STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma

Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view

(2016) Marcos Roberto de Oliveira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling

(2016) Jasmina Paluncic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Resveratrol as a Potential Therapeutic Candidate for the Treatment and Management of Alzheimer';s Disease

(2016) Nady Braidy et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The role of natural polyphenols in cell signaling and cytoprotection against cancer development

(2016) Hanna Lewandowska et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol and Alzheimer’s Disease: Mechanistic Insights

(2016) Touqeer Ahmed et al.   MOLECULAR NEUROBIOLOGY

Epigallocatechin gallate and mitochondria—A story of life and death

(2016) Marcos Roberto de Oliveira et al.   PHARMACOLOGICAL RESEARCH

Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma

(2016) Hui-Hui Cao et al.   Scientific Reports

Inhibition of STAT3/cyclinD1 pathway promotes chemotherapeutic sensitivity of colorectal caner

(2015) Ancheng Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells

(2015) H.-S. Seo et al.   BIOSCIENCE REPORTS

Targeting drivers of melanoma with synthetic small molecules and phytochemicals

(2015) Leah Ray Strickland et al.   CANCER LETTERS

Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy

(2015) Joaquim Bosch-Barrera et al.   CANCER TREATMENT REVIEWS

Flavonoids and Dementia: An Update

(2015) I.E. Orhan et al.   CURRENT MEDICINAL CHEMISTRY

Nivolumab and pembrolizumab as immune-modulating monoclonal antibodies targeting the PD-1 receptor to treat melanoma

(2015) Elnaz Faghfuri et al.   Expert Review of Anticancer Therapy

Role of quercetin as an alternative for obesity treatment: You are what you eat!

(2015) Seyed Fazel Nabavi et al.   FOOD CHEMISTRY

Molecular mechanisms underlying anticancer effects of myricetin

(2015) Kasi Pandima Devi et al.   LIFE SCIENCES

Natural products with therapeutic potential in melanoma metastasis

(2015) A. AlQathama et al.   NATURAL PRODUCT REPORTS

Potential of butein, a tetrahydroxychalcone to obliterate cancer

(2015) Ganesan Padmavathi et al.   PHYTOMEDICINE

Molecular drivers of cellular metabolic reprogramming in melanoma

(2015) Cecilie Abildgaard et al.   TRENDS IN MOLECULAR MEDICINE

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

(2014) Subash C. Gupta et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway

(2014) X. Li et al.   ARCHIVES OF TOXICOLOGY

Luteolin Arrests Cell Cycling, Induces Apoptosis and Inhibits the JAK/STAT3 Pathway in Human Cholangiocarcinoma Cells

(2014) Ploypailin Aneknan et al.   Asian Pacific Journal of Cancer Prevention

Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling

(2014) Thomas A. Mace et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Role of Natural Phenolic Compounds in Cancer Chemoprevention via Regulation of the Cell Cycle

(2014) Samineh Jafari et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

819: Anti-migratory and cytotoxic properties of medicinal plants against melanoma

(2014) A. Alqathama et al.   EUROPEAN JOURNAL OF CANCER

Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway

(2014) Meijuan Zou et al.   MOLECULAR CARCINOGENESIS

Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis

(2014) Dimiter B. Avtanski et al.   Molecular Oncology

Nanomedicine therapeutic approaches to overcome cancer drug resistance

(2013) Janet L. Markman et al.   ADVANCED DRUG DELIVERY REVIEWS

Optimal Management of Metastatic Melanoma: Current Strategies and Future Directions

(2013) Marta Batus et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling

(2013) Hui-Hui Cao et al.   BIOCHEMICAL PHARMACOLOGY

Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth

(2013) M.-H. Lee et al.   Cancer Prevention Research

p42/p44 MAPK-mediated Stat3Ser727 phosphorylation is required for progestin-induced full activation of Stat3 and breast cancer growth

(2013) Mercedes Tkach et al.   ENDOCRINE-RELATED CANCER

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

(2013) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

A potential role for resveratrol as a radiation sensitizer for melanoma treatment

(2013) Yujiang Fang et al.   JOURNAL OF SURGICAL RESEARCH

Efficacy and side effects of dacarbazine in comparison with temozolomide in the treatment of malignant melanoma

(2013) Fatemeh Teimouri et al.   MELANOMA RESEARCH

Procyanidin B2 3,3″-di-O-gallate, a Biologically Active Constituent of Grape Seed Extract, Induces Apoptosis in Human Prostate Cancer Cells Via Targeting NF-κB, Stat3, and AP1 Transcription Factors

(2013) Alpna Tyagi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Skin melanocytes: biology and development

(2013) Mirosława Cichorek et al.   Postepy Dermatologii i Alergologii

Antioxidants: Friends or foe in prevention or treatment of cancer: The debate of the century

(2013) Soodabeh Saeidnia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1

(2012) Subash C. Gupta et al.   BIOCHEMICAL PHARMACOLOGY

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration

(2012) Jonathan Michaud-Levesque et al.   EXPERIMENTAL CELL RESEARCH

Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway

(2012) Sylvie Lamy et al.   EXPERIMENTAL CELL RESEARCH

Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines

(2012) Matthew A. Bill et al.   PLoS One

Calpain/SHP-1 Interaction by Honokiol Dampening Peritoneal Dissemination of Gastric Cancer in nu/nu Mice

(2012) Shing Hwa Liu et al.   PLoS One

Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3

(2012) Jin Fu et al.   PLoS One

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

(2012) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effect of quercetin against sodium fluoride induced oxidative stress in rat's heart

(2012) Seyed Fazel Nabavi et al.   Food & Function

The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines

(2011) Stacey L Fossey et al.   BMC CANCER

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives

(2011) Chia-Jui Weng et al.   CANCER TREATMENT REVIEWS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Natural Products as Anti-Invasive and Anti-Metastatic Agents

(2011) Y.-L. Jiang et al.   CURRENT MEDICINAL CHEMISTRY

In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue

(2011) Seyed Mohammad Nabavi et al.   FOOD CHEMISTRY

Hypoxia-inducible Factor-1α Enhances Haptoglobin Gene Expression by Improving Binding of STAT3 to the Promoter

(2011) Mi-Kyung Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis

(2011) Yi-Ping Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1

(2011) Peramaiyan Rajendran et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cardamonin suppresses nitric oxide production via blocking the IFN-γ/STAT pathway in endotoxin-challenged peritoneal macrophages of ICR mice

(2011) Amane Takahashi et al.   LIFE SCIENCES

Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis

(2011) Nam Joo Kang et al.   PHARMACOLOGY & THERAPEUTICS

Botanicals for the prevention and treatment of cutaneous melanoma

(2011) Deeba N. Syed et al.   Pigment Cell & Melanoma Research

STAT3 Knockdown Reduces Pancreatic Cancer Cell Invasiveness and Matrix Metalloproteinase-7 Expression in Nude Mice

(2011) Hai dong Li et al.   PLoS One

Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture

(2010) Valerie Trapp et al.   ANGIOGENESIS

Green tea prevents non-melanoma skin cancer by enhancing DNA repair

(2010) Santosh K. Katiyar   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells

(2010) Souichi Nakashima et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Quercetin abrogates chemoresistance in melanoma cells by modulating ΔNp73

(2010) Thilakavathy Thangasamy et al.   BMC CANCER

Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer

(2010) Gagan Deep et al.   CANCER AND METASTASIS REVIEWS

Curcumin Inhibits Constitutive STAT3 Phosphorylation in Human Pancreatic Cancer Cell lines and Downregulation of Survivin/BIRC5 Gene Expression

(2010) W. Glienke et al.   CANCER INVESTIGATION

Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells

(2010) L. Lin et al.   CANCER RESEARCH

Dietary Curcumin Attenuates Glioma Growth in a Syngeneic Mouse Model by Inhibition of the JAK1,2/STAT3 Signaling Pathway

(2010) J. Weissenberger et al.   CLINICAL CANCER RESEARCH

Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells

(2010) Grace Tak Yi Lau et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cellular origin and developmental mechanisms during the formation of skin melanocytes

(2010) Patrik Ernfors   EXPERIMENTAL CELL RESEARCH

Resveratrol induces cell-cycle disruption and apoptosis in chemoresistant B16 melanoma

(2010) Grégory Gatouillat et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

(2010) M. H. Zaki et al.   JOURNAL OF IMMUNOLOGY

Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells

(2010) Marina Pisano et al.   Molecular Cancer

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

(2010) Matthew A Bill et al.   Molecular Cancer

Genetic factors in chronic inflammation: Single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population

(2010) Lynnette R. Ferguson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

(2010) Laura Bravo   NUTRITION REVIEWS

Apigenin: A Promising Molecule for Cancer Prevention

(2010) Sanjeev Shukla et al.   PHARMACEUTICAL RESEARCH

Role of STAT3 in In Vitro Transformation Triggered by TRK Oncogenes

(2010) Claudia Miranda et al.   PLoS One

Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy

(2010) R R Ruela-de-Sousa et al.   Cell Death & Disease

Chemistry and Biochemistry of Dietary Polyphenols

(2010) Rong Tsao   Nutrients

Epidemiology of invasive cutaneous melanoma

(2009) R. M. MacKie et al.   ANNALS OF ONCOLOGY

Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms

(2009) Mohammad Athar et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: Their inhibition by curcumin

(2009) Ji Hye Seo et al.   CANCER LETTERS

Growth Inhibition and Regression of Lung Tumors by Silibinin: Modulation of Angiogenesis by Macrophage-Associated Cytokines and Nuclear Factor- B and Signal Transducers and Activators of Transcription 3

(2009) A. Tyagi et al.   Cancer Prevention Research

Silibinin Suppresses Growth of Human Prostate Carcinoma PC-3 Orthotopic Xenograft via Activation of Extracellular Signal-Regulated Kinase 1/2 and Inhibition of Signal Transducers and Activators of Transcription Signaling

(2009) R. P. Singh et al.   CLINICAL CANCER RESEARCH

Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice

(2009) Monica Musteanu et al.   GASTROENTEROLOGY

Stat3 promotes directional cell migration by regulating Rac1 activity via its activator  PIX

(2009) T. S. Teng et al.   JOURNAL OF CELL SCIENCE

Final Version of 2009 AJCC Melanoma Staging and Classification

(2009) Charles M. Balch et al.   JOURNAL OF CLINICAL ONCOLOGY

Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines

(2009) M. A. Bill et al.   MOLECULAR CANCER THERAPEUTICS

An Anticancer Effect of Curcumin Mediated by Down-Regulating Phosphatase of Regenerating Liver-3 Expression on Highly Metastatic Melanoma Cells

(2009) L. Wang et al.   MOLECULAR PHARMACOLOGY

Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival

(2008) Geoffrey E. Johnson et al.   APOPTOSIS

Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation

(2008) Megumi Funakoshi-Tago et al.   BIOCHEMICAL PHARMACOLOGY

Multitargeted therapy of cancer by silymarin

(2008) Kumaraguruparan Ramasamy et al.   CANCER LETTERS

Multi-targeted therapy of cancer by genistein

(2008) Sanjeev Banerjee et al.   CANCER LETTERS

Myricetin directly targets JAK1 to inhibit cell transformation

(2008) Takuma Kumamoto et al.   CANCER LETTERS

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Quercetin: potentials in the prevention and therapy of disease

(2008) Stephan C Bischoff   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

(2008) N. de la Iglesia et al.   GENES & DEVELOPMENT

Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-κB and STAT3 pathways in Hodgkin's lymphoma cells

(2008) Gerardo G. Mackenzie et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

(2008) Sonia Ramos   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol addiction: To die or not to die

(2008) Mehdi Shakibaei et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Butein Suppresses Constitutive and Inducible Signal Transducer and Activator of Transcription (STAT) 3 Activation and STAT3-Regulated Gene Products through the Induction of a Protein Tyrosine Phosphatase SHP-1

(2008) M. K. Pandey et al.   MOLECULAR PHARMACOLOGY

Understanding Signaling Cascades in Melanoma

(2008) Pablo Lopez-Bergami et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

The function of Stat3 in tumor cells and their microenvironment

(2008) Bernd Groner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

SOCS regulation of the JAK/STAT signalling pathway

(2008) Ben A. Croker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression

(2007) Vladimir N. Ivanov et al.   EXPERIMENTAL CELL RESEARCH

Cell cycle control as a basis for cancer chemoprevention through dietary agents

(2007) Syed Musthapa Meeran   Frontiers in Bioscience-Landmark

STAT3: A critical transcription activator in angiogenesis

(2007) Zhong Chen et al.   MEDICINAL RESEARCH REVIEWS

Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells

(2007) Wei-Jiunn Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY