Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways

miR-202 functions as a tumor suppressor in non-small cell lung cancer by targeting STAT3

(2017) Zhonghai Zhao et al.   Molecular Medicine Reports

Inhibition of MMP-2 Expression Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinoma by Suppressing the PI3K/AKT/mTOR Pathway

(2017) Wenliang Tan et al.   ONCOLOGY RESEARCH

Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway

(2017) Xia Li et al.   PHARMACOLOGICAL RESEARCH

Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo

(2016) Guodong He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Shikonin Inhibits the Proliferation of Human Breast Cancer Cells by Reducing Tumor-Derived Exosomes

(2016) Yao Wei et al.   MOLECULES

Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species

(2016) Wenquan Liang et al.   Scientific Reports

HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells

(2015) Dae-Hee Lee et al.   CELLULAR SIGNALLING

Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy

(2015) Xiaoyun Dai et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation

(2015) Wenjuan Li et al.   PLoS One

Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells

(2014) Dongzhu Duan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sensitizing the Therapeutic Efficacy of Taxol with Shikonin in Human Breast Cancer Cells

(2014) Wenjuan Li et al.   PLoS One

Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

(2014) R Trivedi et al.   Cell Death & Disease

Inhibition of the Signal Transducers and Activators of Transcription (STAT) 3 Signalling Pathway by AG490 in Laryngeal Carcinoma Cells

(2013) H Zhang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting Death Receptor TRAIL-R2 by Chalcones for TRAIL-Induced Apoptosis in Cancer Cells

(2012) Ewelina Szliszka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma

(2011) Ke Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Targeting c-FLIP in cancer

(2010) Sarah Shirley et al.   CANCER LETTERS

The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells

(2010) N Goncharenko-Khaider et al.   ONCOGENE

Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer

(2009) Stuart A Rushworth et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells

(2008) Xin Mao et al.   CELL RESEARCH

TRAIL receptor-targeted therapeutics: Resistance mechanisms and strategies to avoid them

(2008) A THORBURN et al.   DRUG RESISTANCE UPDATES

The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

(2008) S Wang   ONCOGENE

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by shikonin was partly through the inactivation of NF-κB pathway

(2007) Min Ruan et al.   PHYTOTHERAPY RESEARCH