Position-effect variegation revisited: HUSHing up heterochromatin in human cells

HIV-1 Integration Landscape during Latent and Active Infection

(2015) Lillian B. Cohn et al.   CELL

MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition

(2015) L. Sun et al.   EMBO REPORTS

Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of α-globin transgene variegation

(2015) Anabel Sorolla et al.   GENOMICS

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

(2015) Simon J. Elsässer et al.   NATURE

Nuclear architecture dictates HIV-1 integration site selection

(2015) Bruna Marini et al.   NATURE

Sound of silence: the properties and functions of repressive Lys methyltransferases

(2015) Chiara Mozzetta et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

(2015) I. A. Tchasovnikarova et al.   SCIENCE

Restricted epigenetic inheritance of H3K9 methylation

(2015) P. N. C. B. Audergon et al.   SCIENCE

Constitutive heterochromatin formation and transcription in mammals

(2015) Nehmé Saksouk et al.   Epigenetics & Chromatin

Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells

(2015) Asun Monfort et al.   Cell Reports

Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

(2015) Benjamin Rauwel et al.   eLife

The bromodomain: From epigenome reader to druggable target

(2014) Roberto Sanchez et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Genetic Exploration of the Exit from Self-Renewal Using Haploid Embryonic Stem Cells

(2014) Martin Leeb et al.   Cell Stem Cell

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

(2014) Patrick Essletzbichler et al.   GENOME RESEARCH

Genome methylation in D. melanogaster is found at specific short motifs and is independent of DNMT2 activity

(2014) S. Takayama et al.   GENOME RESEARCH

Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1

(2014) Janet D. Siliciano et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development

(2014) Sarah K. Harten et al.   MAMMALIAN GENOME

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons

(2014) Frank M. J. Jacobs et al.   NATURE

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Persistence by proliferation?

(2014) D. Margolis et al.   SCIENCE

Epigenetic inheritance uncoupled from sequence-specific recruitment

(2014) K. Ragunathan et al.   SCIENCE

Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection

(2014) T. A. Wagner et al.   SCIENCE

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

(2014) F. Maldarelli et al.   SCIENCE

Chromatin Position Effects Assayed by Thousands of Reporters Integrated in Parallel

(2013) Waseem Akhtar et al.   CELL

KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions

(2013) Angelo Lupo et al.   CURRENT GENOMICS

De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET

(2013) H. M. Rowe et al.   DEVELOPMENT

No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations

(2013) Neil A. Youngson et al.   MAMMALIAN GENOME

Histone lysine demethylases as targets for anticancer therapy

(2013) Jonas W. Højfeldt et al.   NATURE REVIEWS DRUG DISCOVERY

HIV latency and integration site placement in five cell-based models

(2013) Scott Sherrill-Mix et al.   Retrovirology

The Use of Mouse Models to Study Epigenetics

(2013) M. Blewitt et al.   Cold Spring Harbor Perspectives in Biology

Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila

(2013) S. C. R. Elgin et al.   Cold Spring Harbor Perspectives in Biology

Haploid Genetic Screens Identify an Essential Role for PLP2 in the Downregulation of Novel Plasma Membrane Targets by Viral E3 Ubiquitin Ligases

(2013) Richard T. Timms et al.   PLoS Pathogens

A Unique SUMO-2-Interacting Motif within LANA Is Essential for KSHV Latency

(2013) Qiliang Cai et al.   PLoS Pathogens

An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse

(2013) Lucia Daxinger et al.   GENOME BIOLOGY

Combinatorial complexity in chromatin structure and function: revisiting the histone code

(2012) Oliver J Rando   CURRENT OPINION IN GENETICS & DEVELOPMENT

Structural biology of the chromodomain: Form and function

(2012) Joel C. Eissenberg   GENE

Fluorescence-Based Phenotypic Selection Allows Forward Genetic Screens in Haploid Human Cells

(2012) Lidia M. Duncan et al.   PLoS One

Chromatin insulator elements: establishing barriers to set heterochromatin boundaries

(2012) Gráinne Barkess et al.   Epigenomics

Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells

(2011) Ulrich Elling et al.   Cell Stem Cell

Coevolution of retroelements and tandem zinc finger genes

(2011) J. H. Thomas et al.   GENOME RESEARCH

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

(2011) Lars Hillringhaus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KAP1 Protein: An Enigmatic Master Regulator of the Genome

(2011) Sushma Iyengar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights for MPP8 Chromodomain Interaction with Histone H3 Lysine 9: Potential Effect of Phosphorylation on Methyl-Lysine Binding

(2011) Yanqi Chang et al.   JOURNAL OF MOLECULAR BIOLOGY

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Derivation of haploid embryonic stem cells from mouse embryos

(2011) Martin Leeb et al.   NATURE

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing

(2011) Jan E Carette et al.   NATURE BIOTECHNOLOGY

Structural Basis for Specific Binding of Human MPP8 Chromodomain to Histone H3 Methylated at Lysine 9

(2011) Jing Li et al.   PLoS One

Mammalian Su(var) Genes in Chromatin Control

(2010) Barna D. Fodor et al.   Annual Review of Cell and Developmental Biology

Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion

(2010) Kenji Kokura et al.   EMBO JOURNAL

KAP1 controls endogenous retroviruses in embryonic stem cells

(2010) Helen M. Rowe et al.   NATURE

Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET

(2010) Toshiyuki Matsui et al.   NATURE

Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise

(2010) Nadia C Whitelaw et al.   GENOME BIOLOGY

HIV integration site distributions in resting and activated CD4+ T cells infected in culture

(2009) Troy Brady et al.   AIDS

Kruppel-Associated Box Domain-Associated Protein-1 as a Latency Regulator for Kaposi's Sarcoma-Associated Herpesvirus and Its Modulation by the Viral Protein Kinase

(2009) P.-C. Chang et al.   CANCER RESEARCH

Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development

(2009) Anne S. Soehn et al.   GENESIS

Multiple SET Methyltransferases Are Required to Maintain Normal Heterochromatin Domains in the Genome of Drosophila melanogaster

(2009) B. Brower-Toland et al.   GENETICS

Embryonic stem cells use ZFP809 to silence retroviral DNAs

(2009) Daniel Wolf et al.   NATURE

Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2

(2009) Sameer Phalke et al.   NATURE GENETICS

Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

(2009) J. E. Carette et al.   SCIENCE

Temporal Dynamics of Cytomegalovirus Chromatin Assembly in Productively Infected Human Cells

(2008) A. Nitzsche et al.   JOURNAL OF VIROLOGY

SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation

(2008) Marnie E Blewitt et al.   NATURE GENETICS

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS

A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development

(2008) Alyson Ashe et al.   GENOME BIOLOGY