Shikonin suppresses progression and epithelial–mesenchymal transition in hepatocellular carcinoma (HCC) cells by modulating miR‐106b/SMAD7/TGF‐β signaling pathway

Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways

(2019) Yongkang Liu et al.   Artificial Cells Nanomedicine and Biotechnology

MicroRNA-506-3p initiates mesenchymal-to-epithelial transition and suppresses autophagy in osteosarcoma cells by directly targeting SPHK1

(2019) Dapeng Wang et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Up-regulation of circ-SMAD7 inhibits tumor proliferation and migration in esophageal squamous cell carcinoma

(2019) Yanzhou Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Modulation of YrdC promotes hepatocellular carcinoma progression via MEK/ERK signaling pathway

(2019) Shiqiong Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

Association of the infiltration of tumor-associated macrophages, expression of Smad7 protein and prognosis in oral squamous cell carcinoma

(2018) Wei Wei et al.   ARCHIVES OF ORAL BIOLOGY

Long non-coding RNA KCNQ1OT1 modulates oxaliplatin resistance in hepatocellular carcinoma through miR-7-5p/ ABCC1 axis

(2018) Huiqin Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The clinical significance and biological function of lncRNA RGMB-AS1 in hepatocellular carcinoma

(2018) Nan Sheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Shikonin suppresses proliferation and induces apoptosis in endometrioid endometrial cancer cells via modulating miR-106b /PTEN/AKT/mTOR signaling pathway

(2018) Caimei Huang et al.   BIOSCIENCE REPORTS

Extract of Stellerachamaejasme L(ESC) inhibits growth and metastasis of human hepatocellular carcinoma via regulating microRNA expression

(2018) Xiaoni Liu et al.   BMC Complementary and Alternative Medicine

The Critical Role of PTEN/PI3K/AKT Signaling Pathway in Shikonin-Induced Apoptosis and Proliferation Inhibition of Chronic Myeloid Leukemia

(2018) Yu Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MiR-106b regulates the apoptosis and tumorigenesis of hepatocellular carcinoma via targeting Zinc finger and BTB domain-containing protein 7A (Zbtb7a)

(2018) Xiao Liang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

miR-181b-induced SMAD7 downregulation controls granulosa cell apoptosis through TGF-β signaling by interacting with the TGFBR1 promoter

(2018) Wang Yao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protective effect of berberine against cardiac ischemia/reperfusion injury by inhibiting apoptosis through the activation of Smad7

(2018) Weidong Yao et al.   MOLECULAR AND CELLULAR PROBES

Upregulation of MiR-212 Inhibits Migration and Tumorigenicity and Inactivates Wnt/β-Catenin Signaling in Human Hepatocellular Carcinoma

(2018) Pengbo Jia et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Bioinformatics functional analysis of let-7a, miR-34a, and miR-199a/b reveals novel insights into immune system pathways and cancer hallmarks for hepatocellular carcinoma

(2018) Bangly Soliman et al.   TUMOR BIOLOGY

Long noncoding RNA RP4 functions as a competing endogenous RNA through miR-7-5p sponge activity in colorectal cancer

(2018) Mu-Lin Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

SMAD7 in keratinocytes promotes skin carcinogenesis by activating ATM-dependent DNA repair and an EGFR-mediated cell proliferation pathway

(2018) Huyen Trang Ha Thi et al.   CARCINOGENESIS

SMAD7 is a novel independent predictor of survival in patients with cutaneous melanoma

(2018) Maciej Kaczorowski et al.   Translational Research

Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway

(2018) Bing Liu et al.   Biochemistry and Cell Biology

Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways

(2018) Zhi Lan Guo et al.   BMC CELL BIOLOGY

Dysregulated cancer cell transdifferentiation into erythrocytes is an additional metabolic stress in hepatocellular carcinoma

(2018) Abigail Hughes et al.   TUMOR BIOLOGY

Shikonin induces necroptosis by reactive oxygen species activation in nasopharyngeal carcinoma cell line CNE-2Z

(2017) Zixuan Zhang et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Shikonin Inhibited Migration and Invasion of Human Lung Cancer Cells via Suppression of c-Met-Mediated Epithelial-to-Mesenchymal Transition

(2017) Yei-San Hsieh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Metabolic profiling study of shikonin's cytotoxic activity in the Huh7 human hepatoma cell line

(2017) E. D. Spyrelli et al.   Molecular BioSystems

Downregulation of miR-106b attenuates inflammatory responses and joint damage in collagen-induced arthritis

(2017) Yunxia Tao et al.   RHEUMATOLOGY

MiR-183 overexpression inhibits tumorigenesis and enhances DDP-induced cytotoxicity by targeting MTA1 in nasopharyngeal carcinoma

(2017) Guanghui Wang et al.   TUMOR BIOLOGY

Study on the value of serum miR-106b for the early diagnosis of hepatocellular carcinoma

(2017) Bao-Min Shi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

HBeAg-induced miR-106b promotes cell growth by targeting the retinoblastoma gene

(2017) Jasmine Samal et al.   Scientific Reports

The protective effects of shikonin on hepatic ischemia/reperfusion injury are mediated by the activation of the PI3K/Akt pathway

(2017) Tong Liu et al.   Scientific Reports

Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300

(2016) Yun-Ji Jeung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MiR-106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh’s esophageal squamous cell carcinoma

(2016) Fang Dai et al.   TUMOR BIOLOGY

miR-106b promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma

(2016) Chia-Sheng Yen   WORLD JOURNAL OF GASTROENTEROLOGY

Comparability of Mixed IC50 Data – A Statistical Analysis

(2013) Tuomo Kalliokoski et al.   PLoS One

Targeting Stat3 and Smad7 to restore TGF-β cytostatic regulation of tumor cells in vitro and in vivo

(2012) R B Luwor et al.   ONCOGENE

Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells

(2010) Nie Yingkun et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY