Article
Food Science & Technology
Jiayu Liu, Qi Liu, Jiahui Han, Jiayu Feng, Tianmin Guo, Zhiman Li, Fenyi Min, Ruyi Jin, Xiaoli Peng
Summary: The study found that PAT can cause mitochondrial oxidative phosphorylation dysfunction and excessive ROS production in HEK293 cells, while NAC can improve cell survival by clearing excess ROS, modulating gene and protein expression of mitochondrial respiratory chain complexes.
Article
Materials Science, Ceramics
Huaxin Li, Takaaki Koyanagi, Caen Ang, Yutai Katoh
Summary: The study successfully demonstrated the joining of SiC materials at relatively low temperature through the electric current-assisted joining (ECAJ) method. Enhancing the current passage achieved the joining of low-resistivity grade, nitrogen doped beta-SiC; rapid crystal growth of textured SiC was found at the interface when joining at higher temperatures.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Kejie Li, Zhanqi Dong, Feifan Dong, Zhigang Hu, Liang Huang, Jie Wang, Peng Chen, Cheng Lu, Minhui Pan
Summary: Apoptosis is crucial for the normal growth, development, and immunity defense of living organisms. Viral infection triggers apoptosis in infected cells, but viruses have developed countermeasures to inhibit apoptosis in host cells. The study focuses on investigating the mechanism of how IAP2 induces apoptosis as well as the potential for creating resistant material through the knockout of BmNPV iap2.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Mohammad Mahdevar, Jafar Vatandoost, Farzad Seyed Forootan, Abbas Kiani-Esfahani, Maryam Esmaeili, Maryam Peymani, Hamid Tavakkoli, Ali Osmay Gure, Mohammad Hossein Nasr Esfahani, Kamran Ghaedi
Summary: The study found that lncRNA SRA is dysregulated in CRC tissue, acting as an oncogene through the OXPHOS pathway and serving as a potential biomarker for identifying CRC subtype with KRAS mutations. KRAS mutant samples had the highest SRA1 expression level. Therefore, lncRNA SRA might be a therapeutic target to inhibit cell proliferation in CRC.
Letter
Oncology
Wonhyoung Seo, Seungyeul Yoo, Yi Zhong, Sang-Hee Lee, Soo-Yeon Woo, Hee-Seon Choi, Minho Won, Taylor Roh, Sang Min Jeon, Kyeong Tae Kim, Prashanta Silwal, Min Joung Lee, Jun Young Heo, Nathan Lawlor, Sup Kim, Dongjun Lee, Jin-Man Kim, Ik-Chan Song, Jun Zhu, Eun-Kyeong Jo
Summary: In this study, the researchers investigated the oncogenic functions of ERR alpha in AML and found that it is a key regulator of mtOXPHOS in AML cells. The increased ERR alpha level was associated with worse clinical outcomes in AML patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qingyu Luo, Xiaowei Wu, Pengfei Zhao, Yabing Nan, Wan Chang, Xiaolin Zhu, Dan Su, Zhihua Liu
Summary: The study reveals the central role of OTUD1 in activating both caspase-independent and caspase-dependent apoptotic signaling by deubiquitinating AIF at specific sites, disrupting mitochondrial structure and enhancing DNA-binding ability.
Article
Biochemistry & Molecular Biology
Yuksel Ogunc Kececi, Zerrin Incesu
Summary: This study found that despite the metabolic regulation by HIF-1 alpha, oxidative phosphorylation is still functional in a hypoxic aglycemic environment. This is important for determining targets for therapeutic intervention.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Rui Jia, Yin Dong, Yiran Hou, Wenrong Feng, Bing Li, Jian Zhu
Summary: Stocking density is an important factor affecting productivity in aquaculture, and high stocking density can cause stress for aquatic animals. This study examined the effects of stocking densities on oxidative stress and energy metabolism in the gills of Cherax quadricarinatus under rice-crayfish farming. The results showed that high stocking density led to higher levels of oxidative stress markers and dysregulation of energy metabolism. Transcriptomic and pathway analyses further supported these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Parasitology
Xiaohong Yang, Ningmei Wang, Shuguang Ren, Yuhong Hu, Han Wang, Aimeng Ji, Lihui Cao, Mengxue Li, Jingze Liu, Hui Wang
Summary: This study used quantitative proteomics to investigate the molecular mechanisms of heart damage and self-repair after B. microti infection. The results revealed that proteins involved in coagulation, apoptosis, oxidative phosphorylation, and ribosomes are implicated in the damage and self-repair process. These findings provide valuable insights into the causes of heart disease induced by Babesia infection, and offer potential targets for novel drug development and targeted therapies.
PARASITES & VECTORS
(2022)
Review
Biochemistry & Molecular Biology
Chenbin Bian, Zhuangzhuang Zheng, Jing Su, Huanhuan Wang, Sitong Chang, Ying Xin, Xin Jiang
Summary: Radiotherapy failure and poor tumor prognosis are mainly caused by radioresistance. The relationship and mechanisms between mitochondrial metabolism and cancer radioresistance are not fully understood. However, mitochondria play a crucial role in regulating various biological reactions and influencing the radiation effects of malignancies. Therefore, targeting mitochondrial signaling pathways for the development of novel anticancer drugs holds promise.
Article
Physiology
M. E. Giordano, G. Udayan, M. R. Guascito, A. R. De Bartolomeo, A. Carlino, M. Conte, D. Contini, M. G. Lionetto
Summary: This study aimed to investigate the cytotoxic effects of PM10 on A549 cells and the cellular mechanisms underlying the induction of AVD and oxidative stress. The results showed that winter PM10 samples with high PM10 value and organic carbon content exhibited cytotoxic effects leading to apoptotic death in A549 cells. Exposure to PM10 aqueous extracts induced AVD and oxidative stress, which were correlated with cell viability inhibition and apoptotic cell shrinkage.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yongxin Yan, Shengjie Yao, Zhiqiang Jia, Junxia Zhao, Li'an Wang
Summary: Iso-suillin, a secondary metabolite isolated from Suillus flavus, has been shown to inhibit the proliferation of A549 human lung adenocarcinoma cells through inducing early G1 arrest and apoptosis in vitro. Phosphorylation of p53 at serines 15 and 20 may play a pivotal role in cell cycle arrest and apoptosis induced by iso-suillin. In vivo studies also demonstrated the anti-tumor effects of iso-suillin in inhibiting tumor growth and progression in an A549 xenograft model.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
Rayees Ahmad Bhat, Concetta Saoca, Cristina Cravana, Francesco Fazio, Maria Cristina Guerrera, Shyam Narayan Labh, Osman Sabri Kesbic
Summary: This research investigated the impact of heavy metals on the reproductive health of rainbow trout from two locations. The study found that fish from the more polluted site had higher levels of iron and zinc in their tissues. Additionally, these fish experienced more severe damage such as cellular damage, apoptosis, oxidative damage, and altered hormone levels, compared to fish from the less polluted site.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Yong Cai, Zhaoying Sheng, Jiying Wang
Summary: Xanthorrhizol, a sesquiterpenoid agent isolated from Curcuma xanthorrhiza, has shown anti-cancer properties by inducing oxidative stress, altering mitochondrial membrane potential, and modulating apoptotic signaling events in non-small cell lung carcinoma cells.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Chemistry, Physical
Hengming Zhang, Bing Zhou, Xia Zhou, Shu Yang, Shasha Liu, Xueyu Wang, Shideng Yuan, Shiling Yuan
Summary: The collision behavior of heavy oil droplets in a complex oil-in-water emulsion system under direct current and non-electric field coalescence was studied using molecular dynamics. The results showed that the blocking effect of Sodium dodecyl sulfate (SDS) molecules on the contact of oil components in emulsified oil droplets disappeared at a certain electric field intensity, leading to the aggregation of oil droplets facilitated by the accumulation of asphaltene and resin. SiO2 nanoparticles promoted the coalescence of oil droplets.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Microbiology
Maira Turiel-Silva, Camila Wendt, Edilene O. Silva, Ana Paula Drummond Rodrigues, Wanderley de Souza, Kildare Miranda, Jose A. P. Diniz
Summary: This study utilized electron microscopy and tomography to reconstruct the three-dimensional structure of C. lignieresi-infected red blood cells, revealing the remodeling of erythrocytes induced by the parasite and providing new insights into its parasitic mechanism.
JOURNAL OF EUKARYOTIC MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jarlene A. Lopes, Federica Collino, Clara Rodrigues-Ferreira, Luzia da Silva Sampaio, Gloria Costa-Sarmento, Camila H. C. Wendt, Fernando P. Almeida, Kildare R. Miranda, Tais H. Kasai-Brunswick, Rafael S. Lindoso, Adalberto Vieyra
Summary: This study investigated whether extracellular vesicles secreted by adipose tissue mesenchymal cells (EVs) can suppress the excessive production of mitochondrial O-2(center dot-) caused by acute kidney injury (AKI). The results showed that administration of EVs can decrease mitochondrial O-2(center dot-) formation and promote the recovery of renal structures and functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Edgleyson C. dos Santos, Leandro S. Silva, Alessandro S. Pinheiro, Douglas E. Teixeira, Diogo B. Peruchetti, Rodrigo P. Silva-Aguiar, Camila H. C. Wendt, Kildare R. Miranda, Andrelina N. Coelho-de-Souza, Jose Henrique Leal-Cardoso, Celso Caruso-Neves, Ana Acacia S. Pinheiro
Summary: This study demonstrates the potential anti-malarial effect of 1,8-cineole, which reduces parasitemia and has an impact on the erythrocytic cycle of the parasite.
Article
Biochemistry & Molecular Biology
Douglas Jardim-Messeder, Marcia Margis-Pinheiro, Gilberto Sachetto-Martins
Summary: The regulatory mechanisms of mitochondria in plant stress signaling are not fully understood. This study demonstrates that salicylic acid and adenine nucleotides regulate the activity of the succinate dehydrogenase complex and the production of reactive oxygen species in mitochondria. Salicylic acid induces the activity of the complex, while adenine nucleotides act through the SDH1 subunit. Adenine nucleotides regulate mitochondrial activity on the matrix side of the inner membrane, and ADP and ATP can limit mitochondrial oxygen consumption by inhibiting the cytochrome bc1 complex.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Article
Biochemistry & Molecular Biology
Douglas Jardim-Messeder, Marcel Zamocky, Gilberto Sachetto-Martins, Marcia Margis-Pinheiro
Summary: This article analyzes and discusses the origin, evolution, and function of the APX family. The study found that APX originated as a soluble enzyme and evolved to have targeting sequences for chloroplasts and mitochondria. Independent gene duplications and neofunctionalization events in certain angiosperm groups resulted in the development of APX isoforms localized in different subcellular compartments. The complexity of APX isoforms contributes to the adaptation of diverse plant species to changing environmental conditions.
Review
Microbiology
Veronica Jimenez, Kildare Miranda, Ingrid Augusto
Summary: Osmoregulation is a crucial cellular process for the survival of all organisms, and it holds even more significance for protists whose life cycles occur in various environments. This article summarizes the current understanding of the osmoregulatory mechanisms in the contractile vacuole and explores its newly discovered functions in cell trafficking and signaling.
JOURNAL OF EUKARYOTIC MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Juliana Maira Freitas Vieira, Laura Nicoleti Zamproni, Camila H. C. Wendt, Kildare Rocha de Miranda, Rafael Soares Lindoso, Sang Won Han
Summary: This study demonstrates that the therapeutic properties of mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) can be improved by enriching them with specific miRNAs through lentiviral vector modification. The overexpression of miR-210-5p in EVs significantly promotes tubular structure formation in human umbilical vein endothelial cells (HUVECs), leading to increased expression of angiogenic proteins and genes. This highlights the potential of manipulating EV cargo to enhance specific angiogenic potential.
Article
Physiology
Gustavo Monnerat, Tais Hanae Kasai-Brunswick, Karina Dutra Asensi, Danubia Silva dos Santos, Raiana Andrade Quintanilha Barbosa, Fernanda Cristina Paccola Mesquita, Joao Paulo Calvancanti Albuquerque, Pires Ferreira Raphaela, Camila Wendt, Kildare Miranda, Gilberto Barbosa Domont, Fabio Cesar Sousa Nogueira, Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho
Summary: This study modeled Hutchinson-Gilford Progeria Syndrome using cardiomyocytes derived from induced pluripotent stem cells and found significant changes in mitochondrial morphology and protein expression, suggesting novel mechanisms underlying premature cardiac aging.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mariana S. Rocha, Joao V. C. Batista, Michelle N. O. Melo, Vania E. B. de Campos, Anna Lecticia M. M. Toledo, Adriana P. Oliveira, Paulo H. S. Picciani, Stephan Baumgartner, Carla Holandino
Summary: This study investigated the physicochemical features of a hydrogel containing V. album dry extract and found that it exhibited nanometer-size micelles and improved thermal stability. In vitro assays demonstrated that the hydrogel selectively inhibited tumor cell growth, highlighting its potential as an herbal drug delivery system with antitumoral properties.
Article
Biology
Douglas Jardim-Messeder, Ygor de Souza-Vieira, Lucas Correa Lavaquial, Daniela Cassol, Vanessa Galhego, Gabriel Afonso Bastos, Thais Felix-Cordeiro, Regis Lopes Correa, Marcel Zamocky, Marcia Margis-Pinheiro, Gilberto Sachetto-Martins
Summary: Climate changes threaten agriculture and plants need to cope with different environmental conditions, including reactive oxygen species (ROS). The ascorbate-glutathione cycle, composed of APX, MDAR, DHAR, and GR enzymes, is the main antioxidant pathway in plants. This study identified and classified these genes in multiple plant species, predicted their subcellular localization, and contributed to understanding their evolutionary history. The expression pattern of these genes in response to drought stress in castor bean was also analyzed. Overall, this study provides important insights into the regulation of ROS metabolism in drought tolerance.
Article
Multidisciplinary Sciences
Wendell Girard-Dias, Ingrid Augusto, Tacio V. A. Fernandes, Pedro G. Pascutti, Wanderley de Souza, Kildare Miranda
Summary: In this study, the three-dimensional distribution of diffusible elements within acidocalcisomes in Trypanosoma cruzi was mapped using advanced electron microscopy techniques. The existence of nanodomains with specific element distribution patterns was discovered. These findings have significant implications for understanding nanophysiology of organelles.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Plant Sciences
Michelle Nonato de Oliveira Melo, Joao Vitor da Costa Batista, Evelyn Maribel Condori Penaloza, Adriana Passos Oliveira, Rafael Garrett, Stephan Baumgartner, Carla Holandino
Summary: This article summarizes the research on alcoholic extracts of Viscum species, revealing their hypotensive, anticancer, antimicrobial, analgesic, and anti-inflammatory activities. Flavonoids, phenolic acids, and terpenoids are identified as the main components. However, there is a lack of clinical studies on these extracts.
Article
Multidisciplinary Sciences
Anna L. S. Barreto, Ariadne N. Alonso, Daniel C. De Moraes, Jose A. R. Curvelo, Kildare Miranda, Maristela B. Portela, Antonio Ferreira-Pereira, Thais Souto-Padron, Rosangela Maria De A. Soares
Summary: The search for new therapeutic strategies for leishmaniasis treatment is essential. The aqueous extract of the marine sponge Dercitus (Stoeba) latex displayed antileishmanial activity and moderate toxicity against peritonial macrophages. This study suggests that Dercitus (Stoeba) latex may be a potential source of drugs for the treatment of L. amazonensis infections.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Cell & Tissue Engineering
Clara Rodrigues-Ferreira, Jarlene Alecia Lopes, Priscila Fonseca Carneiro, Cristiane dos Santos Lessa, Antonio Galina, Adalberto Vieyra
Summary: Acute kidney injury due to ischemia followed by reperfusion (IR) is a severe condition that affects the proximal tubule cells' mitochondrial function and calcium handling mechanism. However, administration of bone marrow mononuclear cells (BMMC) can protect against these alterations and provide defense mechanism against IR injury by stabilizing the adenine nucleotide translocase (ANT) and preventing the opening of the permeability transition pore (PTP).
CELL TRANSPLANTATION
(2022)
Article
Nanoscience & Nanotechnology
Jhon Jhamilton Artunduaga Bonilla, Leandro Honorato, Allan J. Guimaraes, Kildare Miranda, Leonardo Nimrichter
Summary: This research focuses on the green synthesis of chitosan-functionalized silver nanoparticles (AgNPs@Chi) and their potential applications in combating sporotrichosis. The results demonstrate that AgNPs@Chi exhibit low toxicity, inhibitory effects on fungal growth, and stimulating effects on cell growth and tissue repair. These nanocomposites have the potential to be a non-toxic and efficient alternative for sporotrichosis treatment.
FRONTIERS IN NANOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Priyanga Kumar, Noel Nesakumar, Jayashree Gopal, Sakthivel Sivasubramanian, Srinivasan Vedantham, John Bosco Balaguru Rayappan
Summary: This study developed an electrochemical biosensor for measuring MG levels in the plasma of type-2 diabetes mellitus patients. The biosensor showed a wide linear concentration range, high sensitivity, and a 90% correlation with ELISA data. It also exhibited a significant correlation with HbA1c and fasting plasma glucose levels.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Cristina Tortolini, Valeria Gigli, Antonio Angeloni, Federico Tasca, Nguyen T. K. Thanh, Riccarda Antiochia
Summary: The development of a novel voltammetric immunosensor for the detection of salivary MMP-8 at the point-of-care is described. The sensor showed good performance and comparable results to the conventional ELISA method when tested in real saliva samples. This biosensor is single-use, cost-effective, and requires a small quantity of test medium and a short preparation time.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Rimsha B. Jamal, Ulrich Bay Gosewinkel, Elena E. Ferapontova
Summary: Pathogen-triggered infections are a severe global threat to human health. Researchers have developed a fast and inexpensive electrocatalytic aptamer assay for the specific and ultrasensitive detection of E. coli, allowing for timely treatment and prevention. The method is fast, sensitive, and can be used in field and point-of-care applications for analysis of bacteria in the human environment.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Miao Liu, Yuwei Wang, Shanshan Tang, Wei Wang, Axin Liang, Aiqin Luo
Summary: An unlabeled ratiometric molecular imprinted electrochemiluminescence sensor was developed for the determination of trace uric acid using MXene@NaAsc, CdSe@ZnS quantum dots, and molecularly imprinted polymer composites modified glass carbon electrode. This sensor, with easy preparation, great selectivity, and excellent sensitivity, successfully detected uric acid in human serum.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Charlotte Da Silva, Camille Lamarche, Carole Pichereaux, Emmanuelle Mouton-Barbosa, Gauthier Demol, Sebastien Boisne, Etienne Dague, Odile Burlet-Schiltz, Flavien Pillet, Marie-Pierre Rols
Summary: Low-energy electron beams (LEEB) are a safe and practical sterilization solution for industrial applications. To address the limitations of LEEB, we developed a low-energy pulsed electron beam generator (LEPEB) that can effectively and efficiently eradicate bacteria in a wide range of industrial applications.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Daniel Dobrovodsky, Ales Danhel, Daniel Renciuk, Jean-Louis Mergny, Miroslav Fojta
Summary: In this study, N-methyl mesoporphyrin IX (NMM) was utilized as a voltammetric probe for the electrochemical detection of G4s. The detection of NMM was achieved by cyclic voltammetry on a hanging mercury drop electrode (HMDE) with a limit of detection (LOD) of 40 nM. The reduction signal of NMM was found to be significantly higher when G4 oligodeoxynucleotides (G4 ODNs) were present compared to single- or double-stranded ODNs or unfolded ODNs capable of forming G4s. Gradual transition from unstructured single strand to G4, induced by increasing concentrations of the G4 stabilizing K+ ions, was detected for the first time using electrochemical methods. Circular dichroism spectroscopy provided support for the obtained results. This work expands on the utilization of electrochemical probes for DNA secondary structure recognition and offers a proof of principle for the development of novel electroanalytical methods for nucleic acid structure studies.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Mengjiao Zhu, Yu Liu, Meiyue Wang, Tao Liu, Zhenyu Chu, Wanqin Jin
Summary: Early rapid diagnosis of COVID-19 is crucial for reducing the risk of severe symptoms and loss of lung function. Researchers have proposed an ultrafast and ultrasensitive DNA sensor that can accurately detect the virus in a short period of time, with outstanding selectivity.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fatima-Zahra Ait-Itto, James A. Behan, Mathieu Martinez, Frederic Barriere
Summary: This study investigated the feasibility of using ancient marine sediments as inoculum for bioanode development in microbial fuel cells (MFC). The results showed the presence of two exoelectrogenic bacterial genera in these iron-rich sediments and confirmed that the development of the bioanode derived from the native microbiota. This study has important implications for understanding the role of these bacteria in broader paleoenvironmental phenomena.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Issa Fall, Bastien Doumeche, Sofiene Abdellaoui, Caroline Remond, Harivony Rakotoarivonina, Marjorie Ochs
Summary: This article presents a novel electrochemical tool based on lignin-coated paper electrodes for the detection and characterization of ligninolytic activity. The suitability of this method has been demonstrated using a catalaseperoxidase isolated from Thermobacillus xylanilyticus.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Chenyi Zhuo, Dehong Yu, Jiuying Cui, Zichun Song, Qianli Tang, Xianjiu Liao, Zhao Liu, Ning Xin, Lu Lou, Fenglei Gao
Summary: A label-free detection strategy for quantification of Apolipoprotein A4 (Apo-A4) has been developed based on rolling circle amplification (RCA) and proximity hybridization-induced DNAzyme-driven bipedal DNA walker. This method shows high sensitivity and selectivity for a wide range of protein targets.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Niloufar Fattahi, Jeffrey Reed, Evan Heronemus, Priyasha Fernando, Ryan Hansen, Prathap Parameswaran
Summary: In this study, polyethylene glycol hydrogels were developed as protective coatings for electroactive biofilms, improving their viability under low resource conditions and ammonia-N shocks.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiaopeng Hou, Qiongyi Cheng, Hui Wang
Summary: A self-cleaning paper-based microfluidic biosensor was developed using hydrophobic paper decorated with polymeric octadecyl trichlorosilane. The biosensor showed improved performance and could effectively measure the concentration of copper ions in livestock feed and manure.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yanling Zhang, Jie Wang, Min Liu, Yun Ni, Yao Yue, Dawei He, Ruijiang Liu
Summary: An innovative electrochemical biosensor has been developed for sensitive detection of HER2 protein, an important tumor marker for breast cancer diagnosis and treatment evaluation. The biosensor utilizes specific recognition probes and nanomaterials, along with a unique sensing strategy, to achieve ultra-low detection limit and demonstrate excellent selectivity, reproducibility, and stability.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Humayun Amir, Vasanth Subramanian, Sundaram Sornambikai, Nagamony Ponpandian, Chinnusamy Viswanathan
Summary: In this study, the electrochemical detection of breast cancer biomarker HER2 was successfully achieved using the N-CQDs/GS as the detector. The BSA-modified HER2 Antibody/N-CQDs/GS immunoelectrode preserved excellent activity for the biosensor, while the GS electrode provided high stability and conductivity. The method exhibited a low detection limit and optimal specificity, stability, and reproducibility for detecting HER-2 protein in untreated blood samples from breast cancer patients.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ilona Uzieliene, Anton Popov, Raminta Vaiciuleviciute, Gailute Kirdaite, Eiva Bernotiene, Almira Ramanaviciene
Summary: This review discusses the application of polypyrrole (Ppy), an electroconductive polymer, in cell culture experiments with electrical stimulation (ES) and its potential for tissue regeneration. Ppy can direct ES to cells and stimulate differentiation towards different cell lineages. Different types of Ppy materials and their combination with active molecules are explored.
BIOELECTROCHEMISTRY
(2024)
