Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE‐TPA): A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Study
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE‐TPA): A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Study
Authors
Keywords
-
Journal
ANNALS OF NEUROLOGY
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2019-11-13
DOI
10.1002/ana.25644
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- tPA Helpers in the Treatment of Acute Ischemic Stroke: Are They Ready for Clinical Use?
- (2019) Jong S. Kim Journal of Stroke
- Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
- (2018) Konark Malhotra et al. JOURNAL OF NEUROLOGY
- MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset
- (2018) Götz Thomalla et al. NEW ENGLAND JOURNAL OF MEDICINE
- Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging
- (2018) Gregory W. Albers et al. NEW ENGLAND JOURNAL OF MEDICINE
- Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
- (2018) Raul G. Nogueira et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting Reperfusion Injury in the Age of Mechanical Thrombectomy
- (2018) Atsushi Mizuma et al. STROKE
- Neuroprotectants in the Era of Reperfusion Therapy
- (2018) Ángel Chamorro Journal of Stroke
- Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow
- (2018) De-Cai Tian et al. ANNALS OF NEUROLOGY
- Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activ
- (2018) Patrick Lyden et al. ANNALS OF NEUROLOGY
- Therapeutic Strategies to Attenuate Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment for Acute Ischemic Stroke
- (2017) Masato Kanazawa et al. Journal of Atherosclerosis and Thrombosis
- Strategies to Extend Thrombolytic Time Window for Ischemic Stroke Treatment: An Unmet Clinical Need
- (2017) Ike dela Peña et al. Journal of Stroke
- Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials
- (2016) Mayank Goyal et al. LANCET
- Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation
- (2016) Ángel Chamorro et al. LANCET NEUROLOGY
- Extending the Time Window for Endovascular and Pharmacological Reperfusion
- (2016) Nils Henninger et al. Translational Stroke Research
- Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic StrokeCLINICAL PERSPECTIVE
- (2015) Zilong Zhu et al. CIRCULATION
- Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
- (2015) Justyna Pielecka-Fortuna et al. eLife
- Matrix Metalloproteinase-9: Dual Role and Temporal Profile in Intracerebral Hemorrhage
- (2014) Jason J. Chang et al. Journal of Stroke & Cerebrovascular Diseases
- Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials
- (2014) Jonathan Emberson et al. LANCET
- Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial
- (2014) Ángel Chamorro et al. LANCET NEUROLOGY
- Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective
- (2014) Péter Bencsik et al. PHARMACOLOGICAL RESEARCH
- Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischaemic stroke
- (2014) Sébastien Lenglet et al. THROMBOSIS AND HAEMOSTASIS
- Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans
- (2013) Glen C Jickling et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- The iScore Predicts Effectiveness of Thrombolytic Therapy for Acute Ischemic Stroke
- (2012) Gustavo Saposnik et al. STROKE
- Seven-Day NIHSS Is a Sensitive Outcome Measure for Exploratory Clinical Trials in Acute Stroke
- (2012) Daniel M. Kerr et al. STROKE
- SP-8203 shows neuroprotective effects and improves cognitive impairment in ischemic brain injury through NMDA receptor
- (2011) Su-Jin Noh et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- SP-8203 reduces oxidative stress via SOD activity and behavioral deficit in cerebral ischemia
- (2010) Su-Jin Noh et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- A new penumbra: transitioning from injury into repair after stroke
- (2008) Eng H Lo NATURE MEDICINE
- Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
- (2008) Werner Hacke et al. NEW ENGLAND JOURNAL OF MEDICINE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now