Article
Chemistry, Applied
Junghan Lee, Enkhzaya Davaa, Yixin Jiang, Kyung-Ju Shin, Min Hye Kim, Hyunsu An, Jinho Kim, Su-Geun Yang, Steve K. Cho
Summary: In this study, we designed a photo-triggered reactive oxygen species (ROS)-generating nanoparticle and demonstrated its combined therapeutic effects against ovarian cancer. The study also identified a correlation between cancer stem cell markers and poor clinical outcomes in ovarian cancer patients, and showed that the nanoparticle could actively target these cancer stem cells. The experimental results indicated therapeutic effects of the nanoparticle both in vitro and in vivo, potentially overcoming the local therapeutic limitation of photodynamic therapy.
CARBOHYDRATE POLYMERS
(2022)
Article
Health Care Sciences & Services
Vladimir Subr, Robert Pola, Shanghui Gao, Rayhanul Islam, Takuma Hirata, Daiki Miyake, Kousuke Koshino, Jian-Rong Zhou, Kazumi Yokomizo, Jun Fang, Tomas Etrych
Summary: Biodegradable nanomedicines tailored for tumor-associated stimuli-sensitive drug release and polymer system degradation have advanced potential for anticancer polymer therapeutics. The diblock polymer systems designed in this study showed comparable in vitro cytotoxicity, intracellular uptake, and intratumor penetration properties to linear polymer conjugates. Moreover, the diblock nanomedicines showed remarkable in vivo anti-tumor efficacy, far superior to conventional linear polymer conjugates.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Leticia Oliveira-Ferrer, Barbara Schmalfeldt, Johannes Dietl, Catharina Bartmann, Udo Schumacher, Christine Stuerken
Summary: This study analyzed hyaluronan (HA) deposition in ovarian cancer tissues and found that pericellular tumor-cell-associated HA deposition was significantly associated with malignancy and represented an independent unfavorable prognostic marker for overall survival. Additionally, high mRNA levels of CD44, HAS2, and HAS3 were significantly associated with pericellular HA deposition in cancer cells. In contrast, stromal hyaluronan deposition had no impact on ovarian cancer prognosis.
Review
Biochemistry & Molecular Biology
Eleni Sflakidou, George Leonidis, Eirini Foroglou, Christos Siokatas, Vasiliki Sarli
Summary: Cancer is a leading cause of death worldwide. Natural products have been used for cancer treatment since ancient times, but their limitations in pharmacokinetics, selectivity, and efficacy against drug-resistant cancer cells hinder their clinical application. Conjugation of natural products with other bioactive molecules can overcome these limitations and develop novel bifunctional drugs for cancer therapy.
Article
Biochemistry & Molecular Biology
Huixia Hu, Huimin Yong, Xiyu Yao, Dawei Yun, Jinbao Huang, Jun Liu
Summary: The study successfully functionalized cassava starch aldehyde with catechin through acid catalyzed condensation reaction, forming conjugates with high stability and strong antioxidant activity. The conjugates showed higher stability than free catechin, enhanced reducing power and radical scavenging activity, and could potentially be used as antioxidants in the food industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Eirini-Maria Giatagana, Andrey Kuskov, Aristidis M. Tsatsakis, George N. Tzanakakis, Dragana Nikitovic
Summary: The tumor microenvironment (TME) is composed of various cells and extracellular matrix components. Changes in the structure and sulfation pattern of GAGs are associated with cancer progression. GAGs and GAG-based molecules show promise as potential effectors for anticancer therapy due to their unique properties.
Review
Biochemistry & Molecular Biology
Victoria O. Hunsu, Caroline O. B. Facey, Jeremy Z. Fields, Bruce M. Boman
Summary: Retinoic acid (RA) agents show anti-tumor activity by inducing cellular differentiation, but have not yet been widely used for systemic treatment in most solid tumors. RA signaling is mediated through retinoic receptor subtypes, with mutations in these receptors offering opportunities for target discovery in personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jessica Pougoue Ketchemen, Hanan Babeker, Anjong Florence Tikum, Anand Krishnan Nambisan, Fabrice Ngoh Njotu, Emmanuel Nwangele, Humphrey Fonge
Summary: Two domain-specific ADCs were developed and characterized in this study. The combination of these ADCs showed additive benefits, with lower IC50 and higher pharmacokinetics, indicating improved therapeutic effects against HER2.
BRITISH JOURNAL OF CANCER
(2023)
Article
Behavioral Sciences
Paul Anthony Martinez, Vanessa Elia Martinez, Sheela Rani, Meredith Murrell, Martin Javors, Jonathan Gelfond, Jonathan Alan Doorn, Elizabeth Fernandez, Randy Strong
Summary: The presence of biogenic aldehydes in the brain of postmortem Parkinson's disease patients and their ability to modify proteins and cause cross-linking has raised the possibility of their involvement in the disease. In this study, mice lacking the two aldehyde dehydrogenase enzymes responsible for detoxifying one of these aldehydes were crossed with mice that overexpress human alpha-synuclein, a protein associated with Parkinson's disease. The results showed that the combination of the aldehyde deficiency and alpha-synuclein overexpression resulted in more severe motor deficits than either factor alone.
BRAIN AND BEHAVIOR
(2023)
Review
Medicine, General & Internal
Michele Zanoni, Sara Bravaccini, Francesco Fabbri, Chiara Arienti
Summary: Aldehyde dehydrogenases (ALDHs) are detoxifying enzymes often upregulated in cancer cells and associated with therapeutic resistance. ALDHs have various functions in cancer stem cells and immune cells, playing a crucial role in cancer treatment.
FRONTIERS IN MEDICINE
(2022)
Review
Endocrinology & Metabolism
David Standing, Prasad Dandawate, Shrikant Anant
Summary: Prolactin (PRL) is a peptide hormone secreted by the anterior pituitary gland, and its receptor PRLR plays a role in various cancers. PRL binding to PRLR leads to downstream signaling that promotes cancer progression. The PRLR signaling pathway is an attractive target for drug development in cancer treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Adilet Beishenaliev, Yean Leng Loke, Sook Jing Goh, Hui Nee Geo, Malar Mugila, Misni Misran, Lip Yong Chung, Lik Voon Kiew, Steve Roffler, Yin Yin Teo
Summary: Monospecific antibodies have limitations in delivering drugs to tumors with multiple epitopes, while bispecific antibodies provide a promising alternative by simultaneously targeting two distinct antigens or epitopes. This review discusses the roles of bispecific antibodies in enhancing the internalization and intracellular trafficking of drug-conjugated antibodies and facilitating the delivery of drug-encapsulating nanoconstructs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Multidisciplinary
Guo ZhiCheng, Yao MengMeng, Sun Hong, Shi MingYue, Dong XiaoRu, He ShaoShuai, Guo BingYan, Yao FangLian, Zhang Hong, Li Junhe
Summary: This study developed a new type of lithium-ion battery storage device, which improved the energy density and cycling stability of the battery by using porous nano-silicon-based negative electrode materials and high-performance phosphate salt-bridge electrolyte.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Lei Xing, Chen-Xi Yang, Di Zhao, Li-Jun Shen, Tian-Jiao Zhou, Yu-Yang Bi, Zhang-Jian Huang, Qiong Wei, Ling Li, Fei Li, Hu-Lin Jiang
Summary: Tolfplatin is a carrier-free self-delivered nanopmdrug that can inhibit tumor proliferation and metastasis by reducing PGE2 secretion and inducing apoptotic cell death.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Keita Ito, Hiroto Furukawa, Hiroshi Inaba, Shino Ohshima, Yoshie Kametani, Masatoshi Maeki, Manabu Tokeshi, Xuhao Huang, Kazuya Kabayama, Yoshiyuki Manabe, Koichi Fukase, Kazunori Matsuura
Summary: We present a potential cancer vaccine candidate using an antigen/adjuvant-displaying enveloped viral replica as a novel vaccine platform. The capsid, made of self-assembled β-annulus peptide conjugated with an HER2-derived antigenic CH401 peptide, was enclosed within a lipid bilayer containing the lipidic adjuvant α-GalCer. Precise control of the capsid size to approximately 100 nm was achieved using an artificial viral capsid as a scaffold, which is optimal for delivery to lymph nodes. The encapsulation of the capsid by the lipid bilayer improved its stability and enhanced its uptake by dendritic cells through conversion of its surface charge to cationic. The developed CH401/α-GalCer-displaying enveloped viral replica showed remarkable antibody-production activity. This study represents a pioneering example of precise vaccine design through bottom-up construction and opens new avenues for effective vaccine development.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Correction
Multidisciplinary Sciences
Kristina Nesporova, Vojtech Pavlik, Barbora Safrankova, Hana Vagnerova, Pavel Odraska, Ondrej Zidek, Natalie Cisarova, Svitlana Skoroplyas, Lukas Kubala, Vladimir Velebny
Summary: The paper has been amended with a link provided at the top for access.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Vojtech Pavlik, Lubos Sobotka, Jaroslav Pejchal, Martin Cepa, Kristina Nesporova, Monika Arenbergerova, Adela Mrozkova, Vladimir Velebny
Summary: The study compared the healing of chronic wounds treated with a standard silver dressing and a dressing containing octenidine antiseptic, finding that the octenidine dressing promoted wound healing, reduced wound slough, and observed direct effects of silver on wound cells during treatment.
Article
Chemistry, Applied
Matej Simek, Kristina Nesporova, Anna Kocurkova, Tereza Foglova, Gabriela Ambrozova, Vladimir Velebny, Lukas Kubala, Martina Hermannova
Summary: The in vivo fate of hyaluronan is influenced by its molecular weight, with low Mw hyaluronan being more efficiently eliminated while high Mw hyaluronan exhibits saturable kinetics. Hyaluronan is taken up by liver cells and metabolized into activated sugars in a similar manner regardless of its molecular weight. The use of 13C-labeling combined with LC-MS is an effective approach to studying the biological activities of hyaluronan.
CARBOHYDRATE POLYMERS
(2021)
Review
Dermatology
Romana Sinova, Vojtech Pavlik, Martin Ondrej, Vladimir Velebny, Kristina Nesporova
Summary: The study provides an overview of the literature concerning changes in hyaluronan in photoaged skin, as well as its potential role in photoaging. It suggests novel contributions of hyaluronan based on its role in other pathological processes, and discusses potential interventions targeting hyaluronan metabolism to mitigate photoaging.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiri Mrazek, Jaroslav Kohout, Tomas Kmjec, Kristina Nesporova, Josef Chmelar, Lukas Kubala, Vladimir Velebny
Summary: Water-insoluble hyaluronan films crosslinked by trivalent iron were developed as potential resorbable implants by sorption of ferric salt into solid HA films. The heterogeneously crosslinked films remained tough and stable when rehydrated, leading to better biocompatibility compared to homogeneous ferric hyaluronate gels. Mossbauer spectroscopy revealed diiron complexes in the films, while the iron in homogeneous films existed as nanoparticles or amorphous structures.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Petra Zadnikova, Romana Sinova, Vojtech Pavlik, Matej Simek, Barbora Safrankova, Martina Hermannova, Kristina Nesporova, Vladimir Velebny
Summary: This study characterizes the distribution and activity of hyaluronidases and other proteins involved in the degradation of hyaluronan (HA) in healthy human skin. It also identifies a novel hyaluronidase TMEM2 and a protein CEMIP involved in HA degradation, which were localized in the human epidermis and dermis.
Article
Biochemistry & Molecular Biology
Vojtech Pavlik, Veronika Machalova, Martin Cepa, Romana Sinova, Barbora Safrankova, Jaromir Kulhanek, Tomas Drmota, Lukas Kubala, Gloria Huerta-Angeles, Vladimir Velebny, Kristina Nesporova
Summary: The study found that HA-atRA upregulated gene expression similarly to atRA, but HA-atRA activated the expression of cholesterol metabolism genes. The results showed that HA-atRA removed cholesterol from the cells and induced cholesterol synthesis to replenish it. Additionally, HA-C18:1 also removed cholesterol from the cells, indicating that the cholesterol removal stemmed from the amphiphilic nature of these derivatives.
Review
Biochemistry & Molecular Biology
Anna Kocurkova, Kristina Nesporova, Miriam Sandanusova, Michaela Kerberova, Katerina Lehka, Vladimir Velebny, Lukas Kubala, Gabriela Ambrozova
Summary: Formation of peritoneal adhesions is a major complication following intra-abdominal surgery, primarily caused by activation of cells and deposition of extracellular matrix. Hyaluronan plays an important role in this process.
Article
Biochemistry & Molecular Biology
Nela Pilbauerova, Jan Schmidt, Tomas Soukup, Tomas Prat, Kristina Nesporova, Vladimir Velebny, Jakub Suchanek
Summary: This study investigated the use of high-molecular-hyaluronic acid (HMW-HA) as a cryoprotectant for human mesenchymal stem cells (hMSCs) to reduce DMSO concentration in the cryopreservation medium. The results showed that HMW-HA combined with lower DMSO concentrations improved total cell count, viability, and proliferation potential of hMSCs post-cryopreservation, without affecting their differentiation ability.
Article
Chemistry, Applied
Barbora Brtkova, Martina Hermannova, Josef Chmelar, Kristina Nesporova, Anna Kocurkova, Lukas Kubala, Gabriela Ambrozova, Vladimir Velebny, Matej Simek
Summary: Hyaluronan is extensively researched as a biocompatible and biodegradable material for biomedical applications. The fate and safety of hyaluronan derivatives were investigated in-vivo using stable isotope-labelling and LC-MS analysis. The derivatives were slowly degraded, absorbed, and metabolized, with no observable accumulation in the body. The acylation of hyaluronan extended its presence in the peritoneal cavity, and its degradation products were non-toxic.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Anna Kocurkova, Michaela Kerberova, Kristina Nesporova, Katerina Lehka, Miriam Sandanusova, Matej Simek, Vladimir Velebny, Lukas Kubala, Gabriela Ambrozova
Summary: Peritoneal adhesions are fibrotic complications due to peritoneal inflammation. The study suggests that endogenous hyaluronic acid (HA) plays an important role in regulating fibrosis-related pathologies. Changes in HA metabolism were observed in the early stages of peritoneal adhesion development. In vitro studies using human and mouse mesothelial cells showed that HA production can be attenuated by modulators of carbohydrate metabolism, leading to decreased expression of fibrotic markers and fibrotic cluster formation.
Article
Chemistry, Applied
Katerina Lehka, Jana Starigazdova, Jiri Mrazek, Kristina Nesporova, Matej Simek, Vojtech Pavlik, Josef Chmelar, Martin Cepa, Martin Eugenio Barrios-Llerena, Anna Kocurkova, Eva Krivakova, Ludmila Koukalova, Lukas Kubala, Vladimir Velebny
Summary: The foreign body response (FBR) is a series of reactions that occur after the implantation of biomaterials, leading to the formation of a fibrotic capsule and health complications. The severity of the FBR is influenced by the physicochemical characteristics of the implant, implantation method, and immune system activation. In this study, we present an in vitro model that evaluates protein sorption and cell adhesion on implanted materials to assess their potential to induce FBR in the peritoneum. Our model demonstrated that fibrinogen plays a crucial role in driving cell adhesion, while surface hydrophobicity/hydrophilicity and quantity of adsorbed proteins were not determining factors. The dissolution rate of the material was found to be a crucial factor in inducing long-term cell adhesion and FBR. This model helps predict the probability of FBR without the need for in vivo animal testing.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Matej Simek, Kristyna Turkova, Martin Schwarzer, Kristina Nesporova, Lukas Kubala, Martina Hermannova, Tereza Foglova, Barbora Safrankova, Martin Sindelar, Dagmar Srutkova, Sofia Chatzigeorgiou, Tereza Novotna, Tomas Hudcovic, Vladimir Velebny
Summary: Several clinical studies have shown that hyaluronan as a dietary supplement can increase skin moisture and relieve knee pain. To understand its mechanism of action, it is crucial to determine the bioavailability and in vivo fate of hyaluronan. 13C-hyaluronan combined with LC-MS analysis was used to compare the absorption and metabolism of oral hyaluronan in germ-free and conventional wild-type mice. The presence of Bacteroides spp. in the gut was found to be crucial for hyaluronan absorption.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Romana Sinova, Petra Zadnikova, Barbora Safrankova, Kristina Nesporova
Summary: This study verifies that the anti-HA antibody is not specific enough for HA and recommends using the biotinylated HA binding protein (bHABP) probe as a reliable method. The conclusions based on HA antibodies in previous studies should be reevaluated, and the future use of anti-HA antibodies should be avoided.
Meeting Abstract
Cell Biology
Vojtech Pavlik, Monika Stepanova, Kristina Nesporova, Petr Sulc, Lukas Kubala, Anna Kocurkova, Knotkova Katerina, Stepan Vondrovic, Lucie Horackova, Vladimir Velebny
WOUND REPAIR AND REGENERATION
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
