TCR modifications that enhance chain pairing in gene-modified T cells can augment cross-reactivity and alleviate CD8 dependence

HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer

(2017) Kendra C. Foley et al.   Molecular Therapy-Oncolytics

TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors

(2016) Timothy T. Spear et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Strategies to genetically engineer T cells for cancer immunotherapy

(2016) Timothy T. Spear et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability

(2016) Timothy T. Spear et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control

(2014) Jennifer D. Stone et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TALEN-mediated editing of endogenous T-cell receptors facilitates efficient reprogramming of T lymphocytes by lentiviral gene transfer

(2014) B Berdien et al.   GENE THERAPY

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy

(2013) Richard A. Morgan et al.   JOURNAL OF IMMUNOTHERAPY

Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells

(2013) B. J. Cameron et al.   Science Translational Medicine

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

(2012) Elena Provasi et al.   NATURE MEDICINE

Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains

(2011) D H Aggen et al.   GENE THERAPY

Coexpression of the T-cell receptor constant   domain triggers tumor reactivity of single-chain TCR-transduced human T cells

(2010) R.-H. Voss et al.   BLOOD

T-Cell Receptor Gene-Modified T Cells with Shared Renal Cell Carcinoma Specificity for Adoptive T-Cell Therapy

(2010) M. Leisegang et al.   CLINICAL CANCER RESEARCH

Minimal Amino Acid Exchange in Human TCR Constant Regions Fosters Improved Function of TCR Gene-Modified T Cells

(2010) D. Sommermeyer et al.   JOURNAL OF IMMUNOLOGY

Targeting the epidermal growth factor receptor (HER) family by T cell receptor gene-modified T lymphocytes

(2010) Peter Meyerhuber et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Of Mice, Not Men: No Evidence for Graft-versus-Host Disease in Humans Receiving T-Cell Receptor–Transduced Autologous T Cells

(2010) Steven A Rosenberg   MOLECULAR THERAPY

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

(2010) Maria R Parkhurst et al.   MOLECULAR THERAPY

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

(2010) Gavin M Bendle et al.   NATURE MEDICINE

Mixed T cell receptor dimers harbor potentially harmful neoreactivity

(2010) M. M. van Loenen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

Improved Expression and Reactivity of Transduced Tumor-Specific TCRs in Human Lymphocytes by Specific Silencing of Endogenous TCR

(2009) S. Okamoto et al.   CANCER RESEARCH