Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers

Mutational processes shape the landscape of TP53 mutations in human cancer

(2018) Andrew O. Giacomelli et al.   NATURE GENETICS

The rare nonsense mutation in p53 triggers alternative splicing to produce a protein capable of inducing apoptosis

(2017) Evgeny M. Makarov et al.   PLoS One

Profiling cancer gene mutations in longitudinal epithelial ovarian cancer biopsies by targeted next-generation sequencing: a retrospective study

(2015) L. Beltrame et al.   ANNALS OF ONCOLOGY

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

TP53 hot spot mutations in ovarian cancer: Selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas

(2015) Brandon-Luke L. Seagle et al.   GYNECOLOGIC ONCOLOGY

Whole–genome characterization of chemoresistant ovarian cancer

(2015) Ann-Marie Patch et al.   NATURE

TP53mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer

(2015) Jeremy Chien et al.   NUCLEIC ACIDS RESEARCH

Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis

(2015) Roland F. Schwarz et al.   PLOS MEDICINE

Mutants TP53 p.R273H and p.R273C but not p.R273G Enhance Cancer Cell Malignancy

(2014) Jie Li et al.   HUMAN MUTATION

Molecular Characterization of an Intact p53 Pathway Subtype in High-Grade Serous Ovarian Cancer

(2014) Takahide Hayano et al.   PLoS One

Deficiency in asparagine synthetase expression in rectal cancers receiving concurrent chemoradiotherapy: negative prognostic impact and therapeutic relevance

(2014) Ching-Yih Lin et al.   TUMOR BIOLOGY

Asparagine synthetase is an independent predictor of surgical survival and a potential therapeutic target in hepatocellular carcinoma

(2013) B Zhang et al.   BRITISH JOURNAL OF CANCER

Not all p53 gain-of-function mutants are created equal

(2013) S S Mello et al.   CELL DEATH AND DIFFERENTIATION

High Levels of Genomic Aberrations in Serous Ovarian Cancers Are Associated with Better Survival

(2013) Lars O. Baumbusch et al.   PLoS One

Clinical Relevance of Gain-Of-Function Mutations of p53 in High-Grade Serous Ovarian Carcinoma

(2013) Hyo Jeong Kang et al.   PLoS One

Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome

(2012) Z. C. Wang et al.   CLINICAL CANCER RESEARCH

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

The Genomic Landscape of TP53 and p53 Annotated High Grade Ovarian Serous Carcinomas from a Defined Founder Population Associated with Patient Outcome

(2012) Paulina M. Wojnarowicz et al.   PLoS One

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Prognostic Significance of Truncating TP53 Mutations in Head and Neck Squamous Cell Carcinoma

(2011) M. Lindenbergh-van der Plas et al.   CLINICAL CANCER RESEARCH

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells

(2010) Dong-Jun Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutant p53 R248Q but not R248W enhances in vitro invasiveness of human lung cancer NCI-H1299 cells

(2010) Kazuhito Yoshikawa et al.   BIOMEDICAL RESEARCH-TOKYO

Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

(2010) Ahmed Ashour Ahmed et al.   JOURNAL OF PATHOLOGY

Ovarian Low-grade and High-grade Serous Carcinoma

(2009) Russell Vang et al.   ADVANCES IN ANATOMIC PATHOLOGY

Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome

(2008) R. W. Tothill et al.   CLINICAL CANCER RESEARCH