The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice

Sensitization of Human Liver Cells Towards Fas‐Mediated Apoptosis by the Metabolically Activated Pyrrolizidine Alkaloid Lasiocarpine

(2019) Johanna Ebmeyer et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine

(2019) Johanna Ebmeyer et al.   FOOD AND CHEMICAL TOXICOLOGY

Structure-dependent induction of apoptosis by hepatotoxic pyrrolizidine alkaloids in the human hepatoma cell line HepaRG: Single versus repeated exposure

(2018) Julia Waizenegger et al.   FOOD AND CHEMICAL TOXICOLOGY

Risk assessment of pyrrolizidine alkaloids in food of plant and animal origin

(2018) Birgit Dusemund et al.   FOOD AND CHEMICAL TOXICOLOGY

Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells

(2018) Johanna Ebmeyer et al.   CHEMICO-BIOLOGICAL INTERACTIONS

In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice

(2016) Raymond Reif et al.   ARCHIVES OF TOXICOLOGY

Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity

(2016) Mengbi Yang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Interim relative potency factors for the toxicological risk assessment of pyrrolizidine alkaloids in food and herbal medicines

(2016) Karl-Heinz Merz et al.   TOXICOLOGY LETTERS

Bile canalicular dynamics in hepatocyte sandwich cultures

(2015) Raymond Reif et al.   ARCHIVES OF TOXICOLOGY

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

(2015) Colin J. Henderson et al.   BIOCHEMICAL JOURNAL

Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis

(2015) Claudia Luckert et al.   TOXICOLOGY IN VITRO

Metabolomic and Genomic Evidence for Compromised Bile Acid Homeostasis by Senecionine, a Hepatotoxic Pyrrolizidine Alkaloid

(2014) Aizhen Xiong et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolic Activation of Pyrrolizidine Alkaloids: Insights into the Structural and Enzymatic Basis

(2014) Jianqing Ruan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Determination of pyrrolizidine alkaloids in tea, herbal drugs and honey

(2014) Dorina Bodi et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Definitive diagnosis of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids

(2011) Hong GAO et al.   Journal of Digestive Diseases