Discovery of Small‐Molecule Modulators of Protein–RNA Interactions by Fluorescence Intensity‐Based Binding Assay

A brave new world of RNA-binding proteins

(2018) Matthias W. Hentze et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expansion of cat-ELCCA for the Discovery of Small Molecule Inhibitors of the Pre-let-7–Lin28 RNA–Protein Interaction

(2018) Daniel A. Lorenz et al.   ACS Medicinal Chemistry Letters

Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28

(2018) Longfei Wang et al.   Cell Reports

Restoring Let-7 microRNA Biogenesis Using a Small-Molecule Inhibitor of the Protein–RNA Interaction

(2018) Donghyun Lim et al.   ACS Medicinal Chemistry Letters

RNA-binding proteins in neurodegeneration: mechanisms in aggregate

(2017) Erin G. Conlon et al.   GENES & DEVELOPMENT

Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein–RNA Complexes: An Avenue for Discovering New Drugs

(2017) Rita Nasti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of the first small-molecule CsrA–RNA interaction inhibitors using biophysical screening technologies

(2016) Christine K Maurer et al.   Future Medicinal Chemistry

Discovery of a Small-Molecule Inhibitor of Protein–MicroRNA Interaction Using Binding Assay with a Site-Specifically Labeled Lin28

(2016) Donghyun Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Precise small-molecule recognition of a toxic CUG RNA repeat expansion

(2016) Suzanne G Rzuczek et al.   Nature Chemical Biology

Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing

(2016) Helen L. Lightfoot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Illuminating biological processes through site-specific protein labeling

(2015) Gong Zhang et al.   CHEMICAL SOCIETY REVIEWS

Roquin—a multifunctional regulator of immune homeostasis

(2015) J S Schaefer et al.   GENES AND IMMUNITY

The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif

(2015) Leslie K Williams et al.   Nature Chemical Biology

Screening Technologies for Small Molecule Discovery: The State of the Art

(2014) William P. Janzen   CHEMISTRY & BIOLOGY

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

(2014) Andreas Schlundt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lin28a regulates neuronal differentiation and controls miR-9 production

(2014) Jakub S. Nowak et al.   Nature Communications

Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

(2013) Kathrin Leppek et al.   CELL

Protein induced fluorescence enhancement (PIFE) for probing protein–nucleic acid interactions

(2013) Helen Hwang et al.   CHEMICAL SOCIETY REVIEWS

Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin

(2013) Tatiana A. Dias et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins

(2013) Gražvydas Lukinavičius et al.   Nature Chemistry

Flavone-Based Novel Antidiabetic and Antidyslipidemic Agents

(2012) Alok K. Verma et al.   JOURNAL OF MEDICINAL CHEMISTRY

How does Lin28 let-7 control development and disease?

(2012) James E. Thornton et al.   TRENDS IN CELL BIOLOGY

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

Analysis of protein-ligand interactions by fluorescence polarization

(2011) Ana M Rossi et al.   Nature Protocols

Protein induced fluorescence enhancement as a single molecule assay with short distance sensitivity

(2011) H. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative approaches to monitor protein-nucleic acid interactions using fluorescent probes

(2010) J. M. Pagano et al.   RNA

Antibacterial, antifungal, and antiviral activities of some flavonoids

(2009) Didem Deliorman Orhan et al.   MICROBIOLOGICAL RESEARCH

RNA-binding proteins in human genetic disease

(2008) Kiven E. Lukong et al.   TRENDS IN GENETICS