Altered HDL metabolism in metabolic disorders: insights into the therapeutic potential of HDL

Obesity-induced overexpression of miRNA-24 regulates cholesterol uptake and lipid metabolism by targeting SR-B1

(2018) Meina Wang et al.   GENE

Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-Controlled Type 2 Diabetes

(2017) Sangeeta R Kashyap et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium

(2017) Mario Ruiz et al.   Lipids in Health and Disease

Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease

(2017) A. Michael Lincoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired HDL2-mediated cholesterol efflux is associated with metabolic syndrome in families with early onset coronary heart disease and low HDL-cholesterol level

(2017) Timo Paavola et al.   PLoS One

Apolipoprotein A-I exchange is impaired in metabolic syndrome patients asymptomatic for diabetes and cardiovascular disease

(2017) Mark S. Borja et al.   PLoS One

Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell ProtectionSignificance

(2016) Jonas W. Brinck et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A novel anti-inflammatory mechanism of high density lipoprotein through up-regulating annexin A1 in vascular endothelial cells

(2016) Bing Pan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity

(2016) Bruno Vergès et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

HDL in diabetic nephropathy has less effect in endothelial repairing than diabetes without complications

(2016) Yufeng Li et al.   Lipids in Health and Disease

Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution

(2016) Nicholas J. Woudberg et al.   Lipids in Health and Disease

Insulin Resistance in Relation to Lipids and Inflammation in Type-2 Diabetic Patients and Non-Diabetic People

(2016) Ying-Mei Feng et al.   PLoS One

Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: “Herniated” HDL, a common feature in diabetes

(2016) Núria Amigó et al.   Scientific Reports

Impaired HDL cholesterol efflux in metabolic syndrome is unrelated to glucose tolerance status: the CODAM study

(2016) Wijtske Annema et al.   Scientific Reports

Oxidized High-Density Lipoprotein Impairs Endothelial Progenitor Cells' Function by Activation of CD36-MAPK-TSP-1 Pathways

(2015) Jianxiang Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Remarkable quantitative and qualitative differences in HDL after niacin or fenofibrate therapy in type 2 diabetic patients

(2015) Luís Masana et al.   ATHEROSCLEROSIS

Increased cholesterol efflux capacity in metabolic syndrome: Relation with qualitative alterations in HDL and LCAT

(2015) Diego Lucero et al.   ATHEROSCLEROSIS

Rapid and Body Weight-Independent Improvement of Endothelial and High-Density Lipoprotein Function After Roux-en-Y Gastric Bypass: Role of Glucagon-Like Peptide-1

(2015) E. Osto et al.   CIRCULATION

Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In VivoNovelty and Significance

(2015) Nicole Urtz et al.   CIRCULATION RESEARCH

Myeloperoxidase-mediated oxidation targets serum apolipoprotein A-I in diabetic patients and represents a potential mechanism leading to impaired anti-apoptotic activity of high density lipoprotein

(2015) Naihao Lu et al.   CLINICA CHIMICA ACTA

Increasing HDL levels by inhibiting cholesteryl ester transfer protein activity in rabbits with hindlimb ischemia is associated with increased angiogenesis

(2015) Ben J. Wu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

In Type 2 Diabetes Mellitus Glycated Albumin Alters Macrophage Gene Expression Impairing ABCA1-Mediated Cholesterol Efflux

(2015) Adriana Machado-Lima et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Glycoxidized HDL, HDL Enriched With Oxidized Phospholipids and HDL From Diabetic Patients Inhibit Platelet Function

(2015) Quang Huy Lê et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Excess Mortality among Persons with Type 2 Diabetes

(2015) Mauro Tancredi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fenofibrate and extended-release niacin improve the endothelial protective effects of HDL in patients with metabolic syndrome

(2015) Monica Gomaraschi et al.   VASCULAR PHARMACOLOGY

HDL and CER-001 Inverse-Dose Dependent Inhibition of Atherosclerotic Plaque Formation in apoE-/- Mice: Evidence of ABCA1 Down-Regulation

(2015) Claudine Tardy et al.   PLoS One

Insulin-induced glucose control improves HDL cholesterol levels but not reverse cholesterol transport in type 2 diabetic patients

(2014) Gian Paolo Fadini et al.   ATHEROSCLEROSIS

Relationships between obesity, glycemic control, and cardiovascular risk factors: a pooled analysis of cross-sectional data from Spanish patients with type 2 diabetes in the preinsulin stage

(2014) Luis A Vázquez et al.   BMC Cardiovascular Disorders

The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus

(2014) Xunliang Tong et al.   Cardiovascular Diabetology

Glycation of Apolipoprotein C1 Impairs Its CETP Inhibitory Property: Pathophysiological Relevance in Patients With Type 1 and Type 2 Diabetes

(2014) Benjamin Bouillet et al.   DIABETES CARE

Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial

(2014) J.-C. Tardif et al.   EUROPEAN HEART JOURNAL

Anacetrapib and dalcetrapib differentially alters HDL metabolism and macrophage-to-feces reverse cholesterol transport at similar levels of CETP inhibition in hamsters

(2014) François Briand et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interrelationships Between the Kinetics of VLDL Subspecies and HDL Catabolism in Abdominal Obesity: A Multicenter Tracer Kinetic Study

(2014) Bruno Vergès et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effects of bariatric surgery on HDL structure and functionality: results from a prospective trial

(2014) Evangelia Zvintzou et al.   Journal of Clinical Lipidology

Enhanced cholesterol efflux to HDL through the ABCA1 transporter in hypertriglyceridemia of type 2 diabetes

(2014) Hussein N. Yassine et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Adiposity measurements in association with metabolic syndrome in older men have different clinical implications

(2014) Chun-Hsien Hsu et al.   NUTRITION RESEARCH

Paraoxonase responses to exercise and niacin therapy in men with metabolic syndrome

(2014) James Kyle Taylor et al.   REDOX REPORT

Novel Formulation of a Reconstituted High-Density Lipoprotein (CSL112) Dramatically Enhances ABCA1-Dependent Cholesterol Efflux

(2013) Svetlana Diditchenko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice

(2013) Claudine Tardy et al.   ATHEROSCLEROSIS

Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease

(2013) Meliana Riwanto et al.   CIRCULATION

Deleterious effect of glycation on the ability of HDL to counteract the inhibitory effect of oxidized LDL on endothelium-dependent vasorelaxation

(2013) M. C. Brindisi et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair

(2013) Bing Pan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apolipoprotein A-I glycation by Glucose and Reactive Aldehydes Alters Phospholipid Affinity but Not Cholesterol Export from Lipid-Laden Macrophages

(2013) Bronwyn E. Brown et al.   PLoS One

Inhibition of cholesteryl ester transfer protein by anacetrapib does not impair the anti-inflammatory properties of high density lipoprotein

(2012) Seongah Han et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Reduction of paraoxonase-1 activity may contribute the qualitative impairment of HDL particles in patients with type 2 diabetes

(2012) Hiroshi Murakami et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models

(2012) H. Low et al.   DIABETOLOGIA

Nitric oxide and pro-inflammatory cytokine serum levels in postmenopausal women with the metabolic syndrome

(2012) Peter Chedraui et al.   GYNECOLOGICAL ENDOCRINOLOGY

Effect of weight loss, independent of change in diet composition, on apolipoprotein AI kinetic in men with metabolic syndrome

(2012) Caroline Richard et al.   JOURNAL OF LIPID RESEARCH

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Evaluation of Oxidative Stress in Overweight Subjects With or Without Metabolic Syndrome

(2012) Danielle Venturini et al.   Obesity

Management of Dyslipidemias in the Presence of the Metabolic Syndrome or Type 2 Diabetes

(2012) Niina Matikainen et al.   Current Cardiology Reports

High-Density Lipoprotein Cholesterol Efflux, Nitration of Apolipoprotein A-I, and Endothelial Function in Obese Women

(2011) Edward Vazquez et al.   AMERICAN JOURNAL OF CARDIOLOGY

Lower Serum Paraoxonase-1 Activity Is Related to Higher Serum Amyloid A Levels in Metabolic Syndrome

(2011) Paul Jan Willem Herman Kappelle et al.   ARCHIVES OF MEDICAL RESEARCH

Dual Metabolic Defects Are Required to Produce Hypertriglyceridemia in Obese Subjects

(2011) Marja-Riitta Taskinen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CETP Inhibitor Torcetrapib Promotes Reverse Cholesterol Transport in Obese Insulin-Resistant CETP-ApoB100 Transgenic Mice

(2011) François Briand et al.   CTS-Clinical and Translational Science

Anti-inflammatory and Antioxidant Properties of HDLs Are Impaired in Type 2 Diabetes

(2011) C. Morgantini et al.   DIABETES

Nonenzymatic glycation of high-density lipoprotein impairs its anti-inflammatory effects in innate immunity

(2011) Donghui Liu et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Effect of Bariatric Surgery-Induced Weight Loss on SR-BI-, ABCG1-, and ABCA1-Mediated Cellular Cholesterol Efflux in Obese Women

(2011) Judith Aron-Wisnewsky et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

(2011) Christian Besler et al.   JOURNAL OF CLINICAL INVESTIGATION

Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters

(2011) Jose Castro-Perez et al.   JOURNAL OF LIPID RESEARCH

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Nonenzymatic Glycation Impairs the Antiinflammatory Properties of Apolipoprotein A-I

(2010) Estelle Nobécourt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of High-Density Lipoproteins on Pancreatic β-Cell Insulin Secretion

(2010) Michelle A. Fryirs et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Biliary Sterol Secretion Is Required for Functional In Vivo Reverse Cholesterol Transport in Mice

(2010) Niels Nijstad et al.   GASTROENTEROLOGY

Modifying Apolipoprotein A-I by Malondialdehyde, but Not by an Array of Other Reactive Carbonyls, Blocks Cholesterol Efflux by the ABCA1 Pathway

(2010) Baohai Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Niacin and fibrates in atherogenic dyslipidemia: Pharmacotherapy to reduce cardiovascular risk

(2010) M. John Chapman et al.   PHARMACOLOGY & THERAPEUTICS

Dysfunctional HDL as a Diagnostic and Therapeutic Target

(2009) Jonathan D. Smith   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy

(2009) Sajoscha A. Sorrentino et al.   CIRCULATION

Major Lipids, Apolipoproteins, and Risk of Vascular Disease

(2009) The Emerging Risk Factors Collaboration*   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Modification of High Density Lipoprotein by Myeloperoxidase Generates a Pro-inflammatory Particle

(2009) Arundhati Undurti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women

(2009) Bela F. Asztalos et al.   JOURNAL OF LIPID RESEARCH

Reconstituted High-Density Lipoprotein Increases Plasma High-Density Lipoprotein Anti-Inflammatory Properties and Cholesterol Efflux Capacity in Patients With Type 2 Diabetes

(2009) Sanjay Patel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

High-Density Lipoprotein Reduces the Human Monocyte Inflammatory Response

(2008) Andrew J. Murphy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reconstituted HDL infusion restores endothelial function in patients with type 2 diabetes mellitus

(2008) M. Nieuwdorp et al.   DIABETOLOGIA

Relationship of Paraoxonase 1 (PON1) Gene Polymorphisms and Functional Activity With Systemic Oxidative Stress and Cardiovascular Risk

(2008) Tamali Bhattacharyya   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hyperglycemia suppresses hepatic scavenger receptor class B type I expression

(2007) Koji Murao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic syndrome features small, apolipoprotein A-I-poor, triglyceride-rich HDL3 particles with defective anti-apoptotic activity

(2007) Juliana A. de Souza et al.   ATHEROSCLEROSIS