Article
Oncology
Xiang Xu, Na Li, Yugang Wang, Jinming Yu, Jun Mi
Summary: The upregulation of calcium channel TRPV6 is associated with poor prognosis in breast cancer by promoting invasion and metastasis, making it a potential target for therapy. TRPV6 expression is increased in metastatic breast cancers, accelerating primary breast cancer cell migration. Mechanistically, TRPV6 activates NFATC2 through NFATC2IP phosphorylation, leading to increased breast cancer metastasis via upregulation of ADAMTS6 expression.
Article
Oncology
Ming Zhang, Jue Wang, Yucui Jin, Que Zheng, Mengying Xing, Yuting Tang, Yunfei Ma, Lingyun Li, Bing Yao, Hao Wu, Changyan Ma
Summary: The study reveals the important role of FGF14-AS2 in the bone metastasis of breast cancer. It inhibits osteoclast differentiation by suppressing the translation of RUNX2 through the inhibition of eIF4E/eIF4G complex assembly and eIF4E phosphorylation, resulting in reduced transcription of RANKL. FGF14-AS2 expression is downregulated by YTHDF2-mediated RNA degradation in an m(6)A-dependent manner. Clinical analysis shows that patients with high YTHDF2 and low FGF14-AS2 expression levels have worse distant metastasis-free survival.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Yingru Xu, Shuxia Zhang, Xinyi Liao, Man Li, Suwen Chen, Xincheng Li, Xingui Wu, Meisongzhu Yang, Miaoling Tang, Yameng Hu, Ziwen Li, Ruyuan Yu, Mudan Huang, Libing Song, Jun Li
Summary: A novel circRNA, circIKBKB, was significantly upregulated in bone-metastatic breast cancer tissues. CircIKBKB enhanced the ability of breast cancer cells to induce bone pre-metastatic niche formation by promoting osteoclastogenesis and activating the NF-kappa B pathway. Inhibiting circIKBKB expression effectively suppressed breast cancer bone metastasis, indicating a potential therapeutic strategy.
Article
Biochemistry & Molecular Biology
Lili Gao, Junzhe Zhang, Qianqian Long, Yang Yang, Yiming Li, Guoqiang Li, Peng Pu, Shanshi Tong, Yamin He, Qing Li, Yang Chen, Yingbin Liu, Xianming Kong
Summary: This study reveals a novel pathway, the SETD7/YY1 axis, which regulates epithelial-mesenchymal transition and tumor cell migration via the ERK/MAPK pathway in triple-negative breast cancer (TNBC). These findings suggest a potential therapeutic target for advanced TNBC treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Shuya Luo, Hui Wang, Lichuan Bai, Yiwen Chen, Si Chen, Kuan Gao, Huijie Wang, Shuwei Wu, Hanbin Song, Ke Ma, Mei Liu, Fan Yao, Yue Fang, Qinghuan Xiao
Summary: Activation of TMEM16A promoted breast cancer cell migration and invasion in vitro as well as breast cancer metastasis in mice. Patients with higher TMEM16A levels showed greater lymph node metastasis and shorter survival.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Cell Biology
Rong Deng, Hai-Liang Zhang, Jun-Hao Huang, Rui-Zhao Cai, Yan Wang, Yu-Hong Chen, Bing-Xin Hu, Zhi-Peng Ye, Zhi-Ling Li, Jia Mai, Yun Huang, Xuan Li, Xiao-Dan Peng, Gong-Kan Feng, Jun-Dong Li, Jun Tang, Xiao-Feng Zhu
Summary: ULK1 deficiency impairs mitophagy in breast cancer cells under hypoxia, leading to accumulation of damaged mitochondria, NLRP3 inflammasome activation, and bone metastasis. Phosphorylation of ULK1 triggers its degradation, and a negative correlation between ULK1 expression levels and p-MAPK1/3 was observed. The use of MAP2K/MEK inhibitor trametinib can restore mitophagy function and inhibit NLRP3 inflammasome activation to reduce bone metastasis.
Article
Oncology
Toru Hiraga, Kanji Horibe, Masanori Koide, Teruhito Yamashita, Yasuhiro Kobayashi
Summary: The secreted protein sclerostin, primarily produced by osteocytes, inhibits osteoblast differentiation and function by suppressing the canonical Wnt signaling pathway. Inhibition of sclerostin has been shown to increase bone formation and treatment with an anti-sclerostin antibody has been approved for osteoporosis. In this study, it was found that blocking sclerostin activates canonical Wnt signaling in breast cancer cells metastasized to bone, leading to increased bone metastases through enhancing stem cell-like properties of cancer cells and osteoclastogenesis.
Article
Cell Biology
Weixiao Huang, Xiong Liu, Yao Zhang, Mingxia Deng, Guangqiang Li, Guo Chen, Li Yu, Lai Jin, Tongzheng Liu, Yijie Wang, Yan Chen
Summary: USP5 is a novel deubiquitinase for HIF2 alpha in breast cancer, interacting with HIF2 alpha to protect it from degradation. USP5 promotes the transcription of HIF2 alpha target genes and its high expression is correlated with poor clinical outcomes in breast cancer patients.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Ri Chen, Chunfan Zhang, Yuanda Cheng, Shaoqiang Wang, Hang Lin, Heng Zhang
Summary: The long non-coding RNA UCC acts as a competing endogenous RNA of miR-143-3p and upregulates SOX5 by absorbing miR-143-3p, resulting in proliferation and migration of non-small-cell lung cancer (NSCLC) cells both in vitro and in vivo. UCC enhances carcinogenesis of NSCLC cells via the miR-143-3p/SOX5 axis, which may function as a novel target for NSCLC treatment.
LABORATORY INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Ying Zhang, Tian-Tian Zhang, Lin Gao, Ya-Nan Tan, Yu-Ting Li, Xiang-Yu Tan, Tu-Xiong Huang, Hua-Hui Li, Feng Bai, Chang Zou, Xin-Hai Pei, Bin-Bin Tan, Li Fu
Summary: MTAP is frequently downregulated in breast cancer and its low expression is associated with poor survival of patients. It functions as a suppressor of tumor growth and metastasis by regulating ODC activity. These findings suggest that MTAP could be a promising therapeutic target for breast cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Cell Biology
Mengyao Xu, Shan Huang, Xiaoli Dong, Yanan Chen, Miao Li, Wen Shi, Guanwen Wang, Chongbiao Huang, Qiong Wang, Yanhua Liu, Peiqing Sun, Shuang Yang, Rong Xiang, Antao Chang
Summary: ATOH8-V1 is a novel pro-metastatic factor in breast cancer, enhancing cancer metastasis by directly binding to the RhoC promoter and stimulating its expression. It could be a potential therapeutic target for the treatment of metastatic cancers.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Pathology
Rui Zhang, Ziqi Meng, Xuwei Wu, Meihua Zhang, Songnan Zhang, Tiefeng Jin
Summary: The research demonstrated that Mortalin promotes proliferation, metastasis, and malignant progression of breast cancer, potentially through the Wnt/beta-Catenin signaling pathway. This suggests that Mortalin could serve as a biomarker and prognostic factor in breast cancer.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Oncology
Alexandra Q. Bartlett, Nathan D. Pennock, Alex Klug, Pepper Schedin
Summary: This study discusses the mechanisms of breast cancer cells invading the liver and forming metastatic niches. The research found that the process of liver involution increases liver metastasis, which is associated with unique immunological properties in the involuting liver.
Article
Medicine, Research & Experimental
Qian Li, Xuejiao Lv, Chunyong Han, Yu Kong, Zhongye Dai, Dawei Huo, Ting Li, Dapeng Li, Wei Li, Xing Wang, Qian Zhao, Jie Ming, Wen Yang, Yang Chen, Xudong Wu
Summary: This study investigates the transcriptomic and epigenomic features of NFs and CAFs associated with breast cancer metastasis, and identifies signature genes and enhancers specific to CAFs. The study demonstrates the importance of activated JUN in remodeling enhancers and maintaining the activation of CAF-specific enhancers, leading to breast cancer invasiveness. These findings provide insights into stroma cell transformation and support the potential of stroma-targeting strategy in cancer treatment.
Article
Oncology
Shitao Zou, Yan Xu, Xingxing Chen, Chao He, Aidi Gao, Jundong Zhou, Yihong Chen
Article
Virology
Connie Zhao, Amy M. Princiotto, Hanh T. Nguyen, Shitao Zou, Meiqing Lily Zhao, Shijian Zhang, Alon Herschhorn, Mark Farrell, Karanbir Pahil, Bruno Melillo, Somisetti Sambasivarao, Cameron Abrams, Amos B. Smith, Navid Madani, Joseph Sodroski
JOURNAL OF VIROLOGY
(2019)
Article
Virology
Shitao Zou, Shijian Zhang, Althea Gaffney, Haitao Ding, Maolin Lu, Jonathan R. Grover, Mark Farrell, Hanh T. Nguyen, Connie Zhao, Saumya Anang, Meiqing Zhao, Mohammadjavad Mohammadi, Scott C. Blanchard, Cameron Abrams, Navid Madani, Walther Mothes, John C. Kappes, Amos B. I. I. I. I. I. I. Smith, Joseph Sodroski
JOURNAL OF VIROLOGY
(2020)
Article
Medicine, Research & Experimental
Chao Gu, Shitao Zou, Chao He, Jundong Zhou, Rui Qu, Qin Wang, Jie Qi, Ming Zhou, Shuai Yan, Zhenyu Ye
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2020)
Article
Oncology
Yuandong Cao, Aidi Gao, Xiaoqing Li, Han Min, Chao He, Xinchen Sun, Wei-Qun Ding, Jundong Zhou
Summary: TAB182 is identified as a key regulator of radiation sensitivity in ESCC cells, with its downregulation sensitizing cancer cells to ionizing radiation and overcoming radioresistance by interacting with FHL2 to modulate the G2-M checkpoint.
Article
Oncology
Zhenzi Su, Aidi Gao, Xiaoqing Li, Shitao Zou, Chao He, Jinchang Wu, Wei-Qun Ding, Jundong Zhou
Summary: Pol iota activates G6PD through Erk-OGT-induced O-GlcNAcylation to promote the proliferation and progression of ESCC, supporting the notion that Pol iota is a potential biomarker and therapeutic target of ESCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Virology
Hanh T. Nguyen, Alessandra Qualizza, Saumya Anang, Meiqing Zhao, Shitao Zou, Rong Zhou, Qian Wang, Shijian Zhang, Ashlesha Deshpande, Haitao Ding, Ta-Jung Chiu, Amos B. Smith, John C. Kappes, Joseph G. Sodroski
Summary: Developing an efficient vaccine is crucial for combating global HIV-1 infection. The instability of the pretriggered shape of the viral envelope glycoprotein makes it challenging to raise neutralizing antibodies against HIV-1. By introducing multiple changes in Env, researchers derived two HIV-1 Env variants enriched in state 1, which can be efficiently cross-linked to maintain the desired shape. These findings suggest a potential path towards better vaccine development by characterizing the native pretriggered Env structure.
JOURNAL OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Shuwen Zhang, Shitao Zou, Deyao Yin, Lihong Zhao, Daniel Finley, Zhaolong Wu, Youdong Mao
Summary: This study presents high-resolution cryo-electron microscopy structures of human USP14 in complex with the 26S proteasome, revealing two pathways of proteasome state transitions induced by USP14. The findings also highlight the dynamic USP14-ATPase interactions that decouple ATPase activity from deubiquitylation and introduce regulatory checkpoints in the proteasome function. These results provide insights into the complete functional cycle of the USP14-regulated proteasome and have implications for the development of USP14-targeted therapies.
Article
Oncology
Xiaoqing Li, Shitao Zou, Liangsu Zhou, Aidi Gao, Jing Xu, Chao He, Jundong Zhou, Shuhua Wu, Yihong Chen
Summary: This study found that high RAD18 expression is associated with a poorer prognosis in ESCC patients who received radiotherapy. Lowering RAD18 expression increased the sensitivity of ESCC cells to radiation and prolonged DNA damage repair time. RAD18 regulates radioresistance through non-homologous end joining pathway.
Article
Oncology
Yan Xu, Xiaojun Zhou, Ling Gao, Su Yan, Zhenyun Li, Daiyi Zhang, Jianhong Pu, Shitao Zou, Zhongqi Mao
Summary: This study aimed to identify and demonstrate novel oncogenes for colorectal cancer (CRC) using bioinformatics analysis. The researchers analyzed CRC data from various databases and identified several potential diagnostic and prognostic biomarkers, including HAGHL. They found that HAGHL is positively related to d-lactate levels and negatively associated with patient prognosis in CRC. Furthermore, they showed that downregulation of HAGHL suppresses d-lactate production and induces apoptosis, leading to inhibition of CRC cell proliferation. This study highlights the importance of HAGHL as a potential therapeutic target for CRC treatment.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Virology
Shijian Zhang, Hanh T. Nguyen, Haitao Ding, Jia Wang, Shitao Zou, Lihong Liu, Debjani Guha, Dana Gabuzda, David D. Ho, John C. Kappes, Joseph Sodroski
Summary: HIV-1 utilizes two pathways to transport its envelope glycoprotein (Env) to the surface of infected cells, resulting in different populations of Env with varying degrees of cleavage and glycosylation. While cleaved, functional Env is efficiently incorporated into virus particles, an uncleaved form of Env is mostly excluded from virions, potentially acting as a decoy to the host immune system without compromising virus infectivity.
JOURNAL OF VIROLOGY
(2021)
Article
Oncology
Zhonghua Ning, Xiaozhong Zhu, Youqin Jiang, Aidi Gao, Shitao Zou, Chao Gu, Chao He, Yihong Chen, Wei-Qun Ding, Jundong Zhou