Understanding TCR affinity, antigen specificity, and cross-reactivity to improve TCR gene-modified T cells for cancer immunotherapy

Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer

(2019) Stefan Audehm et al.   Frontiers in Immunology

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes

(2018) Marvin H. Gee et al.   CELL

TCR modifications that enhance chain pairing in gene-modified T cells can augment cross-reactivity and alleviate CD8 dependence

(2018) Timothy T. Spear et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells

(2018) Timothy T. Spear et al.   MOLECULAR THERAPY

Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro

(2018) Marvin H. Gee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability

(2018) Timothy P. Riley et al.   Nature Chemical Biology

Improving T Cell Receptor On-Target Specificity via Structure-Guided Design

(2018) Lance M. Hellman et al.   MOLECULAR THERAPY

The intersection of affinity and specificity in the development and optimization of T cell receptor based therapeutics

(2018) Timothy P. Riley et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Affinity-enhanced T-cell receptors for adoptive T-cell therapy targeting MAGE-A10: strategy for selection of an optimal candidate

(2018) Ellen C. Border et al.   OncoImmunology

A study of CDR3 loop dynamics reveals distinct mechanisms of peptide recognition by T-cell receptors exhibiting different levels of cross-reactivity

(2017) Yuko Tsuchiya et al.   IMMUNOLOGY

How an alloreactive T-cell receptor achieves peptide and MHC specificity

(2017) Yuan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer

(2017) Kendra C. Foley et al.   Molecular Therapy-Oncolytics

TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors

(2016) Timothy T. Spear et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Strategies to genetically engineer T cells for cancer immunotherapy

(2016) Timothy T. Spear et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex

(2016) Daniel T. Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability

(2016) Timothy T. Spear et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces

(2016) Timothy P. Riley et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Overcoming the toxicity hurdles of genetically targeted T cells

(2014) Monica Casucci et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Engineered T cells for cancer therapy

(2014) Carl H. June et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma

(2014) T. Chodon et al.   CLINICAL CANCER RESEARCH

Accumulation of Serial Forces on TCR and CD8 Frequently Applied by Agonist Antigenic Peptides Embedded in MHC Molecules Triggers Calcium in T Cells

(2014) S. Pryshchep et al.   JOURNAL OF IMMUNOLOGY

Specific Increase in Potency via Structure-Based Design of a TCR

(2014) Karolina Malecek et al.   JOURNAL OF IMMUNOLOGY

Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

(2014) Brian G. Pierce et al.   PLoS Computational Biology

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system

(2013) Baoyu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy

(2013) Richard A. Morgan et al.   JOURNAL OF IMMUNOTHERAPY

Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells

(2013) B. J. Cameron et al.   Science Translational Medicine

Structure-Based, Rational Design of T Cell Receptors

(2013) V. Zoete et al.   Frontiers in Immunology

Transforming binding affinities from three dimensions to two with application to cadherin clustering

(2011) Yinghao Wu et al.   NATURE

Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells

(2010) C. H. J. Lamers et al.   BLOOD

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

(2010) Maria R Parkhurst et al.   MOLECULAR THERAPY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

Transduction of Human T Cells with a Novel T-Cell Receptor Confers Anti-HCV Reactivity

(2010) Yi Zhang et al.   PLoS Pathogens

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

Relationship between CD8-dependent antigen recognition, T cell functional avidity, and tumor cell recognition

(2008) Tamson V. Moore et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Characterization of Genetically Modified T-Cell Receptors that Recognize the CEA:691-699 Peptide in the Context of HLA-A2.1 on Human Colorectal Cancer Cells

(2008) M. R. Parkhurst et al.   CLINICAL CANCER RESEARCH

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC

(2008) Jaafar N. Haidar et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS