Article
Engineering, Biomedical
Qimanguli Saiding, Yiyao Chen, Juan Wang, Catarina Leite Pereira, Bruno Sarmento, Wenguo Cui, Xinliang Chen
Summary: Hernia reconstruction is a frequently performed surgical procedure that has been greatly improved by plastic surgery techniques. Surgical meshes are commonly used for abdominal wall hernia repair, but there are still challenges in mesh design and complications. This review provides a comprehensive summary of hernia surgical mesh development, including commercial meshes, prosthetic materials, and engineered prosthetics. The review also outlines future research directions for successful hernia repair solutions.
MATERIALS TODAY BIO
(2023)
Review
Surgery
Michel Prudhomme, Pascale Fabbro-Peray, Eric Rullier, Bob Occean, Martin M. Bertrand
Summary: Recent studies have shown that there is no significant difference in the rate of incisional hernia formation between the mesh and non-mesh groups at both 1 and 2-year follow ups, therefore the use of a mesh is not recommended.
Article
Biochemistry & Molecular Biology
Natasha Bokhari, Abida Yasmeen, Asif Ali, Hamad Khalid, Rong Wang, Mustehsan Bashir, Faiza Sharif
Summary: Meshes made from natural silk are knitted and coated with a blend polymer of chitosan and bacterial cellulose, using extracts from pomegranate peel, Nigella sativa seed, licorice root, and bearberry leaf. Characterization analysis shows the presence of bioactive chemicals in the extracts and the coated surface. The coated meshes have higher tensile strength, sustained release of phytochemical extracts, and promote wound/tissue healing and combat bacterial infections, making them suitable for hernia repair and fistula/cleft palate repair.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Green & Sustainable Science & Technology
Chengyong Gao, Tieling Xing, Xueni Hou, Yue Zhang, Guoqiang Chen
Summary: The improved polyester fabric printing ink enhances ink diffusion on the fabric surface by regulating intermolecular forces and ink microstructure. The LF-NMR test reveals the characteristics of main reagent solutions and ink, showing a correlation between ink viscosity and transverse relaxation time. This innovative ink has the potential to achieve green printing with environmental protection, high efficiency, and low energy consumption.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Zahra Moazzami Goudarzi, Mahnaz Soleimani, Laleh Ghasemi-Mobarakeh, Pawel Sajkiewicz, Fariborz Sharifianjazi, Amirhossein Esmaeilkhanian, Samad Khaksar
Summary: A drug delivery system based on textile substrates and nanofibers was developed in this study for controlled drug release. The obtained samples showed potential for future wound dressing applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Gastroenterology & Hepatology
Mariana Morales-Cruz, Melissa Oliveira-Cunha, Sanjay Chaudhri
Summary: This study investigated the clinical outcomes of repairing perineal hernias with prosthetic mesh through a perineal open approach. The incidence of perineal hernias in the study was 10%, and the surgical approach using a double layer prosthetic mesh had a recurrence ratio of 30% and an overall morbidity of 30% with no major complications.
COLORECTAL DISEASE
(2021)
Article
Engineering, Environmental
Nooraddein A. Ekrayem, Almahdi A. Alhwaige, Wael Elhrari, Mohamed Amer
Summary: The study developed eco-friendly polymeric spheres derived from crosslinking of chitosan (CTS) with different polyesters. The spheres showed enhanced structure and stability in aqueous media, with decreased hydrophilicity, and were effective in adsorbing lead ions (Pb2+) from aqueous solutions. The experimental data was fitted well with the Freundlich isotherm model, showing the best fit for the adsorption process.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Surgery
Anne P. Ehlers, Ryan Howard, Lia D. Delaney, Quintin Solano, Dana A. Telem
Summary: The use of mesh for small hernias is controversial. This study found that patients who had mesh placed during surgery may have a higher risk for complications, suggesting that the decision to use mesh may be driven by patient-related factors rather than evidence indicating its superiority in this population.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Chemistry, Applied
Mayyas Al-Remawi, Nisrein Jaber, Amani Elsayed, Diya Alsafadi, Khalid Abu Salah
Summary: The current study aimed to design a nanoparticulate system for encapsulating insulin and improving its stability. Nanoparticles were successfully formulated through the ionic cross-linking of chitosan with carbonate divalent anions. The findings demonstrated that the chitosan carbonate system not only maintained the stability of insulin conformation but also interacted with insulin.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Tea Kaurin, Tanja Pusic, Mirjana Curlin
Summary: This research focuses on functionalizing a standard polyester fabric with biopolymer chitosan, using alkaline hydrolysis with the addition of cationic and anionic surfactants as promoters. The study compares the compatibility of chitosan with untreated and alkali-hydrolyzed fabrics through the analysis of mechanical and physico-chemical properties. The results show that alkaline hydrolysis of polyester fabric has the best potential for functionalization with chitosan, and the addition of surfactants as promoters is not necessary in the pretreatment process phase.
Article
Multidisciplinary Sciences
Lin Zhuang, Yuanjiu Li, Wei He, Xiaodong Zhou, Yan Chen, Xiaozhong Wang, Bo Wang, Xuezhong Xu, Kejia Wu, Qiutao Zhang, Dong Xi, Yunjie Lu
Summary: This study aimed to investigate the therapeutic efficacy of programmed spatial anatomy of myopectineal orifice technique in laparoscopic total extraperitoneal hernioplasty (TEP) surgery. The results showed that the programmed spatial anatomy of the myopectineal orifice could significantly improve the treatment outcome of TEP, with reduced perioperative and postoperative complications. The findings suggest that this technique should be promoted among young physicians and basic hospitals.
SCIENTIFIC REPORTS
(2023)
Article
Polymer Science
Euigyung Jeong, Heeju Woo, Yejin' Moon, Dong Yun Lee, Minjung Jung, Young-Seak Lee, Jin-Seok Bae
Summary: This study demonstrates that self-cleaning PET fabrics with superior photocatalytic and superhydrophobic properties can be prepared using TiOF2 and HDS treatment. Practical tests show that these PET fabrics have strong anti-pollution capabilities and can self-clean in a short period of time.
Article
Engineering, Environmental
Liangyuan Qi, Liang Chen, Wei Cai, Chuanshen Wang, Bangyu Wang, Yuan Hu, Weiyi Xing
Summary: This study proposes a coating preparation strategy using solid-liquid host-guest materials to fabricate smart polyester fabrics with personal temperature management and flame retardancy. The coated polyester fabric shows desirable temperature regulation ability and excellent flame retardancy. This phase-change flame-retardant polyester fabric has huge application potentials in various personal temperature management fields.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Surgery
Emily Grimsley, Ana Capati, Adham R. Saad, Christopher DuCoin, Vic Velanovich
Summary: The study compared the outcomes of hiatal hernia repair using keyhole and starburst mesh configurations. The results showed that the starburst configuration had better outcomes in terms of postoperative dysphagia, need for esophageal dilation, and GERD symptom recurrence, with similar recurrence rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Engineering, Biomedical
Tanushree Saha, Shadi Houshyar, Satya Ranjan Sarker, Suneela Pyreddy, Chaitali Dekiwadia, Zeyad Nasa, Rajiv Padhye, Xin Wang
Summary: The study developed a novel PP mesh modified with bioactive chitosan and functionalized nanodiamond (FND) to inhibit infection and accelerate the healing process. The modified mesh showed increased hydrophilicity and cell attachment, as well as great antibacterial efficiency against Escherichia coli, suggesting a promising technique to reduce the risk of infection after surgery.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Instruments & Instrumentation
Heba M. A. Khalil, Islam A. Khalil, Asmaa K. Al-Mokaddem, Marwa Hassan, Riham A. El-Shiekh, Hesham A. Eliwa, Azza M. Tawfek, Walaa H. El-Maadawy
Summary: The encapsulation of ASH in chitosan-alginate bipolymeric nanocapsules (ASH-BPNCs) enhances its therapeutic effectiveness in the gastrointestinal tract, improving hepatoprotective and neuroprotective effects. The ASH-BPNCs also demonstrate promising biodistribution in the brain and hepatic tissues.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Suzan A. Rashed, Sherif F. Hammad, Moustafa M. Eldakak, Islam A. Khalil, Ahmed Osman
Summary: Phycocyanin, a constituent protein of Arthrospira platensis, has shown promising efficacy against cancer. In this study, the chromophore of Phycocyanin, called phycocyanobilin (PCB), was cleaved and demonstrated to have anti-cancer effects on colorectal cancer cells. Additionally, the incorporation of PCB into UiO-66 nanoparticles significantly improved its cytotoxic effects.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Yasmine Radwan, Kholoud K. Arafa, Monira G. Ghoniem, Eida S. Al-Farraj, Ibrahim M. El-Sherbiny
Summary: This study aimed to investigate the synergistic therapeutic effect of the novel combination of capsaicin and 5-fluorouracil encapsulated in lipid nanocapsules. The results showed that the developed nanoformulations had good physical stability and exhibited superior antiproliferative effect compared to the free drugs.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Mohamed El -Far, Alaa Essam, Fardous F. El-Senduny, Amira O. Abd El-Azim, Sarah Yahia, Ibrahim M. El-Sherbiny
Summary: In this study, the anticancer effect of a novel drug combination using nanoformulations of Quercetin and Ascorbyl palmitate was investigated in Ehrlich ascites carcinoma (EAC)-bearing mice. The combination treatment significantly reduced tumor growth, increased antioxidant status, and reduced lipid peroxidation. The combination also downregulated the expression of p-STAT3 and HIF-1 alpha, induced cell cycle arrest and apoptosis in EAC cells, and caused DNA damage. The combination was also superior in the destruction of the mitochondrial membrane.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mohamed Fawzi Kabil, Osama A. Badary, Frank Bier, Shaker A. Mousa, Ibrahim M. El-Sherbiny
Summary: Cancer is a major cause of death worldwide, and chemotherapy is the most commonly used treatment. However, current chemotherapeutic treatments have limitations, including lack of specificity and adverse effects. Lipid nanoparticles (LNPs) offer a promising nanocarrier system to improve drug delivery and reduce side effects, potentially leading to better therapeutic outcomes.
JOURNAL OF LIPOSOME RESEARCH
(2023)
Correction
Pharmacology & Pharmacy
Amira Mansour, Mohamed Y. Mahmoud, Alaa F. Bakr, Monira G. Ghoniem, Fatima A. Adam, Ibrahim M. El-Sherbiny
Article
Chemistry, Multidisciplinary
Mostafa Fytory, Amira Mansour, Waleed M. A. El Rouby, Ahmed A. Farghali, Xiaorong Zhang, Frank Bier, Mahmoud Abdel-Hafiez, Ibrahim M. El-Sherbiny
Summary: By grafting glycyrrhetinic acid to polyethyleneimine, a biocompatible Zr-based metal-organic framework was designed for efficient controlled drug release and selective targeting against hepatic cancer cells. The improved core-shell structure enhanced the drug loading capacity and selectivity towards tumor cells, while exhibiting minimal toxicity to normal cells. This study provides a new approach for active drug delivery and efficient cancer therapy applications.
Article
Environmental Sciences
Heba M. A. Khalil, Hanan M. A. El Henafy, Islam A. Khalil, Alaa F. Bakr, Mohamed I. Fahmy, Nancy S. Younis, Riham A. El-Shiekh
Summary: This study aimed to investigate the neuroprotective action of Hypericum perforatum L. (HP L.) and its nanoemulsion (HP.NE) against cisplatin-induced neurotoxicity. HP L. and HP.NE-treated rats showed improved motor activity and spatial working memory, enhanced antioxidant defense system, reduced pro-inflammatory cytokines levels, and increased expression of PON-3 and GPX genes associated with reduced COX-2 and TP-53 levels in the brain. These findings were confirmed by reduced expression of NF-Kappa B and increased Ki-67 levels. In conclusion, HP L. is a promising herb as an adjuvant candidate to ameliorate chemotherapeutic-induced neurotoxicity, and HP.NE has superior activity in lessening cisplatin-induced oxidative stress, inflammation, and apoptosis in brain tissue.
Article
Pharmacology & Pharmacy
Eman M. Abd-Elmonem, Amna M. A. Makky, Assem Antar, Wessam H. Abd-Elsalam, Islam A. Khalil
Summary: This study developed a new ocular drug formulation by incorporating AMO into mixed micelles, aiming to enhance the delivery of AMO to the corneal tissue. The optimal formulation F5 showed a particle size of 26.55 +/- 1.68 nm and a drug loading percentage of 7.49 +/- 0.01%. The ex vivo permeation study confirmed its corneal penetrability, and the MIC of the optimal formulation was 3 folds lower than the standard market product. In vivo study on rabbits demonstrated the biosafety and effectiveness of the optimal formulation. Overall, AMO-MMs hold promise as a corneal delivery system for the management of fungal keratitis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mona K. Younis, Yara E. Elakkad, Rasha R. Fakhr Eldeen, Isra H. Ali, Islam A. Khalil
Summary: This study aimed to develop propranolol-loaded trehalosomes as an antiproliferative agent for skin cancer treatment. A factorial design was used to determine the optimum formula, and the selected formula was characterized and evaluated. Cell studies and in silico studies were conducted to assess cytotoxicity, apoptosis, and cell cycle arrest. The results showed that the optimized formula exhibited good cytotoxicity and induced apoptosis and cell cycle arrest. In addition, in silico studies identified influential receptors in melanoma that matched the experimental results. Overall, the selected formula has great potential as an antiproliferative agent for skin cancer treatment due to the synergistic effect between the drug and the carrier.
Article
Biochemistry & Molecular Biology
Mona K. Younis, Islam A. Khalil, Nancy S. Younis, Rasha R. Fakhr Eldeen, Rana M. Abdelnaby, Reem A. Aldeeb, Amal A. Taha, Doaa H. Hassan
Summary: This study aimed to evaluate the antiproliferative effects of an aceclofenac/citronellol oil nanoemulsion on melanoma. The nanoemulsion exhibited potent cytotoxicity and pro-apoptotic effects, with a lower IC50 value compared to aceclofenac or citronellol alone. In silico studies provided insights into the molecular mechanism underlying the observed antitumor activity.
Article
Chemistry, Multidisciplinary
Sarah Yahia, Islam A. Khalil, Monira G. Ghoniem, Ibrahim M. El-Sherbiny
Summary: This work aimed to develop a functional spine unit (FSU) replacement using different technologies to mimic the structure and function of the vertebral body (VB) and intervertebral disc (IVD) and treat spinal tuberculosis (TB). 3D-printed scaffolds with different porous patterns were fabricated to replace damaged VB and IVD. The results showed excellent mechanical strength and biocompatibility of the custom-designed replacements, along with the expected prolonged release of antibiotics. These findings suggest that this drug-eluting scaffold system could be used for treating various spinal problems.
Article
Multidisciplinary Sciences
Isra H. Ali, Islam A. Khalil, Ibrahim M. El-Sherbiny
Summary: Impaired healing of diabetic ulcers is a major complication for diabetic patients. This study developed a multilayered nanofibrous wound patch with three drugs incorporated to target different phases of wound healing. The drug release profiles were studied and the patch's physicochemical and mechanical properties were assessed. In vivo tests on diabetic rat models showed successful wound healing within three weeks. Histopathological studies confirmed complete healing with proper cell regeneration.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Amira Mansour, Mostafa Fytory, Osama M. Ahmed, Fatema El-Zahraa S. Abdel Rahman, Ibrahim M. El-Sherbiny
Summary: This study developed a novel nanostructure for breast cancer treatment by loading Methotrexate (MTX) and 5-fluorouracil (Fu) into a core-shell nanocarrier. The nanostructure showed high drugs' entrapment efficiency and a pH-responsive drug release pattern. In vitro and in vivo experiments demonstrated the enhanced anticancer effect of the developed nanostructure and its ability to maintain the normal functions of vital organs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Ahmed S. Abo Dena, Mariam Dhaou, Ibrahim M. El-Sherbiny
Summary: In this study, a fluorescent molecularly imprinted polymer (FMIP) was developed for the solid-phase extraction (SPE) and fluorimetric determination of hydrochlorothiazide (HCTZ) in water. The FMIP exhibited high adsorption capacity and selectivity for HCTZ, making it suitable for easy and fast SPE of HCTZ.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)