Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 44, Pages E9224-E9232Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1705816114
Keywords
Drosophila; Myc; transcription; growth; PAF1
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Funding
- German Research Foundation [WO 2108/1-1, GA 1553/1-1, GA 1553/2-1]
- Swiss National Science Foundation [3100A0-120458/1]
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The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc's binding to its transcriptional targets. Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the PAF1 complex is typically associated with active genes, this interaction with Leo1 contributes to Myc targeting to open promoters.
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