Fu Zhang, Wen-Qing Li, Wei-Cheng You, Markus Gerhard, Yu-Chen Jiao, Xiao-Bing Wang, Kai-Feng Pan
Summary: This study explores noninvasive multianalytical biomarkers and constructs integrative models for risk assessment and gastric cancer (GC) screening. Methylation, mutation, and H. pylori-specific antibody panels were established and validated, and integrated models incorporating these biomarkers outperformed traditional models for risk assessment and GC detection. This study provides new insights for a more precise GC screening strategy in the future.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, Research & Experimental
Fabiola Lili Sarmiento-Salinas, Andrea Perez-Gonzalez, Adilene Acosta-Casique, Adrian Ix-Ballote, Alfonso Diaz, Samuel Trevino, Nora Hilda Rosas-Murrieta, Lourdes Millan-Perez-Pena, Paola Maycotte
Summary: Cancer is a major global cause of death, with the role of reactive oxygen species (ROS) in cancer development and progression being extensively studied. However, conflicting evidence exists regarding the specific impact of ROS on cancer, which may vary depending on the type of cancer and stage of tumorigenesis. Recent research has focused on exploring the diverse aspects of ROS interaction with cancer at different stages of cancer progression.
Article
Biochemistry & Molecular Biology
Ga-Eun Lee, Cheol-Jung Lee, Hyun-Jung An, Han Chang Kang, Hye Suk Lee, Joo Young Lee, Sei-Ryang Oh, Sung-Jun Cho, Dae Joon Kim, Yong-Yeon Cho
Summary: Fargesin inhibits cancer cell growth by suppressing cell cycle transition and EGF-induced cell transformation through multiple signaling pathways, including CDK/cyclin and Rb-E2F pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sydney R. Grant, Li Tang, Lei Wei, Barbara A. Foster, Gyorgy Paragh, Wendy J. Huss
Summary: More than 80,000 new cases of bladder cancer are estimated to be diagnosed in 2023, but the 5-year survival rate has remained unchanged for decades, highlighting the need for prevention. Mutations in cancer-driving genes in normal urothelium have shown a significant correlation with bladder cancer tissue, providing evidence for mutation hotspots in assessing cancer risk. A machine learning model using personal risk factors and mutations within bladder cancer hotspots has shown promising results in predicting high- vs. low-risk normal urothelium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Xiaohao Ruan, Da Huang, Jingyi Huang, James Hok-Leung Tsu, Rong Na
Summary: Genetic risk assessment for aggressive prostate cancer is challenging. In this study, a new polygenic risk score based on SNPs associated with prostate volume was developed and found to be able to predict the risk and mortality of aggressive prostate cancer. These findings provide a new genetic risk assessment method for the disease prognosis of prostate cancer patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Aria Baniahmad, Mohammad Taheri, Majid Samsami
Summary: NR2F1-AS1 is a natural antisense transcript that plays prominent roles in carcinogenesis. It acts as an oncogene in almost all types of cancers, except cervical and colorectal cancers. It functions as a molecular sponge for multiple miRNAs and affects the expression of cancer-related genes. Additionally, NR2F1-AS1 has an impact on several signaling pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Environmental Sciences
Mingming Xiao, Xinran Li, Xinlian Zhang, Xiaoxiao Duan, Houwei Lin, Sixiu Liu, Guodong Sui
Summary: Micro/nano plastics (MPs/NPs) derived from plastic products are a new type of environmental pollutants that can cause serious health issues. However, the molecular mechanisms of MPs/NPs toxicity remain unclear due to the lack of a physiologically relevant organ-organ linking platform in vitro. In this study, a kidney-testis microfluidic platform (KTP) was developed to simulate the state in vivo and assess the effects of MPs/NPs exposure on cancer-related signaling pathways. Results showed that MPs/NPs entered the kidney and testis via endocytosis and dysregulated proteins on cancer-related signaling pathways were identified.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Oncology
Ciara S. McNevin, Karen Cadoo, Anne-Marie Baird, Pierre Murchan, Orla Sheils, Ray McDermott, Stephen Finn
Summary: Studies have shown that prostate cancer patients with BRCA2/BRCA1 genetic aberrations are more likely to have worse disease and prognosis. BRCA2 mutation confers the highest risk for prostate cancer in men (8.6 fold in men & LE;65 years). While BRCA genes have garnered significant research attention, their role in the clinical assessment and treatment of prostate cancer remains complex.
Article
Oncology
Yuan Li, Zuhua Chen, Weiping Tao, Nan Sun, Jie He
Summary: TMS18, a novel tumor mutation score, was found to be more accurate and efficient in predicting response to immunotherapy in NSCLC compared to TMB. Combined with PD-L1, TMS18 showed improved accuracy and efficiency in predicting response to ICIs, suggesting its potential as a promising biomarker in larger cohorts.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Dorota Anusewicz, Magdalena Orzechowska, Andrzej K. Bednarek
Summary: The Notch signaling pathway regulates cell differentiation and is associated with carcinogenesis. Notch pathway members can be either oncogenic or suppressive depending on tissue context, showing promising potential for new treatment strategies.
Article
Oncology
Wenjing Zhang, Fuyan Shi, Yujia Kong, Yuting Li, Chao Sheng, Suzhen Wang, Qinghua Wang
Summary: Through integration of multiple studies, our research revealed a significant correlation between PTPRT mutations and the efficacy of ICI treatment in melanoma and NSCLC patients. Mutated patients showed better response rates and prolonged survival in immunotherapy, along with higher immune infiltration and mutation burden.
Article
Oncology
Wenbin Liu, Shiliang Cai, Rui Pu, Zixiong Li, Donghong Liu, Xinyu Zhou, Jianhua Yin, Xi Chen, Liping Chen, Jianfeng Wu, Xiaojie Tan, Xin Wang, Guangwen Cao
Summary: Mutations in the preS region of hepatitis B virus (HBV) are associated with an increased risk of hepatocellular carcinoma (HCC). In this study, several specific preS mutations were found to significantly increase the risk of HCC by promoting inflammation and altering gene expression in inflammation- and metabolism-related pathways. These findings highlight the importance of monitoring these mutations for HCC prevention.
Review
Cell Biology
Zeina Nehme, Natascha Roehlen, Punita Dhawan, Thomas F. F. Baumert
Summary: Tight junctions (TJs) are intercellular protein complexes that control paracellular permeability and cell polarity, and recent studies have shown their functional role beyond these classic functions. TJ proteins play crucial roles in cancer pathogenesis by modulating key signaling pathways that regulate cell proliferation, migration, and differentiation, as well as promoting stem cell phenotypes in cancer cells. Additionally, TJ proteins have been used as therapeutic targets and prognostic markers in preclinical and clinical studies. This review summarizes the functional role of TJ proteins in cancer biology and their potential for novel cancer prevention and treatment strategies.
Article
Oncology
Jiajia Song, Ling Bai, Jianzhao Zhai, Zhaodan Xin, Liting You, Yi Zhou, Juan Zhou, Binwu Ying
Summary: The frequency and proportion of ctDNA mutations are associated with therapeutic outcomes, and patients with lower mutation frequencies have better prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Jianfeng Zhou, Shangwei Sun, Siyuan Luan, Xin Xiao, Yushang Yang, Chengyi Mao, Longqi Chen, Xiaoxi Zeng, Yonggang Zhang, Yong Yuan
Summary: Esophageal cancer patients exhibit changes in their microbiota composition, which can serve as biomarkers for screening and prognosis, as well as be adjusted to treat cancer and reduce treatment adverse effects. These findings have important implications for clinical applications utilizing gut microbiota.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Meagan B. Myers, Malathi Banda, Karen L. Mckim, Yiying Wang, Michael J. Powell, Barbara L. Parsons
Article
Environmental Sciences
Mugimane G. Manjanatha, Sharon D. Shelton, Ying Chen, Barbara L. Parsons, Meagan B. Myers, Karen L. McKim, B. Bhaskar Gollapudi, Nigel P. Moore, Lynne T. Haber, Bruce Allen, Martha M. Moore
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2017)
Article
Environmental Sciences
Barbara L. Parsons, Karen L. McKim, Meagan B. Myers
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2017)
Article
Reproductive Biology
Ulrike Luderer, Meagan B. Myers, Malathi Banda, Karen L. Mckim, Laura Ortiz, Barbara L. Parsons
REPRODUCTIVE TOXICOLOGY
(2017)
Article
Cell & Tissue Engineering
Anna M. Nicholson, Cora Olpe, Alice Hoyle, Ann-Sofie Thorsen, Teja Rus, Mathilde Colombe, Roxanne Brunton-Sim, Richard Kemp, Kate Marks, Phil Quirke, Shalini Malhotra, Rogier ten Hoopen, Ashraf Ibrahim, Cecilia Lindskog, Meagan B. Myers, Barbara Parsons, Simon Tavare, Mark Wilkinson, Edward Morrissey, Douglas J. Winton
Article
Biochemistry & Molecular Biology
Meagan B. Myers, Karen L. McKim, Malathi Banda, Nysia I. George, Barbara L. Parsons
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Environmental Sciences
Kelly L. Harris, Vijay Walia, Binsheng Gong, Karen L. McKim, Meagan B. Myers, Joshua Xu, Barbara L. Parsons
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2020)
Article
Multidisciplinary Sciences
Malathi Banda, Karen L. McKim, Meagan B. Myers, Masahiro Inoue, Barbara L. Parsons
Article
Toxicology
Karen L. McKim, Meagan B. Myers, Kelly L. Harris, Binsheng Gong, Joshua Xu, Barbara L. Parsons
Summary: The study introduces a new method to predict neoplastic potential by analyzing DNA mutations in rodents. The findings suggest that this method can be used to anticipate future tumor development in mammary tissues.
TOXICOLOGICAL SCIENCES
(2021)
Article
Toxicology
Kelly L. Harris, Karen L. McKim, Meagan B. Myers, Binsheng Gong, Joshua Xu, Barbara L. Parsons
Summary: This study developed a new method to assess clonal expansion and predict future risk of cancer development. By studying mutations in enriched regions of amplicons in a mouse model, key genes related to lung cancer were identified. These findings may help in understanding the mechanisms of lung cancer development in humans.
TOXICOLOGICAL SCIENCES
(2021)