Chrysophanol exhibits inhibitory activities against colorectal cancer by targeting decorin

Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer

(2018) Kaili Liu et al.   CANCER SCIENCE

Chrysophanol inhibits endoplasmic reticulum stress in cerebral ischemia and reperfusion mice

(2018) Yongmei Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular mechanisms of anti-inflammatory effect of chrysophanol, an active component of AST2017-01 on atopic dermatitis in vitro models

(2018) Hyun-Ja Jeong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antibacterial screening of Rumex species native to the Carpathian Basin and bioactivity-guided isolation of compounds from Rumex aquaticus

(2017) Orsolya Orbán-Gyapai et al.   FITOTERAPIA

Gold-chrysophanol nanoparticles suppress human prostate cancer progression through inactivating AKT expression and inducing apoptosis and ROS generation in vitro and in vivo

(2017) Li Lu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Colorectal Cancer Incidence Patterns in the United States, 1974–2013

(2017) Rebecca L. Siegel et al.   JNCI-Journal of the National Cancer Institute

Colorectal Cancer Incidence Patterns in the United States, 1974–2013

(2017) Rebecca L. Siegel et al.   JNCI-Journal of the National Cancer Institute

The extracellular matrix regulates the effect of decorin and transforming growth factor beta-2 (TGF-β2) on myoblast migration

(2016) K.P. Goetsch et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Second St. Gallen European Organisation for Research and Treatment of Cancer Gastrointestinal Cancer Conference: consensus recommendations on controversial issues in the primary treatment of rectal cancer

(2016) Manfred P. Lutz et al.   EUROPEAN JOURNAL OF CANCER

Chrysophanol Induces Apoptosis of Choriocarcinoma Through Regulation of ROS and the AKT and ERK1/2 Pathways

(2016) Whasun Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice

(2016) Kai Zhang et al.   NEUROSCIENCE LETTERS

Systemic Delivery of an Oncolytic Adenovirus Expressing Decorin for the Treatment of Breast Cancer Bone Metastases

(2015) Yuefeng Yang et al.   HUMAN GENE THERAPY

Potent antitumor effect of neurotensin receptor-targeted oncolytic adenovirus co-expressing decorin and Wnt antagonist in an orthotopic pancreatic tumor model

(2015) Youjin Na et al.   JOURNAL OF CONTROLLED RELEASE

Decorin in Human Colon Cancer

(2015) Marie C. Nyman et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Laparoscopic Versus Open Surgery for Rectal Cancer: A Systematic Review and Meta-analysis of Randomized Controlled Trials

(2015) Feng-Wa Zhang et al.   Asian Pacific Journal of Cancer Prevention

Decorin Suppresses Prostate Tumor Growth through Inhibition of Epidermal Growth Factor and Androgen Receptor Pathways

(2015) Yunping Hu et al.   NEOPLASIA

The systemic delivery of an oncolytic adenovirus expressing decorin inhibits bone metastasis in a mouse model of human prostate cancer

(2014) W Xu et al.   GENE THERAPY

Decreased decorin expression in the tumor microenvironment

(2014) Benedek Bozoky et al.   Cancer Medicine

Lentiviral-Encoded shRNA Silencing of Proteoglycan Decorin Enhances Tendon Repair and Regeneration within a Rat Model

(2013) Ping Lu et al.   CELL TRANSPLANTATION

Proteomic analysis of perfluorooctane sulfonate-induced apoptosis in human hepatic cells using the iTRAQ technique

(2013) Qingyu Huang et al.   JOURNAL OF APPLIED TOXICOLOGY

Decorin deficiency promotes hepatic carcinogenesis

(2013) Zsolt Horváth et al.   MATRIX BIOLOGY

iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells

(2013) Hao Chen et al.   PROTEOMICS

Decorin-mediated inhibition of cholangiocarcinoma cell growth and migration and promotion of apoptosis are associated with E-cadherin in vitro

(2013) Xiang Yu et al.   TUMOR BIOLOGY

Chrysophanol-induced necrotic-like cell death through an impaired mitochondrial ATP synthesis in Hep3B human liver cancer cells

(2012) Chien-Hang Ni et al.   ARCHIVES OF PHARMACAL RESEARCH

Chrysophanol-induced cell death (necrosis) in human lung cancer A549 cells is mediated through increasing reactive oxygen species and decreasing the level of mitochondrial membrane potential

(2012) Chien-Hang Ni et al.   ENVIRONMENTAL TOXICOLOGY

Decorin–TGFβ Axis in Hepatic Fibrosis and Cirrhosis

(2012) Kornélia Baghy et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Decorin Protein Core Affects the Global Gene Expression Profile of the Tumor Microenvironment in a Triple-Negative Orthotopic Breast Carcinoma Xenograft Model

(2012) Simone Buraschi et al.   PLoS One

Knockdown of aberrantly expressed nuclear localized decorin attenuates tumour angiogenesis related mediators in oral cancer progression model in vitro

(2012) Nyla Dil et al.   Head and Neck Optical Diagnostics Society

A role for decorin in a murine model of allergen-induced asthma

(2011) Cinzia L. Marchica et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice

(2011) X. Bi et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Proteomic analysis andin vitrodevelopmental toxicity tests for mechanism-based safety evaluation of chemicals

(2011) Makoto Usami et al.   Expert Review of Proteomics

Colorectal cancer

(2010) David Cunningham et al.   LANCET

Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway

(2010) Myung Sun Lee et al.   PHYTOTHERAPY RESEARCH

Presence of activating KRAS mutations correlates significantly with expression of tumour suppressor genes DCN and TPM1 in colorectal cancer

(2009) Vid Mlakar et al.   BMC CANCER

Late Side Effects and Quality of Life After Radiotherapy for Rectal Cancer

(2009) Kjersti Bruheim et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation

(2008) X. Bi et al.   CARCINOGENESIS