Article
Materials Science, Multidisciplinary
Yu-Fon Chen, Yao-Tsung Yeh, Yu-Chu Su, Chorng-An Liao, Cheng-Hsieh Huang, Ying-Jung Cheng, Jeng-Shiung Jan
Summary: This study investigated the anticancer activity of a cell adhesion inhibiting peptide comprised of L-lysine (Lys) and Benzyl-L-cysteine (BnCys) and its impact on intestinal microbiota. The peptide inhibits cell migration and adhesion by interfering with E-cadherin packaging and disrupting cell membrane integrity, leading to apoptotic pathways activation. Furthermore, the peptide when combined with low-dose cisplatin effectively inhibits tumor growth and metastasis without causing weight loss, and it increases the relative proportion of intestinal Akkermansia muciniphila (Akk). These findings suggest promising potential for designing cell migration/adhesion inhibiting peptides that target membrane E-cadherin for anticancer therapy.
MATERIALS & DESIGN
(2022)
Article
Pharmacology & Pharmacy
Aleen Khoury, Jennette A. Sakoff, Jayne Gilbert, Kieran F. Scott, Shawan Karan, Christopher P. Gordon, Janice R. Aldrich-Wright
Summary: Platinum(IV) prodrugs showed outstanding activity against various cancer cell lines, with nanomolar activities observed. Cellular accumulation of the complexes was correlated with increased cytotoxicity. COX inhibition or lipophilicity did not solely determine the cytotoxicity of these prodrugs.
Review
Chemistry, Inorganic & Nuclear
Zoufeng Xu, Zhigang Wang, Zhiqin Deng, Guangyu Zhu
Summary: Platinum-based anticancer drugs have been widely used in clinical practice for over 40 years, with a focus on developing platinum(IV) prodrugs based on traditional platinum(II) anticancer drugs. Recent progress in the field includes synthesizing platinum(IV) prodrugs with new oxidizing reagents, understanding the hydrolysis and stability of platinum(IV) complexes, and exploring reduction processes to achieve controllable intracellular reduction of platinum(IV) prodrugs. This review aims to enhance researchers' understanding of platinum(IV) anticancer prodrugs and inspire new strategies, ideas, and applications in metal-based drugs.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Seong-Bin Yang, Nipa Banik, Bomin Han, Dong-Nyeong Lee, Jooho Park
Summary: With advancements in bioinformatics, amino acid-based drug-design strategies have become increasingly important in pharmaceutics. Despite previous limitations of low selectivity and rapid degradation, peptide-based therapeutics combined with drug-delivery systems have emerged, particularly in anticancer therapy.
Article
Engineering, Biomedical
Wei Jiang, Zuoxiu Tie, Chi Yu, Yu Chen, Dan Liu, Bin Li
Summary: This study constructs a glutathione (GSH)-responsive nanoplatform to inhibit the energy metabolism and lysosomal activity of tumor cells, making tumor cells remain sensitive to cisplatin. By inhibiting the energy metabolism and autophagy-lysosome pathway of tumor cells, the nanoplatform prevents tumor cells from entering a low-energy dormancy state and enhances the chemotherapeutic effect of cisplatin.
Article
Chemistry, Multidisciplinary
Tiantian Guo, Haiping Zhong, Xingwei Li, Jingqing Mu, Tao Liu, Na Yu, Yang Zhao, Xing-Jie Liang, Shutao Guo
Summary: In this study, we synthesized four dextran-paclitaxel (PTX) conjugates with different drug contents and used them to construct self-assembled nanoparticles. We investigated how PTX content influenced the performance and antitumor efficacy of the nanoparticles. The results showed that nanoparticles with lower PTX content exhibited faster drug release, increased tumor accumulation, and enhanced antitumor efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Medicinal
Anne-Laure Villard, Anne-Marie Aubertin, Suzanne Peyrottes, Christian Perigaud
Summary: A novel series of phosphoramidate pronucleotides with remarkable anti-HIV activity and efficient intracellular combination release have been reported. These prodrugs exhibit higher selectivity index than the constitutive nucleoside analogues, opening up new possibilities for further drug combination studies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Nanxin Liu, Qinhua Chen, Qingqing Zhang, Jin Wang, Ru Si, Jie Zhang, Xiaoyan Pan
Summary: Cancer is the second leading cause of human death, and cytotoxic agents are the most commonly used drugs in clinics, despite their inherent disadvantages such as toxicity, low selectivity, and poor solubility. To overcome these drawbacks, various drug delivery strategies based on prodrugs have been developed, which can optimize the ADME properties of cytotoxic agents and improve their selectivity at the target site, thereby greatly enhancing the anticancer effect. This review systematically summarized the studies of prodrug-based drug delivery systems over the past five to ten years, focusing on solubility, controlled release, in situ concentration, and targeting.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Qiyuan Zhou, Shu Chen, Zoufeng Xu, Gongyuan Liu, Shuyuan Zhang, Zhigang Wang, Man-Kit Tse, Shek-Man Yiu, Guangyu Zhu
Summary: This study reports the synthesis of Pt-IV complexes bearing axial pyridines through ligand exchange reactions. It was discovered that these axial pyridines can be quickly released after reduction, indicating their potential as axial leaving groups. Two multitargeted Pt-IV prodrugs containing bioactive pyridinyl ligands, a PARP inhibitor and an EGFR tyrosine kinase inhibitor, were successfully obtained using this method. These conjugates show great potential for overcoming drug resistance, with the latter inhibiting the growth of Pt-resistant tumor in vivo. This research expands the synthetic methods for Pt-IV prodrugs and increases the range of bioactive axial ligands that can be conjugated to a Pt-IV center.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Pharmacology & Pharmacy
Hanhee Cho, Seong Ik Jeon, Cheol-Hee Ahn, Man Kyu Shim, Kwangmeyung Kim
Summary: Albumin has the potential to improve the delivery of anticancer drugs by acting as a natural carrier. It can enhance the circulation time of the drugs and passively target tumors through enhanced permeability and retention. However, the delivery efficiency of exogenous albumin formulations is low, which increases the risk of systemic toxicity. Prodrugs that bind endogenous albumin have been investigated as a safer and more effective drug delivery option.
Article
Chemistry, Multidisciplinary
Alexandre Bordat, Tanguy Boissenot, Nada Ibrahim, Marianne Ferrere, Manon Leveque, Lea Potiron, Stephanie Denis, Sebastien Garcia-Argote, Olivia Carvalho, Jerome Abadie, Catherine Cailleau, Gregory Pieters, Nicolas Tsapis, Julien Nicolas
Summary: Chemotherapy is commonly administered via the intravenous route, but has limitations. Researchers have developed a new method for subcutaneous administration of anticancer drugs through the design of hydrophilic polymer prodrugs, which successfully avoids local toxicity and outperforms commercial formulations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Marta Szumilak, Anna Wiktorowska-Owczarek, Andrzej Stanczak
Summary: Hybrid drugs targeting multiple points of cancer cells have been extensively explored in recent years. They possess simpler pharmacokinetic profiles, reduce the possibility of drug interactions, and facilitate the drug development process.
Article
Medicine, Research & Experimental
Tushar Date, Kaushik Kuche, Rohan Ghadi, Pradeep Kumar, Sanyog Jain
Summary: Cisplatin is an anticancer drug with challenges in drug delivery. Cisplatin(IV) prodrug formation can effectively resolve these challenges. The selection of axial ligands plays a key role in determining the therapeutic outcomes. Rational design of cisplatin(IV) derivatives can improve their stability and cellular uptake, reducing side effects and offering potential in resolving cisplatin drug delivery challenges.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Elena Giusto, Ludmila Zarska, Darren Fergal Beirne, Arianna Rossi, Giada Bassi, Andrea Ruffini, Monica Montesi, Diego Montagner, Vaclav Ranc, Silvia Panseri
Summary: This study developed a graphene oxide-based nanocarrier to overcome the limitations of platinum-based chemotherapeutics. The results demonstrated that this nanoplatform has good anti-tumor effects in various cancer cells and potential for inhibiting cell migration.
Article
Engineering, Biomedical
Eunkyeong Jung, Seung Won Jeong, Yeongjong Lee, Chanhee Jeon, Hyunbin Shin, Nanhee Song, Yujin Lee, Dongwon Lee
Summary: Stimulus-responsive self-assembling prodrug-based nanomedicine has emerged as a novel paradigm in controlled drug delivery, showing potential in cancer treatment by releasing multiple active substances and exerting cooperative anticancer effects.
Article
Multidisciplinary Sciences
Ahmad Amirshaghaghi, Lesan Yan, Joann Miller, Yonathan Daniel, Joel M. Stein, Theresa M. Busch, Zhiliang Cheng, Andrew Tsourkas
SCIENTIFIC REPORTS
(2019)
Review
Engineering, Biomedical
Qingzheng Zhang, Bo Shi, Jianxun Ding, Lesan Yan, Jayesh P. Thawani, Changfeng Fu, Xuesi Chen
ACTA BIOMATERIALIA
(2019)
Article
Biochemical Research Methods
Lesan Yan, Lijun Luo, Ahmad Arnirshaghaghi, Joann Miller, Cathy Meng, Tianyan You, Theresa M. Busch, Andrew Tsourkas, Zhiliang Cheng
BIOCONJUGATE CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Jessica F. Liu, Ziyang Lan, Carolina Ferrari, Joel M. Stein, Elizabeth Higbee-Dempsey, Lesan Yan, Ahmad Amirshaghaghi, Zhiliang Cheng, David Issadore, Andrew Tsourkas
Article
Chemistry, Multidisciplinary
Sonia Kartha, Lesan Yan, Meagan E. Ita, Ahmad Amirshaghaghi, Lijun Luo, Yulong Wei, Andrew Tsourkas, Beth A. Winkelstein, Zhiliang Cheng
Article
Engineering, Biomedical
Xianzhen Dong, Ping Wu, Lesan Yan, Kun Liu, Wenying Wei, Qiang Cheng, Xinyue Liang, Yun Chen, Honglian Dai
Summary: This study explores the effect of an oriented nanofiber/Deferoxamine (DFO) scaffold in the construction of a favorable regenerative microenvironment for nerve regeneration. In vitro experiments showed that the scaffold sustained release of DFO, promoting the migration and tube formation of endothelial cells and the expression of angiogenesis-related genes. The physical cues provided by the nanofibers regulated macrophage polarization and reduced the expression of inflammatory factors. In vivo results demonstrated reduced inflammation and enhanced nerve regeneration with the use of the oriented nanofibrous scaffold and in-situ release of DFO.
Review
Chemistry, Multidisciplinary
Kai Liu, Lesan Yan, Ruotao Li, Zhiming Song, Jianxun Ding, Bin Liu, Xuesi Chen
Summary: Nerve autograft is currently the preferred treatment for peripheral nerve defects but has limitations. Emerging nerve guide conduits (NGCs), especially those made through 3D printing, offer effective platforms for repairing peripheral nerve defects.
Article
Multidisciplinary Sciences
Fabiana Zappala, Elizabeth Higbee-Dempsey, Bian Jang, Joann Miller, Lesan Yan, Nicholas G. Minutolo, Gabriela T. Rosado Gonzalez, Andrew Tsourkas, Burcin Altun Ozdemir
Summary: Researchers have developed a simple method to attach a T cell-redirecting domain to off-the-shelf human immunoglobulin G (IgG) or native IgG, allowing the generation of T cell-redirecting autoantibodies (TRAAbs) without the need for antibody engineering, cloning, or knowledge of the antibody sequence. These TRAAbs preferentially bind tumor tissue over healthy tissue, indicating a previously unexplored therapeutic window. This approach represents a new paradigm in personalized medicine.
Article
Biochemistry & Molecular Biology
Hanning Zhang, Shuangyu Tian, Mu Li, Jinhai Xie, HongLian Dai, Liuyong Hu, Lesan Yan
Summary: A novel donor-acceptor conjugated polymer PDPPDTP was designed and synthesized, showing strong absorption in the near-infrared range and excellent photothermal performance. Encapsulated into nanomicelles by the microemulsion method, the spherical micelles exhibited good stability and high encapsulation efficiency of the conjugated polymer.
Article
Biochemistry & Molecular Biology
Jinhai Xie, Shuangyu Tian, Hanning Zhang, Congshu Feng, Yingchao Han, Honglian Dai, Lesan Yan
Summary: Designing nano-drug delivery vehicles that respond to stimuli from the tumor microenvironment is crucial in cancer therapy. Enzyme-responsive nano-drug delivery systems are particularly effective as they target tumor-specific and highly expressed enzymes, resulting in increased drug release at the target sites and reduced toxicity to normal tissues. NQO1, an important reductase associated with cancer, is overexpressed in certain cancer cells, making the design of nanocarriers with high selectivity and responsiveness to NQO1 significant for tumor diagnosis and treatment.
Article
Engineering, Biomedical
Xiaohan Jiang, Qiang Yang, Ruogu Qi, Lesan Yan
Summary: Drug resistance and cancer metastasis pose significant challenges to platinum-based chemotherapy. This study developed a practical method to create satraplatin-loaded nanoparticles (SatPt-NPs) using D-α-tocopheryl polyethylene glycol succinate (TPGS)-based polymers. The experimental results showed that SatPt-NPs had comparable efficacy to A2780 in treating the cisplatin-resistant ovarian cancer cell line (A2780DDP), indicating their potential in overcoming drug resistance. Additionally, SatPt-NPs were able to evade glutathione (GSH) detoxification, which further enhanced their performance against drug resistance. Overall, SatPt-NPs hold tremendous potential in cancer treatment.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Materials Science, Biomaterials
Diya Shi, Congshu Feng, Jinhai Xie, Xi Zhang, HongLian Dai, Lesan Yan
Summary: This paper systematically reviews recent studies on nanomedicines targeting overexpressed sPLA2 in various diseases, exploring the therapeutic mechanism and potential applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Meeting Abstract
Orthopedics
T. Gui, Y. Wei, L. Luo, F. Yu, L. Yan, L. Yao, L. Zhong, W. Yu, B. Han, J. Patel, F. Beier, Z. Shao, L. Han, R. Mauck, A. Tsourkas, J. Ahn, Z. Cheng, L. Qin
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Nanoscience & Nanotechnology
Lijun Luo, Lesan Yan, Ahmad Amirshaghaghi, Yulong Wei, Tianyan You, Sunil Singhal, Andrew Tsourkas, Zhiliang Cheng
ACS APPLIED BIO MATERIALS
(2020)
Article
Materials Science, Biomaterials
Yanpiao Long, Lesan Yan, Honglian Dai, Dong Yang, Xiaopei Wu, Xianzhen Dong, Kun Liu, Wenying Wei, Yuzhe Chen
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
