Protozoan Parasites Glycosylphosphatidylinositol Anchors: Structures, Functions and Trends for Drug Discovery

The role of GlcNAc-PI-de-N-acetylase gene by gene knockout through homologous recombination and its consequences on survival, growth and infectivity of Leishmania major in in vitro and in vivo conditions

(2016) Pooya Ghasemi Nejad Almani et al.   ACTA TROPICA

In silico drug re-purposing against African sleeping sickness using GlcNAc-PI de- N -acetylase as an experimental target

(2015) Mayank Rashmi et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Molecular dynamics simulations and statistical coupling analysis of GPI12 in L. major: functional co-evolution and conservedness reveals potential drug–target sites

(2015) Shailza Singh et al.   Molecular BioSystems

Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates

(2015) Yari Cabezas et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Leishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?

(2015) Claire-Lise Forestier et al.   Frontiers in Cellular and Infection Microbiology

Molecular modeling and molecular dynamics simulations of GPI 14 in Leishmania major: Insight into the catalytic site for active site directed drug design

(2014) Sonali Shinde et al.   JOURNAL OF THEORETICAL BIOLOGY

Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

(2014) Amy S. Capes et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Virulent and Avirulent Strains of Toxoplasma gondii Which Differ in Their Glycosylphosphatidylinositol Content Induce Similar Biological Functions in Macrophages

(2014) Sebastian Niehus et al.   PLoS One

Recent progress in synthetic and biological studies of GPI anchors and GPI-anchored proteins

(2013) Shichong Yu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Lipid synthesis in protozoan parasites: A comparison between kinetoplastids and apicomplexans

(2013) Srinivasan Ramakrishnan et al.   PROGRESS IN LIPID RESEARCH

Identification and Functional Analysis of Trypanosoma cruzi Genes That Encode Proteins of the Glycosylphosphatidylinositol Biosynthetic Pathway

(2013) Mariana S. Cardoso et al.   PLoS Neglected Tropical Diseases

Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

(2012) Catherine A. McLellan et al.   ACS Chemical Biology

Chemical Biology of Glycosylphosphatidylinositol Anchors

(2012) Yu-Hsuan Tsai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

(2012) S Wein et al.   BRITISH JOURNAL OF PHARMACOLOGY

Leishmania virulence factors: focus on the metalloprotease GP63

(2012) Martin Olivier et al.   MICROBES AND INFECTION

Glycosylphosphatidylinositols of Protozoan Parasites

(2012) Yu-Hsuan Tsai et al.   TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY

Efficacy of Oral E1210, a New Broad-Spectrum Antifungal with a Novel Mechanism of Action, in Murine Models of Candidiasis, Aspergillosis, and Fusariosis

(2011) Katsura Hata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthetic neoglycoconjugates of cell-surface phosphoglycans of Leishmania as potential anti-parasite carbohydrate vaccines

(2011) A. V. Nikolaev et al.   BIOCHEMISTRY-MOSCOW

Inhibitors Incorporating Zinc-Binding Groups Target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the Causative Agent of African Sleeping Sickness

(2011) Nuha Z. Abdelwahab et al.   Chemical Biology & Drug Design

PG12, a Phospholipid Analog with Potent Antimalarial Activity, InhibitsPlasmodium falciparumCTP:Phosphocholine Cytidylyltransferase Activity

(2011) Patricia González-Bulnes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic glycosylphosphatidylinositol (GPI) anchors: how these complex molecules have been made

(2011) Andrei V. Nikolaev et al.   NATURAL PRODUCT REPORTS

Structure, functions, and biosynthesis of glycoconjugates of Leishmania spp. cell surface

(2010) N. M. Novozhilova et al.   BIOCHEMISTRY-MOSCOW

Glycobiology of theLeishmaniaparasite and emerging targets for antileishmanial drug discovery

(2010) Sunandini Chandra et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Symmetrical choline-derived dications display strong anti-kinetoplastid activity

(2010) Hasan M. S. Ibrahim et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Trypanosome Glycosylphosphatidylinositol Biosynthesis

(2009) Yeonchul Hong et al.   KOREAN JOURNAL OF PARASITOLOGY

Probing Enzymes Late in the Trypanosomal Glycosylphosphatidylinositol Biosynthetic Pathway with Synthetic Glycosylphosphatidylinositol Analogues

(2008) Michael D. Urbaniak et al.   ACS Chemical Biology

Synthesis of 1-d-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-α-d-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

(2008) Arthur T. Crossman et al.   CARBOHYDRATE RESEARCH

Chemical Structure of Major Glycoconjugates from Parasites

(2008) Lucia Mendonca-Previato et al.   CURRENT ORGANIC CHEMISTRY