Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation

RNA interference-mediated knockdown of SIRT1 and/or SIRT2 in melanoma: Identification of downstream targets by large-scale proteomics analysis

(2018) Melissa J. Wilking-Busch et al.   Journal of Proteomics

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance

(2018) Shang Yao et al.   SEMINARS IN CANCER BIOLOGY

Epidermal Growth Factor Receptor Family Inhibition Identifies P38 Mitogen-activated Protein Kinase as a Potential Therapeutic Target in Bladder Cancer

(2018) Regina Mora Vidal et al.   UROLOGY

The FOXM1–ABCC5 axis contributes to paclitaxel resistance in nasopharyngeal carcinoma cells

(2017) Youxiang Hou et al.   Cell Death & Disease

Inhibition of eEF-2 kinase sensitizes human nasopharyngeal carcinoma cells to lapatinib-induced apoptosis through the Src and Erk pathways

(2016) Lin Liu et al.   BMC CANCER

Capecitabine and lapatinib for the first-line treatment of metastatic/recurrent head and neck squamous cell carcinoma

(2016) Jared M. Weiss et al.   CANCER

HER Specific TKIs Exert Their Antineoplastic Effects on Breast Cancer Cell Lines through the Involvement of STAT5 and JNK

(2016) Daphne Gschwantler-Kaulich et al.   PLoS One

Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial

(2015) Jean-Pascal H Machiels et al.   LANCET ONCOLOGY

Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin

(2014) JINGJING WU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Overexpression of FOXM1 is associated with metastases of nasopharyngeal carcinoma

(2014) Lizhu Jiang et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer

(2013) Mattaka Khongkow et al.   CARCINOGENESIS

Stat3 Inhibitor Stattic Exhibits Potent Antitumor Activity and Induces Chemo- and Radio-Sensitivity in Nasopharyngeal Carcinoma

(2013) Yunbao Pan et al.   PLoS One

A Global View of the Oncogenic Landscape in Nasopharyngeal Carcinoma: An Integrated Analysis at the Genetic and Expression Levels

(2012) Chunfang Hu et al.   PLoS One

C-KIT overexpression and mutation in nasopharyngeal carcinoma cell lines and reactivity of Imatinib on these cell lines

(2012) Pei-Yu Huang et al.   Chinese Journal of Cancer

SIRT2 activity is required for the survival of C6 glioma cells

(2011) Xin He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FOXO and FOXM1 in Cancer: The FOXO-FOXM1 Axis Shapes the Outcome of Cancer Chemotherapy

(2011) Miranda S.C. Wilson et al.   CURRENT DRUG TARGETS

The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells

(2011) L. Dan et al.   HAEMATOLOGICA

Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin

(2011) Ka-Kei Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and prognosis of FOXO3a and HIF-1α in nasopharyngeal carcinoma

(2011) Zhu Shou et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer

(2011) C T Karadedou et al.   ONCOGENE

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation

(2011) F Wang et al.   ONCOGENE

The Extending Network of FOXO Transcriptional Target Genes

(2010) Kristan E. van der Vos et al.   ANTIOXIDANTS & REDOX SIGNALING

FoxM1 Mediates Resistance to Herceptin and Paclitaxel

(2010) Janai R. Carr et al.   CANCER RESEARCH

Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer

(2010) Yolanda Olmos et al.   DRUG RESISTANCE UPDATES

Anti-invasion, anti-proliferation and anoikis-sensitization activities of lapatinib in nasopharyngeal carcinoma cells

(2010) Vivian Wai Yan Lui et al.   INVESTIGATIONAL NEW DRUGS

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response

(2009) Brigette B.Y. Ma et al.   INVESTIGATIONAL NEW DRUGS

Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer

(2009) U. B. McGovern et al.   MOLECULAR CANCER THERAPEUTICS