Article
Oncology
Junfeng Qiu, Mingzhou Li, Cailin Su, Yihao Liang, Ruizhang Ou, Xiaoning Chen, Chengmei Huang, Yaxin Zhang, Yaping Ye, Wenting Liao, Chao Zhang
Summary: This study found that in colorectal cancer (CRC), the expression of FOXS1 is upregulated and is positively correlated with poor survival. FOXS1 promotes malignant behavior of CRC cells, including proliferation, invasion, and angiogenesis, both in vitro and in vivo. Mechanistically, FOXS1 upregulates the transcriptional level of CXCL8 to regulate tumor growth and metastasis. These findings suggest that the FOXS1/CXCL8 axis may serve as a potential therapeutic target for the treatment of metastatic CRC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Daniel Brock Hewitt, Zachary J. Brown, Timothy M. Pawlik
Summary: Colorectal cancer liver metastasis is a common and serious condition worldwide. Various treatment methods exist, but reliable biomarkers are limited. Recent advancements in genomic sequencing technology have improved our understanding of the mechanisms of colorectal cancer, and reduced the cost and time of investigations. This article discusses the current utility of biomarkers in managing colorectal cancer liver metastasis.
Article
Oncology
Elzbieta Pawluczuk, Marta Lukaszewicz-Zajac, Mariusz Gryko, Agnieszka Kulczynska-Przybik, Barbara Mroczko
Summary: The study suggests that serum CXCL8 and CXCR2 concentrations are significantly higher in gastric cancer patients compared to healthy controls, with CXCL8 showing the highest diagnostic sensitivity among all tested proteins. Serum CXCL8 levels are indicated as a significant risk factor for gastric cancer occurrence and are a promising candidate for a biomarker in gastric cancer diagnosis.
Review
Oncology
Raghav Chandra, John D. Karalis, Charles Liu, Gilbert Z. Murimwa, Josiah Voth Park, Christopher A. Heid, Scott I. Reznik, Emina Huang, John D. Minna, Rolf A. Brekken
Summary: Colorectal cancer (CRC) ranks as the third most common malignancy globally and the second leading cause of cancer-related deaths. The cellular components of the tumor microenvironment (TME) play crucial roles in tumor engraftment and metastasis to distant organs such as the liver and lungs.
Review
Oncology
Tarak Chouari, Nabeel Merali, Francesca La Costa, Jonas Santol, Shelley Chapman, Alex Horton, Somaiah Aroori, John Connell, Timothy A. Rockall, Damian Mole, Patrick Starlinger, Fenella Welsh, Myrddin Rees, Adam E. Frampton
Summary: This narrative review summarises the current limited literature on the use of LiverMultiScan (TM) software for non-invasive assessment of liver health. The review examines the evidence for its use in chronic liver disease, liver malignancy, and perioperative planning, and explores its potential applications and challenges in liver surgery. The software offers an attractive non-invasive method for assessing liver histopathology, especially in the context of colorectal liver metastasis, and may have future applications in other hepatic malignancies.
Article
Medicine, Research & Experimental
Ambre Giguelay, Evgenia Turtoi, Lakhdar Khelaf, Guillaume Tosato, Ikrame Dadi, Tommy Chastel, Marie-Alix Poul, Marine Pratlong, Stefan Nicolescu, Dany Severac, Antoine Adenis, Olivia Sgarbura-Popescu, Sebastien Carrere, Philippe Rouanet, Marc Ychou, Francois Quenet, Didier Pourqier, Pierre-Emmanuel Colombo, Andrei Turtoi, Jacques Colinge
Summary: This study confirms the heterogeneity of CRC-LM CAFs through single-cell transcriptomic analysis and proposes a model for recruiting different origins of CAFs to the liver in different liver malignancies. Additionally, the study finds that targeting LTBP2 with antibodies may help deplete ECM-remodeling CAFs in CRC-LMs.
Review
Medicine, General & Internal
Dimitrios K. Filippiadis, Georgios Velonakis, Alexis Kelekis, Constantinos T. Sofocleous
Summary: Approximately 50% of colorectal cancer patients will develop metastases during the course of the disease. Local or locoregional therapies for the treatment of liver metastases are used in the management of oligometastatic colorectal liver disease, especially in nonsurgical candidates. Thermal ablation (TA) is recommended in the treatment of limited liver metastases as free-standing therapy or in combination with surgery as long as all visible disease can be eradicated.
Review
Oncology
S. Acciuffi, F. Meyer, A. Bauschke, R. Croner, U. Settmacher, A. Altendorf-Hofmann
Summary: The treatment of patients with solitary colorectal liver metastasis involves various surgical options including liver resection and local ablation, as well as multidisciplinary techniques. Identifying prognostic factors is crucial in determining the treatment strategy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Manlio Tolomeo, Andrea Cavalli, Antonio Cascio
Summary: STAT1 protein plays a crucial role in the immune response against viruses, and its deficiency can result in severe infections and even death. It has been found that some viruses inhibit the activity of STAT1, making it important to search for drugs that can target these viral proteins for the treatment of dangerous viral infections and future viral pandemics, as demonstrated by the clinical results with Paxlovid in SARS-CoV-2-infected patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jinbing Sun, Zhihua Lu, Wei Fu, Kuangyi Lu, Xiuwen Gu, Feng Xu, Jiamin Dai, Yang Yang, Jianlong Jiang
Summary: Exosomes derived from cancer cells, particularly those containing elevated levels of ADAM17, play a role in promoting the migratory ability of colorectal cancer cells by cleaving E-cadherin junctions. This finding suggests that exosomal ADAM17 may serve as a blood-based biomarker for colorectal cancer metastasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Costanza Ballaro, Valeria Quaranta, Gianluigi Giannelli
Summary: Colorectal cancer is a common malignancy with a high mortality rate, mainly caused by colorectal liver metastasis. Communication between cancer cells and the environment plays a crucial role in creating a favorable tumor microenvironment, and this communication is mediated by soluble molecules such as cytokines. This review highlights the involvement of various cytokines in the development of colorectal liver metastases and emphasizes the complex nature of the cytokine milieu and its therapeutic implications.
Review
Cell Biology
Lavanya Goodla, Xiang Xue
Summary: This brief review discusses the involvement of three representative cytokines (TNF-alpha, IL-6 and IL-1 beta), a lipid molecule PGE2 and two chemokines (CXCL1 and CXCL2) in the process of CRC liver metastases.
Article
Cell Biology
Yuqiu Xu, Zhuang Wei, Mei Feng, Dexiang Zhu, Shenglin Mei, Zhongen Wu, Qingyang Feng, Wenju Chang, Meiling Ji, Chenglong Liu, Yuanyuan Zhu, Lian Shen, Fan Yang, Yijiao Chen, Yuxiong Feng, Jianmin Xu, Di Zhu
Summary: This study used single-cell RNA sequencing to investigate the immune cells involved in colorectal cancer liver metastasis. The researchers found that activated B cells were significantly depleted in patients with liver metastasis. They also identified a subtype of B cells called immature plasma cell alpha that was highly correlated with metastasis. Inhibition of the Wnt and TGF-0 pathways in cancer cells promoted the migration of activated B cells. These findings highlight the importance of B cell subpopulations in colorectal cancer liver metastasis and suggest potential strategies for drug development and management.
Review
Oncology
Ming Yang, Chunye Zhang
Summary: Liver sinusoidal endothelial cells (LSECs) play critical roles in liver physiology and pathology, with their altered state affecting the progression of liver diseases, including hepatocellular carcinoma. Targeting LSECs as a treatment strategy holds potential for preventing cancer liver metastasis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Hang He, Shuman Zhang, Hai Yang, Pengyan Xu, Isabella Kutschick, Susanne Pfeffer, Nathalie Britzen-Laurent, Robert Gruetzmann, Deliang Fu, Christian Pilarsky
Summary: This study identified PCSK6 as a critical gene involved in liver metastasis in pancreatic cancer and investigated its biological functions and molecular mechanisms using CRISPR/Cas9 technology. It was found that inactivation of PCSK6 could efficiently suppress liver metastasis, suggesting its potential as a novel therapeutic target for liver metastasis in pancreatic cancer.
