The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors

Paf1C regulates RNA polymerase II progression by modulating elongation rate

(2019) Liming Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Born to run: control of transcription elongation by RNA polymerase II

(2018) Fei Xavier Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of paused transcription complex Pol II–DSIF–NELF

(2018) Seychelle M. Vos et al.   NATURE

Structure of activated transcription complex Pol II–DSIF–PAF–SPT6

(2018) Seychelle M. Vos et al.   NATURE

Trunk neural crest cells: formation, migration and beyond

(2017) Guillermo A. Vega-Lopez et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

PAF1 complex component Leo1 helps recruitDrosophilaMyc to promoters

(2017) Jennifer M. Gerlach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAF1 regulation of promoter-proximal pause release via enhancer activation

(2017) Fei Xavier Chen et al.   SCIENCE

Transcription pausing regulates mouse embryonic stem cell differentiation

(2017) Melodi Tastemel et al.   Stem Cell Research

Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation

(2017) S. Branden Van Oss et al.   TRENDS IN BIOCHEMICAL SCIENCES

RNA polymerase II pausing modulates hematopoietic stem cell emergence in zebrafish

(2016) Q. Yang et al.   BLOOD

The positive transcriptional elongation factor (P-TEFb) is required for neural crest specification

(2016) Victoria L. Hatch et al.   DEVELOPMENTAL BIOLOGY

The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6

(2016) S. Branden Van Oss et al.   MOLECULAR CELL

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a

(2016) Alexandros Strikoudis et al.   NATURE CELL BIOLOGY

Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II

(2016) Xiaodong Lu et al.   NUCLEIC ACIDS RESEARCH

Ctr9, a Key Component of the Paf1 Complex Affects Proliferation and Terminal Differentiation in the Developing Drosophila Nervous System

(2016) S. Bahrampour et al.   G3-Genes Genomes Genetics

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II

(2015) Fei Xavier Chen et al.   CELL

Establishing neural crest identity: a gene regulatory recipe

(2015) M. Simoes-Costa et al.   DEVELOPMENT

RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II

(2015) M. Yu et al.   SCIENCE

RNA polymerase II pausing during development

(2014) B. Gaertner et al.   DEVELOPMENT

Stable Pausing by RNA Polymerase II Provides an Opportunity to Target and Integrate Regulatory Signals

(2013) Telmo Henriques et al.   MOLECULAR CELL

RNA Polymerase II Elongation Control

(2012) Qiang Zhou et al.   Annual Review of Biochemistry

Antagonistic Regulation of PAF1C and p-TEFb Is Required for Oligodendrocyte Differentiation

(2012) S. Kim et al.   JOURNAL OF NEUROSCIENCE

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

Simple Methods for Generating and Detecting Locus-Specific Mutations Induced with TALENs in the Zebrafish Genome

(2012) Timothy J. Dahlem et al.   PLoS Genetics

Paused RNA Polymerase II as a Developmental Checkpoint

(2011) Michael Levine   CELL

The PAF1 complex differentially regulates cardiomyocyte specification

(2011) Adam D. Langenbacher et al.   DEVELOPMENTAL BIOLOGY

Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population

(2011) Wen-Der Wang et al.   DEVELOPMENTAL BIOLOGY

Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells

(2011) I. M. Min et al.   GENES & DEVELOPMENT

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

The Paf1 complex: Platform or player in RNA polymerase II transcription?

(2010) Judith A. Jaehning   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation

(2010) Sergei Nechaev et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis

(2010) Andrew G. Muntean et al.   CANCER CELL

TIF1γ Controls Erythroid Cell Fate by Regulating Transcription Elongation

(2010) Xiaoying Bai et al.   CELL

The Human PAF1 Complex Acts in Chromatin Transcription Elongation Both Independently and Cooperatively with SII/TFIIS

(2010) Jaehoon Kim et al.   CELL

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish

(2010) Catherine T. Nguyen et al.   DEVELOPMENTAL BIOLOGY

SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo

(2010) M. J. Jurynec et al.   Disease Models & Mechanisms

A Genome-Scale RNAi Screen for Oct4 Modulators Defines a Role of the Paf1 Complex for Embryonic Stem Cell Identity

(2009) Li Ding et al.   Cell Stem Cell

Genetic ablation of neural crest cell diversification

(2009) B. L. Arduini et al.   DEVELOPMENT

DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation

(2009) Y. Chen et al.   GENES & DEVELOPMENT

The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control

(2009) Christian Mosimann et al.   MECHANISMS OF DEVELOPMENT

Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling

(2009) K. Adelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3′ mRNA processing factors

(2009) Orit Rozenblatt-Rosen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronous and Stochastic Patterns of Gene Activation in theDrosophilaEmbryo

(2009) Alistair N. Boettiger et al.   SCIENCE

RNA Polymerase II-Association Factor 1 (Paf1/PD2) Maintains Self-renewal by Its Interaction with Oct3/4 in Mouse Embryonic Stem Cells

(2009) Moorthy P. Ponnusamy et al.   STEM CELLS

Pathfinding in a large vertebrate axon tract: isotypic interactions guide retinotectal axons at multiple choice points

(2008) A. J. Pittman et al.   DEVELOPMENT

Direct Interactions between the Paf1 Complex and a Cleavage and Polyadenylation Factor Are Revealed by Dissociation of Paf1 from RNA Polymerase II

(2008) Kristen Nordick et al.   EUKARYOTIC CELL

Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle

(2008) M. J. Jurynec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA