Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

Intestinal label-retaining cells are secretory precursors expressing Lgr5

(2013) Simon J. A. Buczacki et al.   NATURE

Role of mammary epithelial and stromal P450 enzymes in the clearance and metabolic activation of 7,12-dimethylbenz(a)anthracene in mice

(2012) Yang Lin et al.   TOXICOLOGY LETTERS

Methodologies for Investigating Drug Metabolism at the Early Drug Discovery Stage: Prediction of Hepatic Drug Clearance and P450 Contribution

(2011) Chie Emoto et al.   CURRENT DRUG METABOLISM

Effect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null Mice

(2011) V. M. Arlt et al.   DRUG METABOLISM AND DISPOSITION

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

(2011) H Nikki March et al.   NATURE GENETICS

Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

(2011) Kateřina Levová et al.   TOXICOLOGICAL SCIENCES

Loss of Indian Hedgehog Activates Multiple Aspects of a Wound Healing Response in the Mouse Intestine

(2010) Willemijn A. van Dop et al.   GASTROENTEROLOGY

Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling

(2010) Jennie L Conroy et al.   NATURE NEUROSCIENCE

Identification of Cytochrome P450 Isoforms Involved in the Metabolism of Paroxetine and Estimation of Their Importance for Human Paroxetine Metabolism Using a Population-Based Simulator

(2009) J. Jornil et al.   DRUG METABOLISM AND DISPOSITION

Mutated K-rasAsp12promotes tumourigenesis inApcMinmice more in the large than the small intestines, with synergistic effects between K-rasandWntpathways

(2009) Feijun Luo et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

(2009) K. Schmidt et al.   MOLECULAR AND CELLULAR BIOLOGY

E2f1–3 switch from activators in progenitor cells to repressors in differentiating cells

(2009) Jean-Leon Chong et al.   NATURE

Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine

(2009) Boris Y. Shorning et al.   PLoS One

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

(2008) Robert D. Finn et al.   BIOCHEMICAL JOURNAL

Lkb1 Deficiency Causes Prostate Neoplasia in the Mouse

(2008) H. B. Pearson et al.   CANCER RESEARCH

Deletion of the NADPH-Cytochrome P450 Reductase Gene in Cardiomyocytes Does Not Protect Mice against Doxorubicin-Mediated Acute Cardiac Toxicity

(2008) C. Fang et al.   DRUG METABOLISM AND DISPOSITION

An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine

(2008) Q.-Y. Zhang et al.   DRUG METABOLISM AND DISPOSITION

Defining thein VivoRole for Cytochromeb5in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochromeb5

(2008) Robert D. Finn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

(2008) Victoria Marsh et al.   NATURE GENETICS

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH:Cytochrome P450 reductase null mouse

(2007) Marie Stiborová et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY