Isolation and Detection Technologies of Extracellular Vesicles and Application on Cancer Diagnostic

Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer

(2019) Xiaodan Wang et al.   MOLECULAR CARCINOGENESIS

Comparison of six commercial serum exosome isolation methods suitable for clinical laboratories. Effect in cytokine analysis

(2019) Mónica Macías et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

The potential role of exosomes derived from ovarian cancer cells for diagnostic and therapeutic approaches

(2019) Changwon Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tumor‐derived exosomal lncRNA GAS5 as a biomarker for early‐stage non‐small‐cell lung cancer diagnosis

(2019) Chuling Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ultrasensitive and Reversible Nanoplatform of Urinary Exosomes for Prostate Cancer Diagnosis

(2019) Ping Li et al.   ACS Sensors

c-Met and PD-L1 on Circulating Exosomes as Diagnostic and Prognostic Markers for Pancreatic Cancer

(2019) Alexander Lux et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rapid Isolation and Multiplexed Detection of Exosome Tumor Markers Via Queued Beads Combined with Quantum Dots in a Microarray

(2019) Yanan Bai et al.   Nano-Micro Letters

Integrated Analysis of Exosomal Protein Biomarkers on Alternating Current Electrokinetic Chips Enables Rapid Detection of Pancreatic Cancer in Patient Blood

(2018) Jean M. Lewis et al.   ACS Nano

Circulating miRNAs in blood and urine as diagnostic and prognostic biomarkers for bladder cancer: an update in 2017

(2018) Angelika Tölle et al.   Biomarkers in Medicine

An elevated expression of serum exosomal microRNA-191, − 21, −451a of pancreatic neoplasm is considered to be efficient diagnostic marker

(2018) Takuma Goto et al.   BMC CANCER

microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer

(2018) Divya Bhagirath et al.   CANCER RESEARCH

Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer

(2018) Haoyi Jin et al.   CANCER SCIENCE

Exosome-Based Detection ofEGFRT790M in Plasma from Non–Small Cell Lung Cancer Patients

(2018) Elena Castellanos-Rizaldos et al.   CLINICAL CANCER RESEARCH

Exosome enrichment by ultracentrifugation and size exclusion chromatography

(2018) Murray D Mitchell   Frontiers in Bioscience-Landmark

Plasma miRNAs in diagnosis and prognosis of pancreatic cancer: A miRNA expression analysis

(2018) Xin Zhou et al.   GENE

Breast cancer diagnosis: Imaging techniques and biochemical markers

(2018) Seyed Hamed Jafari et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Comparison of membrane affinity-based method with size-exclusion chromatography for isolation of exosome-like vesicles from human plasma

(2018) Ruzena Stranska et al.   Journal of Translational Medicine

Exosomes as a liquid biopsy for lung cancer

(2018) Shaohua Cui et al.   LUNG CANCER

Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme

(2018) Sze Kiat Tan et al.   Molecular Cancer

MicroRNA-10b expression in breast cancer and its clinical association

(2018) Jianhui Zhang et al.   PLoS One

An ultrasensitive polydopamine bi-functionalized SERS immunoassay for exosome-based diagnosis and classification of pancreatic cancer

(2018) Teng-Da Li et al.   Chemical Science

Advances of exosome in the development of ovarian cancer and its diagnostic and therapeutic prospect

(2018) Jiayu Shen et al.   OncoTargets and Therapy

Proteomic biomarkers in body fluids associated with pancreatic cancer

(2018) Cristina Jimenez-Luna et al.   Oncotarget

Exosomes in Cancer Liquid Biopsy: A Focus on Breast Cancer

(2018) Sina Halvaei et al.   Molecular Therapy-Nucleic Acids

Expression signatures of exosomal long non-coding RNAs in urine serve as novel non-invasive biomarkers for diagnosis and recurrence prediction of bladder cancer

(2018) Yao Zhan et al.   Molecular Cancer

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types

(2018) Masaki Kobayashi et al.   Journal of Ovarian Research

In Situ Detection of Plasma Exosomal MicroRNA-1246 for Breast Cancer Diagnostics by a Au Nanoflare Probe

(2018) Ling-Yan Zhai et al.   ACS Applied Materials & Interfaces

Isolation and Visible Detection of Tumor-Derived Exosomes from Plasma

(2018) Junge Chen et al.   ANALYTICAL CHEMISTRY

Tumor-derived exosomal proteins as diagnostic biomarkers in non-small cell lung cancer

(2018) Limin Niu et al.   CANCER SCIENCE

Evaluation of serum exosomal LncRNA-based biomarker panel for diagnosis and recurrence prediction of bladder cancer

(2018) Shujun Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Review on Electroporation-Based Intracellular Delivery

(2018) Junfeng Shi et al.   MOLECULES

Liquid biopsy in ovarian cancer: the potential of circulating miRNAs and exosomes

(2018) Lydia Giannopoulou et al.   Translational Research

Determination of Serum Exosomal H19 as a Noninvasive Biomarker for Bladder Cancer Diagnosis and Prognosis

(2018) Jiansong Wang et al.   MEDICAL SCIENCE MONITOR

Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid

(2018) Sara Busatto et al.   Cells

Extracellular vesicles as a source for non-invasive biomarkers in bladder cancer progression

(2017) Zoraida Andreu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Updated 2016 EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer

(2017) J. Alfred Witjes et al.   EUROPEAN UROLOGY

Silica nanostructured platform for affinity capture of tumor-derived exosomes

(2017) Parissa Ziaei et al.   JOURNAL OF MATERIALS SCIENCE

A microRNA signature from serum exosomes of patients with glioma as complementary diagnostic biomarker

(2017) Alessandra Santangelo et al.   JOURNAL OF NEURO-ONCOLOGY

Recent Changes in Prostate Cancer Screening Practices and Epidemiology

(2017) Daniel J. Lee et al.   JOURNAL OF UROLOGY

Serum exosomal miR-301a as a potential diagnostic and prognostic biomarker for human glioma

(2017) Fengming Lan et al.   CELLULAR ONCOLOGY

Clinical prospects of liquid biopsies

(2017) Catherine Alix-Panabières et al.   Nature Biomedical Engineering

Integrated Magneto–Electrochemical Sensor for Exosome Analysis

(2016) Sangmoo Jeong et al.   ACS Nano

Extracellular mRNA Detected by Tethered Lipoplex Nanoparticle Biochip for Lung Adenocarcinoma Detection

(2016) L. James Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Delivery of Nanoparticles for Treatment of Brain Tumor

(2016) Chen Kang et al.   CURRENT DRUG METABOLISM

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease

(2016) Laura Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation

(2016) Zhaogang Yang et al.   JOURNAL OF CONTROLLED RELEASE

Exosomal Proteins as Diagnostic Biomarkers in Lung Cancer

(2016) Birgitte Sandfeld-Paulsen et al.   Journal of Thoracic Oncology

Placental exosomes and pre-eclampsia: Maternal circulating levels in normal pregnancies and, early and late onset pre-eclamptic pregnancies

(2016) Preenan Pillay et al.   PLACENTA

High-throughput sequencing of two populations of extracellular vesicles provides an mRNA signature that can be detected in the circulation of breast cancer patients

(2016) Andrew Conley et al.   RNA Biology

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions

(2016) F. Pucci et al.   SCIENCE

Tumour-derived exosomes as a signature of pancreatic cancer - liquid biopsies as indicators of tumour progression

(2016) Zarin Nuzhat et al.   Oncotarget

Delivery System of CpG Oligodeoxynucleotides through Eliciting an Effective T cell Immune Response against Melanoma in Mice

(2016) Wei Sun et al.   Journal of Cancer

A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy

(2016) James McKiernan et al.   JAMA Oncology

Comparative Analysis of Technologies for Quantifying Extracellular Vesicles (EVs) in Clinical Cerebrospinal Fluids (CSF)

(2016) Johnny C. Akers et al.   PLoS One

Size Characterization and Quantification of Exosomes by Asymmetrical-Flow Field-Flow Fractionation

(2015) Simona Sitar et al.   ANALYTICAL CHEMISTRY

Association of TGF-β2 levels in breast milk with severity of breast biopsy diagnosis

(2015) Hannah P. Yang et al.   CANCER CAUSES & CONTROL

Fluorescence triggering: A general strategy for enumerating and phenotyping extracellular vesicles by flow cytometry

(2015) Nicolas Arraud et al.   CYTOMETRY PART A

Emerging circulating biomarkers in glioblastoma: promises and challenges

(2015) Mehdi Touat et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

(2015) Joel Z. Nordin et al.   Nanomedicine-Nanotechnology Biology and Medicine

Urinary microRNA-30a-5p is a potential biomarker for ovarian serous adenocarcinoma

(2015) JUN ZHOU et al.   ONCOLOGY REPORTS

Characterization of RNA from Exosomes and Other Extracellular Vesicles Isolated by a Novel Spin Column-Based Method

(2015) Daniel Enderle et al.   PLoS One

Exosomes: Novel Biomarkers for Clinical Diagnosis

(2015) Jin Lin et al.   TheScientificWorldJOURNAL

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

(2015) Huilin Shao et al.   Nature Communications

Exosomes: Novel Biomarkers for Clinical Diagnosis

(2015) Jin Lin et al.   Scientific World Journal

Commercial Cow Milk Contains Physically Stable Extracellular Vesicles Expressing Immunoregulatory TGF-β

(2015) Bartijn C. H. Pieters et al.   PLoS One

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Diagnostic and Prognostic Potential of Extracellular Vesicles in Peripheral Blood

(2014) Anne Louise Schacht Revenfeld et al.   CLINICAL THERAPEUTICS

Overdiagnosis and Overtreatment of Prostate Cancer

(2014) Stacy Loeb et al.   EUROPEAN UROLOGY

Toward routine detection of extracellular vesicles in clinical samples

(2014) R. van der Meel et al.   International Journal of Laboratory Hematology

Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology

(2014) Mei He et al.   LAB ON A CHIP

Detection of Tumor Cell-Specific mRNA and Protein in Exosome-Like Microvesicles from Blood and Saliva

(2014) Jieping Yang et al.   PLoS One

Exosomes: an overview of biogenesis, composition and role in ovarian cancer

(2014) Allison Beach et al.   Journal of Ovarian Research

Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes

(2014) Koji Ueda et al.   Scientific Reports

Specific Capture and Release of Circulating Tumor Cells Using Aptamer-Modified Nanosubstrates

(2013) Qinglin Shen et al.   ADVANCED MATERIALS

Characterization of human plasma-derived exosomal RNAs by deep sequencing

(2013) Xiaoyi Huang et al.   BMC GENOMICS

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

(2013) Asfar S. Azmi et al.   CANCER AND METASTASIS REVIEWS

Comparison of serum exosome isolation methods for microRNA profiling

(2013) Kadri Rekker et al.   CLINICAL BIOCHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

A direct extraction method for microRNAs from exosomes captured by immunoaffinity beads

(2012) Chang Eun Yoo et al.   ANALYTICAL BIOCHEMISTRY

Changes in circulating microRNA levels associated with prostate cancer

(2012) R J Bryant et al.   BRITISH JOURNAL OF CANCER

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

(2012) C. D'Souza-Schorey et al.   GENES & DEVELOPMENT

Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers

(2012) M. Lucrecia Alvarez et al.   KIDNEY INTERNATIONAL

Microfluidic filtration system to isolate extracellular vesicles from blood

(2012) Ryan T. Davies et al.   LAB ON A CHIP

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

(2012) Bow J. Tauro et al.   METHODS

Breast cancer

(2012) Michelle Grayson   NATURE

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

(2012) Huilin Shao et al.   NATURE MEDICINE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

Magnetic Nanoparticles and microNMR for Diagnostic Applications

(2012) Huilin Shao et al.   Theranostics

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

(2011) Viktoriya Sokolova et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation

(2011) Frederik J Verweij et al.   EMBO JOURNAL

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Structural-Mechanical Characterization of Nanoparticle Exosomes in Human Saliva, Using Correlative AFM, FESEM, and Force Spectroscopy

(2010) Shivani Sharma et al.   ACS Nano

Endosome–lysosome fusion: Figure 1

(2010) J. Paul Luzio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer

(2010) L M Flores et al.   BRITISH JOURNAL OF CANCER

CA 15-3: Uses and limitation as a biomarker for breast cancer

(2010) Michael J. Duffy et al.   CLINICA CHIMICA ACTA

Flow cytometric analysis of circulating microparticles in plasma

(2010) Aaron F. Orozco et al.   CYTOMETRY PART A

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Proteomics Analysis of Bladder Cancer Exosomes

(2010) Joanne L. Welton et al.   MOLECULAR & CELLULAR PROTEOMICS

Membrane budding and scission by the ESCRT machinery: it's all in the neck

(2010) James H. Hurley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery

(2010) Francesca Raimondo et al.   PROTEOMICS

Novel test for microparticles in platelet-rich plasma and platelet concentrates using dynamic light scattering

(2010) Yan Xu et al.   TRANSFUSION

Microfluidic isolation and transcriptome analysis of serum microvesicles

(2009) Chihchen Chen et al.   LAB ON A CHIP

High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients

(2009) Mariantonia Logozzi et al.   PLoS One

Detergent binding explains anomalous SDS-PAGE migration of membrane proteins

(2009) Arianna Rath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microparticle sizing by dynamic light scattering in fresh-frozen plasma

(2009) A. S. Lawrie et al.   VOX SANGUINIS

Proteomic and immunologic analyses of brain tumor exosomes

(2008) Michael W. Graner et al.   FASEB JOURNAL

Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes

(2008) Juha Hakulinen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY